Malignant News and Research

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New method can kill aggressive brain tumors

Researchers at the University of Gothenburg, working with French colleagues, have successfully developed a method able to kill the aggressive brain tumor glioblastoma.

25 May 2023

Deep learning–based computer-aided diagnosis for breast lesion classification

According to an accepted manuscript published in ARRS' own American Journal of Roentgenology (AJR), deep learning–based computer-aided diagnosis (CAD) for breast lesion classification on ultrasound significantly improved radiologists' diagnostic performance - particularly for reducing the frequency of benign breast biopsies.

25 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Exploring how and why nitrate has contrasting potential risks and benefits

Despite our understanding of nutrition expanding remarkably in recent times, few aspects of our diet continue to confuse and divide the experts like nitrate.

22 May 2023

Cancer researchers join together to fight lethal childhood brain cancer

Virginia Tech researchers with the Fralin Biomedical Research Institute at VTC have joined a Children's National Hospital effort to treat deadly brain tumors with ultrahigh frequency sound waves.

22 May 2023

Research findings bring order to the genomic chaos of ovarian high grade serous carcinoma

New research findings based on the evolution of malignant tumors increase our understanding of the characteristics of an ovarian cancer subtype that is difficult to treat.

19 May 2023

Long-term ketogenic diet boosts survival rates in advanced cancer patients

Long-term ketogenic diet shows improved survival rates in cancer patients, with a significantly better overall survival for those following the diet for ≥12 months. Promising results for cancer therapy.

18 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Researchers discover key epigenetic alteration associated with clinical course of liver cancer

Researchers at the Josep Carreras Leukaemia Research Institute, led by Dr. Manel Esteller, have discovered a key epigenetic alteration that anticipates the clinical course of liver cancer.

16 May 2023

Break Through Cancer funds AML research at MD Anderson

The University of Texas MD Anderson Cancer Center was awarded more than $5.7 million in grants from Break Through Cancer to support collaborative research teams working to discover novel molecular targets to eradicate minimal residual disease in acute myeloid leukemia (AML) and to treat clonal hematopoiesis, a precursor to AML.

16 May 2023

Non-coding genetic molecules may hold promise for warning of esophageal cancer

Irregularities in the body's genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn't clear.

15 May 2023

Brain cancer cells communicate with astrocytes to enhance tumor growth by energy transfer

Malignant brain tumors belong to a group of cancers with bleak prognosis. These tumors are resistant to treatment and considered incurable.

15 May 2023

Research sheds light on the early cellular events that give rise to pancreatic cancer

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

11 May 2023

Silenced p16 gene can drive colorectal cancer progression

Colorectal cancer is the fourth most common and second deadliest cancer. How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models.

10 May 2023

Can artificial intelligence help predict the risk of pancreatic cancer using disease trajectories?

Researchers designed surveillance programs for the early detection of patients at elevated risk of pancreatic cancer.

10 May 2023

High-grade gliomas remodel neural circuits: promoting tumor progression and impaired cognition

Researchers investigated whether functional connectivity between glioblastoma and the brain affected neural circuits.

9 May 2023

Organoids derived from cancer cells can reduce the need for trial and error in identifying effective treatments

Researchers created organoids from cancer cells to reduce the need for trial and error in identifying effective cancer treatments in one of many cancer studies scheduled for presentation this week at Digestive Disease Week (DDW) 2023.

8 May 2023

Combination treatment shows promise for aggressive subtype of non-Hodgkin lymphoma

Nearly 90 percent of patients with an aggressive subtype of non-Hodgkin lymphoma had their cancer go into remission in a small phase 2 clinical trial testing a treatment aimed at making chemotherapy more effective, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

5 May 2023

Study evaluates simultaneous effects of exercise and diet-induced weight reduction in patients with type 2 diabetes

Researchers performed a four-armed, 16-week randomized clinical trial on type II diabetes.

3 May 2023

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

Malignant News and Research

New method can kill aggressive brain tumors

Deep learning–based computer-aided diagnosis for breast lesion classification

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Exploring how and why nitrate has contrasting potential risks and benefits

Cancer researchers join together to fight lethal childhood brain cancer

Research findings bring order to the genomic chaos of ovarian high grade serous carcinoma

Long-term ketogenic diet boosts survival rates in advanced cancer patients

Mast cells play a crucial role in the development of chronic myeloid leukemia

Researchers discover key epigenetic alteration associated with clinical course of liver cancer

Break Through Cancer funds AML research at MD Anderson

Non-coding genetic molecules may hold promise for warning of esophageal cancer

Brain cancer cells communicate with astrocytes to enhance tumor growth by energy transfer

Research sheds light on the early cellular events that give rise to pancreatic cancer

Silenced p16 gene can drive colorectal cancer progression

Can artificial intelligence help predict the risk of pancreatic cancer using disease trajectories?

High-grade gliomas remodel neural circuits: promoting tumor progression and impaired cognition

Organoids derived from cancer cells can reduce the need for trial and error in identifying effective treatments

Combination treatment shows promise for aggressive subtype of non-Hodgkin lymphoma

Study evaluates simultaneous effects of exercise and diet-induced weight reduction in patients with type 2 diabetes

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

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