Animal Model News and Research

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SARS-CoV-2 leaves long-term impact on olfactory neurocircuit

The current study looked at the impact of the virus on the CNS in the Syrian golden hamster, a useful animal model for COVID-19.

9 Nov 2021

Invalidation of potential SARS-CoV-2 protease inhibitors

Researchers identified several structurally disparate compounds that can inhibit the viral protease PLpro and determined whether the identified PLpro inhibitors are truly effective and should be further investigated.

9 Nov 2021

Research opens the door to new therapeutic options for Parkinson's disease

These advances have been reported in a new scientific article published in the international journal Nature, fruit of the collaboration between Northwestern University (Chicago), Weill Cornell Medical College (New York) and the Institute of Biomedicine of Seville HUVR/CSIC/US/ and Ciberned.

8 Nov 2021

Do traumatic brain injuries in pregnant mothers impact fetal development?

In this interview, we spoke to Dr. Jonathan Lifshitz about his latest research into traumatic brain injuries and how they can affect an unborn child's development.

8 Nov 2021

$Non-thermal atmospheric pressure plasma heals bone fractures in animal bone defect models$

Non-thermal atmospheric pressure plasma heals bone fractures in animal bone defect models

Recent technological innovations which have allowed plasma to be generated at room temperature and at ambient atmosphere in what is called non-thermal atmospheric pressure plasma (NTAPP) have given scientists from Japan the opportunity to apply the therapeutic properties of this "fourth state of matter" to bone regeneration.

1 Nov 2021

New project investigates stem cell therapy as a potential treatment for glaucoma

Oregon Health & Science University is part of a national research project investigating stem cell therapy as a potential treatment for glaucoma, the world's second leading cause of blindness.

29 Oct 2021

$9 million grant from ASAP initiative to help advance research on Parkinson’s disease treatments

Researchers around the world have tried many ways, and for many years, to generate neurons in the lab so they could study them better. Neurons-on-demand might also provide a therapeutic option for replacing neurons lost in neurodegenerative conditions, such as Parkinson's disease.

27 Oct 2021

New mouse model shows that it is never too late to treat Hutchinson-Gilford Progeria Syndrome

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III and the Spanish Cardiovascular Research Network (CIBERCV), led by Dr Vicente Andrés, have generated the HGPSrev experimental mouse model.

26 Oct 2021

Using hydrogel barriers to effectively prevent post-surgical adhesions

Following surgery within the abdominal or pelvic cavities, scar tissue often forms on the inner linings of these cavities and may adhere to the organs which are found within them.

20 Oct 2021

Study reveals potential new approach to fight urinary tract infections

Identifying the dynamic events occurring during urinary tract infections (UTI) has revealed a new potential strategy to combat this condition, considered the most common type of infection.

19 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

The team has evaluated a low molecular weight chitosan derivative as a candidate preventing the viral entry into mammalian nasal epithelial cells to limit the spread of COVID-19.

12 Oct 2021

New approach to guided nerve repair by using gingiva-derived mesenchymal stem cells

A new approach to repairing peripheral nerves marries the regenerating power of gingiva-derived mesenchymal stem cells with a biological scaffold to enable the functional recovery of nerves following a facial injury, according to a study by a cross-disciplinary team from the University of Pennsylvania School of Dental Medicine and Perelman School of Medicine.

8 Oct 2021

Tiny bubbles show promise for reducing inflammation

Scientists hope that tiny sacs of material excreted by cells - so-called extracellular vesicles - can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport protein drugs that reduce inflammation caused by different diseases.

6 Oct 2021

Glycerin helps calm the red itchy patches in psoriasis model

Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combatting their psoriasis and now scientists have objective evidence to support their reports.

4 Oct 2021

Combination of two drugs may help pancreatic and liver cancer patients

A drug candidate discovered and developed decades ago in the laboratory of UC Davis distinguished professor Bruce Hammock may help control the body's raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

29 Sep 2021

Researchers develop new mouse model for studying non-Demented with Alzheimer’s disease

Alzheimer's is a neurodegenerative disease that features the accumulation of the beta-amyloid peptide and Tau protein in the brain, which are associated with deficits in the neuronal connections and with dementia.

28 Sep 2021

B cell activating anti-CD73 antibody for the immunotherapy of COVID-19

Despite the advent of numerous vaccines and the discovery of passive monoclonal antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there remains an urgent need for definitive therapies for coronavirus disease-2019 (COVID-19) patients.

27 Sep 2021

Researchers discover potential Achilles heel of pediatric acute myeloid leukemia

Researchers at Baylor College of Medicine and Texas Children's Hospital have uncovered a potential Achilles heel of acute myeloid leukemia (AML) in children that could lead to new treatments for this devastating disease.

23 Sep 2021

Breath measurements can be used to determine antibiotic concentrations in the body

A team of engineers and biotechnologists at the University of Freiburg has for the first time shown in mammals that the concentration of antibiotics in the body can be determined using breath samples. The breath measurements also corresponded to the antibiotic concentrations in the blood.

21 Sep 2021