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New research reveals how gut bacteria and lipid metabolism may affect AD, other brain diseases

BIOCRATES Life Sciences AG, a global leader in targeted metabolomics, reported today the Alzheimer’s Disease Metabolomics Consortium’s new breakthrough in Alzheimer’s research, which connects the Gut-Liver-Brain axis in the development and progression of Alzheimer’s disease (AD). During the Alzheimer’s Association International Conference, Chicago, USA, researchers reported new data on how gut bacteria and lipid metabolism may influence AD.

26 Jul 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

New research supports need for a radical cure strategy to tackle debilitating form of malaria

A team of malaria experts from a large international research collaboration has published results supporting the need for a radical cure strategy to tackle one of the most debilitating forms of malaria caused by the Plasmodium vivax parasite.

26 Jul 2018

Cancer and heart disease are deadlier in the developing world than in western nations

Diseases such as cancer, heart disease and stroke are deadlier in the developing world than in rich nations. This is the finding of a new analysis from researchers at Imperial College London.

26 Jul 2018

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

Omeros Corporation announced today that the European Medicines Agency's Committee for Orphan Medicinal Products issued a positive opinion recommending orphan drug designation of OMS721 for treatment in hematopoietic stem cell transplantation.

25 Jul 2018

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Merck, known as MSD outside the United States and Canada, announced today that the pivotal Phase 3 KEYNOTE-048 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma, met a primary endpoint of overall survival as monotherapy in patients whose tumors expressed PD-L1.

25 Jul 2018

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Reduced levels of plasmalogens - a class of lipids created in the liver that are integral to cell membranes in the brain - are associated with an increased risk of Alzheimer's Disease, according to new research presented this week at the Alzheimer's Association International Conference 2018 by Mitchel A. Kling, MD, an associate professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania and the Veterans Affairs Medical Center.

25 Jul 2018

Depleting microbiome with antibiotics can have metabolic effects in mice

A new study from the Salk Institute has found that mice that have their microbiomes depleted with antibiotics have decreased levels of glucose in their blood and better insulin sensitivity.

24 Jul 2018

HCV testing can be successfully implemented in emergency department setting

Boston Medical Center has shown that testing for the Hepatitis C Viru outside the typical high-risk population can be successfully implemented in an emergency department setting, resulting in more patients being screened, diagnosed and treated who might not have been otherwise.

23 Jul 2018

FDA approves first drug for treatment of adult AML patients with specific genetic mutation

The U.S. Food and Drug Administration today approved Tibsovo (ivosidenib) tablets for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation.

20 Jul 2018

AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia

AbbVie, a research-based global biopharmaceutical company, today announced it submitted a supplemental New Drug Application to the U.S. Food and Drug Administration for venetoclax in combination with a hypomethylating agent or in combination with low-dose cytarabine for the treatment of newly diagnosed patients with acute myeloid leukemia who are ineligible for intensive chemotherapy.

20 Jul 2018

Protective qualities of 'good cholesterol' reduce after menopause

Levels of high density lipoprotein (HDL) may not accurately represent cardiovascular risk in older women, according to a new study.

19 Jul 2018

Analysis reveals disparities in cancer death rates among minority groups

Analysis of cancer death data from 2008-2014 in New York state revealed high cancer mortality rates among U.S.-born blacks and Puerto Ricans and relatively low cancer mortality rates among Hispanic South Americans and Asians.

19 Jul 2018

Study finds link between DNA methylation and non-alcoholic fatty liver disease

DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But sometimes this process goes awry.

19 Jul 2018

Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments

Scientists at Dana-Farber/Brigham and Women's Cancer Center have identified biomarkers in melanoma that could help tailor immunotherapy treatments to maximize the benefits for patients while reducing the likelihood of severe side effects.

19 Jul 2018

Alcohol-related cirrhosis mortality on the rise among young adults

Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.

19 Jul 2018

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

The U.S. Food and Drug Administration today approved Kisqali (ribociclib) in combination with an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy.

19 Jul 2018

Study calls for new gold standard in research to treat non-alcoholic steatohepatitis

A new study by scientists from the Vrije Universiteit Brussel calls for a new gold standard in research to treat non-alcoholic steatohepatitis, an obesity-linked chronic liver disease impacting millions of people of all ages worldwide, which can progress to liver cancer if untreated, creating a massive strain on an already overburdened healthcare system.

18 Jul 2018

Health burdens of very high risk drinking are potentially large, study reveals

In an Addiction Biology study, the estimated prevalence of very high risk drinking level (VHRDL, defined as drinking >100 g of ethanol per day) in 13 European Union countries was 0.74-0.85 percent, with a risk of disease or injury of 13.5 per 100 people with VHRDL per year.

18 Jul 2018

Single genetic change in gut bacteria can lead to obesity

A new study has shown that a single genetic change in a bacterium of the gut microbiome can lead to metabolic diseases such as obesity.

18 Jul 2018

Liver News and Research

New research reveals how gut bacteria and lipid metabolism may affect AD, other brain diseases

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

New research supports need for a radical cure strategy to tackle debilitating form of malaria

Cancer and heart disease are deadlier in the developing world than in western nations

Omeros’ OMS721 receives positive opinion from EMA's COMP for treating hematopoietic stem cell transplant

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Depleting microbiome with antibiotics can have metabolic effects in mice

HCV testing can be successfully implemented in emergency department setting

FDA approves first drug for treatment of adult AML patients with specific genetic mutation

AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia

Protective qualities of 'good cholesterol' reduce after menopause

Analysis reveals disparities in cancer death rates among minority groups

Study finds link between DNA methylation and non-alcoholic fatty liver disease

Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments

Alcohol-related cirrhosis mortality on the rise among young adults

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

Study calls for new gold standard in research to treat non-alcoholic steatohepatitis

Health burdens of very high risk drinking are potentially large, study reveals

Single genetic change in gut bacteria can lead to obesity

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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