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Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma.

23 Oct 2017

Researchers identify new molecular pathway that controls aging in worms

Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals.

13 Oct 2017

MIT researchers develop new technique to screen for genes that protect against diseases

Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases.

12 Oct 2017

Study sheds light on complex process involved in development of sperm stem cells

New research from scientists at Huntsman Cancer Institute at the University of Utah and collaborators at University of Utah Health sheds light on the complex process that occurs in the development of human sperm stem cells.

5 Oct 2017

GW researcher awarded NIH grant to study how cocaine use affects HIV infection

Following studies showing that cocaine influences the replication and transcription of HIV, a researcher at the George Washington University School of Medicine and Health Sciences was awarded more than $2.3 million from the National Institutes of Health to look deeper into the involved molecular mechanisms that allow this effect to happen.

5 Oct 2017

Drug combination produces synergistic effect against growth of triple-negative breast cancer

In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death.

26 Sep 2017

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice.

26 Sep 2017

Research provides insight into how imbalance in neural precursor cells may contribute to brain diseases

Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce neurons.

15 Sep 2017

Heidelberg researchers gain new insights into formation of blood vessels

New insights into the development of the vascular system: researchers in the team of Dr Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center have discovered a crucial biological step that regulates the formation of blood vessels.

15 Sep 2017

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors. The study appears in the journal Nature Neuroscience.

13 Sep 2017

TSRI scientists find new approach to reprogram ordinary adult cells into IPSCs

Scientists at The Scripps Research Institute have found a new approach to the "reprogramming" of ordinary adult cells into stem cells.

12 Sep 2017

Scientists uncover how gut bacteria and body clock work together to promote fat accumulation

UT Southwestern researchers have uncovered new clues about how gut bacteria and the body's circadian clock work together to promote body fat accumulation.

12 Sep 2017

PXi multi-application imager used for new fluorescent peptide imaging application

Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce its PXi multi-application imager is being used by scientists at the prestigious Freie Universtät Berlin for the new application of imaging fluorescent peptides on Western blots.

From Syngene 8 Sep 2017

Scientists directly convert skin cells from healthy adults into motor neurons

Scientists working to develop new treatments for neurodegenerative diseases have been stymied by the inability to grow human motor neurons in the lab. Motor neurons drive muscle contractions, and their damage underlies devastating diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy, both of which ultimately lead to paralysis and early death.

7 Sep 2017

Transcription Factors News and Research

Penn researchers provide new insights into how Notch drives growth of B-cell cancers

Researchers identify new molecular pathway that controls aging in worms

MIT researchers develop new technique to screen for genes that protect against diseases

Study sheds light on complex process involved in development of sperm stem cells

GW researcher awarded NIH grant to study how cocaine use affects HIV infection

Drug combination produces synergistic effect against growth of triple-negative breast cancer

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Research provides insight into how imbalance in neural precursor cells may contribute to brain diseases

Heidelberg researchers gain new insights into formation of blood vessels

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

TSRI scientists find new approach to reprogram ordinary adult cells into IPSCs

Scientists uncover how gut bacteria and body clock work together to promote fat accumulation

PXi multi-application imager used for new fluorescent peptide imaging application

Scientists directly convert skin cells from healthy adults into motor neurons

Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape

Researchers reveal reason for reduced release of satiety hormones in obese people

Biomedical engineering researchers aim to attack two banes of cardiovascular disease

Researchers uncover novel role for Gata4 in reducing post-heart attack fibrosis

Dendritic-specific Golgi plays key role in early neuropathy of degenerative brain disease

Study demonstrates potential nanoparticle-based therapeutic strategy for deadly brain tumors

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