Lymphocyte News and Research

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Researchers provide insight into unintended consequence of immune checkpoint inhibitors

Immune checkpoint inhibitors are an emerging type of cancer immunotherapy that uses the immune system to attack cancer cells.

12 Jun 2019

Combination immunotherapy shows promise in pre-surgical setting for early-stage lung cancers

Neoadjuvant, or pre-surgical, treatment with nivolumab plus ipilimumab resulted in an overall major pathologic response rate of 33 percent of treated patients with early-stage, resectable non-small cell lung cancers, meaning these patients had less than or equal to 10 percent viable tumor remaining at surgery.

3 Jun 2019

Researchers discover COMMD3/8 protein complex as molecule involved in immune cell migration

A team of researchers led by Kazuhiro Suzuki from the Immunology Frontier Research Center at Osaka University discovered the COMMD3/8 complex as a molecule involved in immune cell migration, clarifying that the complex plays a critical role in the establishment of immune responses.

31 May 2019

Combination of biological markers and genetic changes can predict radiation sensitivity

Latest results from a project to discover what makes a cancer patient more likely to suffer adverse side-effects after radiotherapy have shown that a combination of biological markers and certain genetic changes can predict radiation sensitivity.

30 Apr 2019

Study describes new viral molecular evasion mechanism used by cytomegalovirus

A study published in the journal PLOS Pathogens describes a new viral molecular evasion mechanism used by cytomegalovirus to interfere in the immune response of the infected host.

30 Apr 2019

Researchers find presence of Aire gene in lymph nodes

The thymus is the organ in which T cells differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses.

11 Apr 2019

Research findings change misconception on white blood cell trafficking to spleen

Contrary to prior belief, the white blood cells enter the spleen primarily via vessels in the red pulp. The research results change thoroughly our perception of the spleen producing antibodies vital for the human body.

3 Apr 2019

FDA approves new oral drug to treat relapsing forms of multiple sclerosis

The U.S. Food and Drug Administration today approved Mavenclad (cladribine) tablets to treat relapsing forms of multiple sclerosis (MS) in adults, to include relapsing-remitting disease and active secondary progressive disease.

29 Mar 2019

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood.

1 Mar 2019

Study uncovers potential role of Foxp1 protein in control of autoimmune diseases

Scientists at the Higher School of Economics, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and the Memorial Sloan Kettering Cancer Center created a genetic model that helps to understand how the body restrains autoimmune and oncological diseases.

26 Feb 2019

Customizing the Cellular Microenvironment to Improve Physiological Relevance

An interview with Marie-Charlotte Manus, discussing a new technology called PRIMO that improves the physiological relevance of cells in culture.

From Alveole 18 Feb 2019

Study opens new avenue for treating ulcerative colitis or Crohn's disease

An international study led by the Complutense University of Madrid (UCM) and the National Centre for Cardiovascular Research (CNIC) has found that Lactobacillus bacteria present in the intestinal microbiota interact with immune system cells to strengthen the intestinal barrier.

31 Jan 2019

New evidence shows how fever alters immune cells

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how.

16 Jan 2019

Expression of a molecule in blood cells inversely predicts appearance of subclinical atherosclerosis

Earlier detection of cardiovascular disease is a step closer thanks to the findings of a research team at the Centro Nacional de Investigaciones Cardiovasculares led by Francisco Sánchez-Madrid and Pilar Martín.

10 Jan 2019

Lupin partners with Abbvie to develop and commercialize new targeted oncology treatments

Pharma major Lupin Limited and global biopharmaceutical company AbbVie Inc., today announced that AbbVie has licensed Lupin's MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) inhibitor program.

25 Dec 2018

New approach to destroy HIV reservoirs

Current HIV treatments need to be taken for life by those infected as antiretroviral therapy is unable to eliminate viral reservoirs lurking in immune cells. Institut Pasteur scientists have identified the characteristics of CD4 T lymphocytes that are preferentially infected by the virus - it is their metabolic (or energy-producing) activity1 that enables the virus to multiply.

21 Dec 2018

Findings may open up new ways to treat dwarfism and other ER-stress-related conditions

Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition characterized by disproportionate short stature, joint laxity, pain, and early onset osteoarthritis.

12 Dec 2018

Scientists discover cellular mechanism that triggers pneumonia in humans

The situation is relatively common, especially in winter. You come down with the flu, which lasts longer than usual. A few days later, you discover you have pneumonia.

10 Dec 2018

Scientists develop new surgical process for studying the thymus

Elisa Oltra, head of the Genetic Exppression and Immunity group of the Faculty of Medicine at the Catholic University of Valencia, in collaboration with Alejandro Caicedo, professor of the Department of Medicine of the University of Miami, have developed a surgical process which makes it possible to place functional fragments of the thymus in the anterior chamber of the eyes of mice.

26 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018