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Study uncovers new mechanism for chromosome congression during mitosis

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell division. The study demonstrates that two motor proteins, KIF18A and CENP-E, act cooperatively to ensure proper chromosome congression. Remarkably, simultaneous inhibition of these proteins selectively kills cancer cells, suggesting a promising therapeutic avenue.

10 Nov 2025

Micro-RNA in sperm proves vital for human embryogenesis

The sperm is not a passive supplier of genetic material to the egg. A study from Linköping University, Sweden, shows that certain molecules that come with the sperm, so-called micro-RNA, contribute to the development of the embryo several days after conception. The findings, published in the journal Nature Communications, may in the long term contribute to better diagnosis and treatment of involuntary childlessness.

10 Nov 2025

New drug combination gains Fast Track Designation for metastatic colorectal cancer

The U.S. Food and Drug Administration has granted Fast Track Designation to a new drug combination for metastatic colorectal cancer, following encouraging results from a clinical trial led in part by the University of Oklahoma Health Stephenson Cancer Center.

10 Nov 2025

GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

In youth newly diagnosed with type 2 diabetes, GLP-1–based therapies, including semaglutide and tirzepatide, achieved similar blood sugar control but significantly greater reductions in body mass index than metformin. These findings highlight the potential of high-potency GLP-1 agents as effective monotherapy options in managing obesity and glycemic control in adolescents.

10 Nov 2025

Study finds reduced cortical choline levels in people with anxiety disorders

People with anxiety disorders have lower levels of choline in their brains, according to research from UC Davis Health.

10 Nov 2025

Study provides insights into the obesity–breast cancer link

Obesity and cancer are two major health challenges of our time, yet the link between them remains only partially understood.

10 Nov 2025

Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes

Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in fat cells and may result in type 2 diabetes in people with obesity.

10 Nov 2025

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available.

10 Nov 2025

Groundbreaking vaccination approach could transform respiratory disease prevention

A research team from Trinity College Dublin has unveiled a groundbreaking new approach to vaccination that could redefine how we protect against respiratory infections.

10 Nov 2025

Genetic and cellular mechanisms underlying steatotic liver disease

Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), has emerged as the dominant cause of chronic liver disease worldwide, displacing viral hepatitis as the primary aetiology.

10 Nov 2025

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Regular orange juice consumption reprograms immune-cell gene activity linked to blood pressure, lipid metabolism, and inflammation in healthy adults. The molecular effects differ by body weight, suggesting BMI-tailored benefits from this everyday beverage.

9 Nov 2025

Studies uncover two novel, critical strategies for bacterial surface movement

New studies from Arizona State University reveal surprising ways bacteria can move without their flagella - the slender, whip-like propellers that usually drive them forward.

8 Nov 2025

Condensate-based strategy protects synthetic gene circuits across cell generations

Genetic engineers can design and assemble sophisticated gene circuits to program cells with new functions, but important signaling molecules can become diluted as these cells grow and divide, causing the synthetic gene circuits to lose their new functions.

7 Nov 2025

Protein linked to cancer plays key role in wound healing

When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions.

7 Nov 2025

New molecule offers a promising avenue to treat triple-negative breast cancer

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer - a form of cancer that is notoriously aggressive and lacks effective treatments.

7 Nov 2025

New NIH grants fuel research in oral cancer treatment and pain relief

Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, have been awarded three multi-year grants totaling $6 million from the National Institutes of Health to address treatment and pain management for oral cancer.

7 Nov 2025

Harnessing nanotechnology to deliver CBD to the brain for neuropathic pain relief

Reaching for CBD-infused lotion or oil may seem like a low-risk way to find pain relief, but little is actually known about the impact that CBD has on the nervous system.

7 Nov 2025

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients through a collaboration with Boston Children's Hospital.

7 Nov 2025

Rockefeller scientists engineer next-generation antibody to replace IVIG therapy

Intravenous immunoglobulin (IVIG) therapy involves infusing patients with naturally occurring IgG antibodies to treat autoimmune conditions.

7 Nov 2025

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection.

7 Nov 2025

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B Cell News and Research

Study uncovers new mechanism for chromosome congression during mitosis

Micro-RNA in sperm proves vital for human embryogenesis

New drug combination gains Fast Track Designation for metastatic colorectal cancer

GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

Study finds reduced cortical choline levels in people with anxiety disorders

Study provides insights into the obesity–breast cancer link

Weill Cornell scientists discover early step in fat cell inflammation leading to diabetes

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

Groundbreaking vaccination approach could transform respiratory disease prevention

Genetic and cellular mechanisms underlying steatotic liver disease

Drinking orange juice daily may fine-tune genes tied to cardiovascular wellness

Studies uncover two novel, critical strategies for bacterial surface movement

Condensate-based strategy protects synthetic gene circuits across cell generations

Protein linked to cancer plays key role in wound healing

New molecule offers a promising avenue to treat triple-negative breast cancer

New NIH grants fuel research in oral cancer treatment and pain relief

Harnessing nanotechnology to deliver CBD to the brain for neuropathic pain relief

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Rockefeller scientists engineer next-generation antibody to replace IVIG therapy

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

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