Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in wild and domestic lower vertebrates (cattle, sheep, goats, camels, antelopes, and other herbivores), but it can also occur in humans when they are exposed to infected animals or tissue from infected animals.
Anthrax is most common in agricultural regions where it occurs in animals. These include South and Central America, Southern and Eastern Europe, Asia, Africa, the Caribbean, and the Middle East. When anthrax affects humans, it is usually due to an occupational exposure to infected animals or their products. Workers who are exposed to dead animals and animal products from other countries where anthrax is more common may become infected with B. anthracis (industrial anthrax). Anthrax outbreaks occur in the United States on an annual basis in livestock and wild game animals such as deer.
Anthrax infection can occur in three forms: cutaneous (skin), inhalation, and gastrointestinal. B. anthracis spores can live in the soil for many years, and humans can become infected with anthrax by handling products from infected animals or by inhaling anthrax spores from contaminated animal products. Anthrax can also be spread by eating undercooked meat from infected animals. It is rare to find infected animals in the United States.
Using gene transfer technology, investigators were able to immunize mice against anthrax in just 12 hours, according to new research featured in the February 2005 issue of Molecular Therapy, the peer-reviewed scientific journal of the American Society of Gene Therapy (ASGT).
A portable device similar to today's home pregnancy tests that can quickly detect the presence of infectious diseases, including HIV-AIDS and measles, as well as biological agents such as ricin and anthrax, is the object of a new joint university/industry research project.
Flu. Smallpox. Anthrax. Whooping cough. The words represent a veritable murderers' row of infectious agents whose death toll runs in the millions.
Rapidly distributing antibiotics to people exposed to anthrax spores during a bioterrorist attack, could by itself, prevent about 70 percent of anthrax infections from occurring, according to researchers from the Johns Hopkins Bloomberg School of Public Health.
MDX-1303 was developed by Medarex using its UltiMAb Human Antibody Development System, and this antibody is currently in preclinical development by Medarex for use against human anthrax infection.
Some individuals exhale many more pathogen-laden droplets than others in the course of ordinary breathing, scientists have found, but oral administration of a safe saline spray every six hours might slash exhalation of germs in this group by an average 72 percent.
From preventing polio to finding cures for cancer patients, animal research has saved countless lives.
VaxGen announced today that the U.S. government has awarded the company an $877.5 million contract to supply 75 million doses of anthrax vaccine for civilian defense.
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has awarded 14 contracts totaling more than $73 million to fund the Large-Scale Antibody and T Cell Epitope Discovery Program, an initiative aimed at quickly identifying the regions of selected infectious agents that elicit immune reactions.
Scientists at Imperial College London and Hammersmith Hospital are to help develop new vaccines in case of a terrorist release of biological agents such as anthrax.
A new report released today (25 October 2004) by the BMA paints a bleak picture of the global community's ability to cope with advances in biological and genetic weapons technology.
British scientists have developed a tabletop DNA test laboratory that can cut the diagnosis of disease and infection from hours to 30 minutes. This new test laboratory will soon begin trials in UK hospitals.
Prescriptions for antibiotics that could be taken in advance to prevent against anthrax were uncommon among concerned patients after September 11, 2001 and the 2001 U.S. anthrax attacks, according to an article in the October 11 issue of The Archives of Internal Medicine.
This week’s lead editorial in THE LANCET discusses the benefits and potential risks of allowing genomic information to be freely available on the internet
Scientists have traced the first steps in the way some new diseases emerge, and how harmless bacteria living in insects become dangerous disease-causing bugs which can affect humans, like the plague or anthrax.
Tiny types of soil bugs already make many of the products we use in washing detergents, foods, and waste treatment, but scientists now hope that similar bacteria will also make the vaccines and drugs of the future
The new bug-smashing technique uses the bacteria’s own natural enemies, tiny viruses called bacteriophages (or phages), which can infect bacterial cells. The phages make thousands of copies of themselves inside infected bacteria, but then need to dissolve the bacteria’s cell wall to get out and infect other bacterial cells.
The compulsory use of vaccines to prevent the effects of a bioterrorist attack seems to be based on an unproved threat, according to an editorial in this week's BMJ.
While nearly three-quarters of Americans believe that the public health system would respond fairly in a bioterrorist event, African-Americans and Asians adhere to this view in smaller proportions, perhaps because of past discriminatory policies put in place by health officials, according to a new UCLA study.
Researchers have developed a powdered form of an anthrax vaccine that could potentially be inhaled through the nose and eliminate the need for needle injections.
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