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Investigational antiviral superior to standard of care for treating COVID-19 patients

The investigational antiviral remdesivir is superior to the standard of care for the treatment of COVID-19, according to a report published today in The New England Journal of Medicine.

27 May 2020

Montefiore and Einstein evaluate a new drug combination to fight COVID-19

Montefiore Health System Albert Einstein College of Medicine have begun the next stage of the Adaptive COVID-19 Treatment Trial (ACTT), to evaluate treatment options for people hospitalized with severe COVID-19 infection.

26 May 2020

Novel testing system predicts outcomes in patients with sepsis

More than 1.7 million Americans develop sepsis each year, and more than 270,000 die from it. The condition--which happens when the body has an extreme response to a bacterial or viral infection, causing a chain reaction that can lead to organ failure and death--has few strategies for treatment.

26 May 2020

First COVID-19 vaccine found to be safe, able to generate rapid immune response in phase 1 clinical trial

The first COVID-19 vaccine to reach phase 1 clinical trial has been found to be safe, well-tolerated, and able to generate an immune response against SARS-CoV-2 in humans, according to new research published in The Lancet.

22 May 2020

Supportive care for reducing fatigue may not be sufficiently adhered to by breast cancer patients

Cancer-related fatigue is a prevalent and potentially persistent issue among breast cancer survivors, which can prevent them from returning to their previous life well after treatment ends and they are declared free of disease.

22 May 2020

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

Two novel biomarkers have been found to correlate with improved outcomes with immunotherapy in metastatic breast cancer and may help to identify the patients most likely to benefit from this treatment, according to exploratory studies reported at the ESMO Breast Cancer Virtual Meeting 2020.

22 May 2020

RYGB surgery patients can benefit from anti-obesity medications

Researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery, according to a retrospective study published online in Obesity, the flagship journal of The Obesity Society.

22 May 2020

Blood test could reveal how the immune system responds to coronavirus

A highly detailed analysis of the composition of immune cells in the blood of patients with COVID-19, reveals new aspects of how the SARS-Cov-2 coronavirus causes disease.

22 May 2020

New clinical trial to test treatment that targets overactive immune response to COVID-19

For some COVID-19 patients, the body's immune response may be as destructive as the virus that causes the disease.

22 May 2020

Despite low stroke rates among COVID-19 patients, cases are still more severe

The rate of strokes in COVID-19 patients appears relatively low, but a higher proportion of those strokes are presenting in younger people and are often more severe compared to strokes in people who do not have the novel coronavirus.

22 May 2020

Simple molecular 'switch' transforms autoimmunity drugs into powerful anti-cancer treatments

Scientists from the Antibody and Vaccine group at the University of Southampton have discovered a way to transform antibody drugs previously developed to treat autoimmunity into antibodies with powerful anti-cancer activity through a simple molecular "switch".

21 May 2020

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, and Celonic Group, a premium biopharmaceutical CDMO specialized in the development and production of Advance Therapy Medicinal Products (ATMPs) and mammalian cell line-expressed biotherapeutics, today announced a collaboration to produce the novel human recombinant protein AT-100 (rhSP-D) as a therapeutic candidate against COVID-19.

21 May 2020

Excessive blood clotting and stroke in COVID-19 patients

The coronavirus disease COVID-19 is causing excessive blood clotting and stroke in young and healthy people, a new study has found.

21 May 2020

Just a little physical activity can have big impact for women with high-risk breast cancer

Results of a comprehensive analysis of exercise and its protective role for high-risk breast cancer patients show that women who exercise not only live longer, but also are more likely to remain cancer-free after their treatment. What's more, the study suggests that even a modest amount of exercise can be beneficial.

21 May 2020

LLNL engineers address shortage of nasopharyngeal swabs for COVID-19

In this era of COVID-19, tracking the disease adequately enough to allow state and local officials to lift shelter-in-place orders and return to a semblance of normalcy in the absence of a vaccine will require widespread testing, according to medical experts.

21 May 2020

Comprehensive review of clioquinol drug gives valuable insights

CQ is an old drug that was commonly used to treat fungal/protozoal infections of the gastrointestinal tract. Patients in Japan taking it developed subacute myelo-optic neuropathy which resulted in CQ being discontinued for oral use. Recently, extensive research has been done in regards to CQ's use for cancer treatment.

21 May 2020

MIT researchers describe new methods for accelerating drug approvals during pandemics

In response to the COVID-19 pandemic, researchers from the Massachusetts Institute of Technology have published a pair of studies in a COVID-19 special issue of the Harvard Data Science Review, freely available via open access, describing new methods for accelerating drug approvals during pandemics and for providing more accurate measures of the probabilities of success for clinical trials of vaccines and other anti-infective therapies.

20 May 2020

FDA approves IND application by Octapharma USA for severe COVID-19 patients

The U.S. Food and Drug Administration (FDA) has approved the investigational new drug (IND) application submitted by Octapharma USA for a phase three clinical trial on the efficacy and safety of Octagam 10% [Immune Globulin Intravenous (Human)] therapy in COVID-19 patients with severe disease progression.

20 May 2020

Dana-Farber launches clinical test of blood cancer drug in COVID-19 patients

Scientists at Dana-Farber Cancer Institute have launched a clinical test of a blood cancer drug in patients infected with the COVID-19 virus. T

20 May 2020

New collection of mobile apps reduces anxiety and depression during COVID-19

Terrified you will contract COVID-19? Feeling down, lonely and wondering when you'll be able to safely see your friends in person again?

20 May 2020

Clinical Trial News and Research

Investigational antiviral superior to standard of care for treating COVID-19 patients

Montefiore and Einstein evaluate a new drug combination to fight COVID-19

Novel testing system predicts outcomes in patients with sepsis

First COVID-19 vaccine found to be safe, able to generate rapid immune response in phase 1 clinical trial

Supportive care for reducing fatigue may not be sufficiently adhered to by breast cancer patients

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

RYGB surgery patients can benefit from anti-obesity medications

Blood test could reveal how the immune system responds to coronavirus

New clinical trial to test treatment that targets overactive immune response to COVID-19

Despite low stroke rates among COVID-19 patients, cases are still more severe

Simple molecular 'switch' transforms autoimmunity drugs into powerful anti-cancer treatments

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Excessive blood clotting and stroke in COVID-19 patients

Just a little physical activity can have big impact for women with high-risk breast cancer

LLNL engineers address shortage of nasopharyngeal swabs for COVID-19

Comprehensive review of clioquinol drug gives valuable insights

MIT researchers describe new methods for accelerating drug approvals during pandemics

FDA approves IND application by Octapharma USA for severe COVID-19 patients

Dana-Farber launches clinical test of blood cancer drug in COVID-19 patients

New collection of mobile apps reduces anxiety and depression during COVID-19

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