B Cell News and Research

RSS

Lilly and Transition Therapeutics announce licensing and collaboration agreement

Eli Lilly and Company and Transition Therapeutics Inc. has announced that the two companies have entered into a licensing and collaboration agreement granting Lilly exclusive worldwide rights to develop and commercialize Transition's gastrin based therapies, including the lead compound TT-223, which is currently in early Phase II testing.

14 Mar 2008

Cause of prolonged penile erection

Priapism (prolonged penile erection in the absence of sexual interest) is common in male individuals with sickle cell disease (SCD), a blood disorder characterized by abnormally shaped red blood cells.

14 Mar 2008

Damaged veins heal faster with heparin treatment, laboratory study finds

A commonly used medication that prevents blood clots from forming may also prevent existing clots from damaging delicate vein walls and may accelerate healing in a clot-damaged area of vein wall, according to new research from the University of Michigan Cardiovascular Center.

14 Mar 2008

Heavier alcohol consumption increases the risk of esophageal squamous cell carcinoma

Heavier alcohol consumption increases the risk of esophageal squamous cell carcinoma (ESCC). There are synergetic interactions among alcohol drinking and ALDH2, ADH1B, CYP2E1 genotypes.

14 Mar 2008

TRPV1 receptor blockers may interfere with brain functions

A new class of painkillers that block a receptor called TRPV1 may interfere with brain functions such as learning and memory, a new study suggests.

13 Mar 2008

Study helps explain how tumor cells rapidly grow and proliferate

Nearly 80 years ago, scientist Otto Warburg observed that cancer cells perform energy metabolism in a way that is different from normal adult cells.

13 Mar 2008

Researchers find cause of severe allergic reaction to cetuximab

Clinicians have been perplexed by the fact that some patients given the drug cetuximab - an immune-based therapy commonly used to treat persons diagnosed with head and neck cancer, or colon cancer - have a severe and rapid adverse reaction to the drug.

13 Mar 2008

Research could put penicillin back in battle against antibiotic resistant bugs

Research led by the University of Warwick has uncovered exactly how the bacterium Streptococcus pneumoniae has become resistant to the antibiotic penicillin.

13 Mar 2008

Obesity bottlenecks cellular power plant

The machinery responsible for energy production in fat cells is working poorly as a result of obesity.

13 Mar 2008

Discovery could lead to much-needed kidney failure treatment

The unwanted activation of an important cell-signaling pathway may play a role in two kidney problems that are major causes of end-stage renal disease, scientists at the Albert Einstein College of Medicine of Yeshiva University have found.

13 Mar 2008

Good news for people with glycogen storage disease type Ia

A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans, according to Duke University Medical Center researchers.

13 Mar 2008

AstraZeneca completes enrollment in phase III studies of cancer drug vandetanib

AstraZeneca has announced that it has completed patient enrollment in two pivotal Phase III studies for vandetanib, the company's investigational, once-daily oral anti-cancer drug, for the second-line treatment of non-small cell lung cancer (NSCLC).

13 Mar 2008

Researchers model emotional impact of cocaine in rats

Cocaine addicts often suffer a downward emotional spiral that is a key to their craving and chronic relapse.

13 Mar 2008

DNA detectives find genetic markers for lung cancers most likely to recur

Researchers at the Johns Hopkins Kimmel Cancer Center have uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early-stage lung cancers that look like good predictors of which of these cancers are more likely to recur.

13 Mar 2008

Caspase-12: MUHC researcher finds new defense mechanism against intestinal inflammation

The body's first line of defence against pathogenic bacteria that we ingest may not be the immune system but rather the cells that line the intestine.

13 Mar 2008

Nuclear protein SATB1 triggers aggressive breast cancer

SATB1 is a nuclear protein well known for its crucial role in regulating gene expression during the differentiation and activation of T cells, making it a key player in the immune system.

13 Mar 2008

Researchers may have found test for depression

Researchers from the University of Illinois at Chicago College of Medicine have discovered that a change in the location of a protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression and to determine whether a particular antidepressant therapy will provide a successful response.

12 Mar 2008