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Research opens possibility of developing single-dose gene therapy for inherited arrhythmias

Researchers at Boston Children's Hospital report creating the first human tissue model of an inherited heart arrhythmia, replicating two patients' abnormal heart rhythms in a dish, and then suppressing the arrhythmia with gene therapy in a mouse model.

17 Jul 2019

Novel biomarker-guided approach has potential for treatment of common liver cancer

A study at The University of Texas MD Anderson Cancer Center discovered a cellular pathway tied to cancer that may be beneficial in reducing side effects and extending duration of immunotherapy in some patients with hepatocellular carcinoma, the most common form of liver cancer.

16 Jul 2019

New hope for restoring sight in victims of acid attacks or industrial accidents

A revolutionary approach to treating chemical burns in the eye is beginning a clinical trial.

15 Jul 2019

Nanoparticles used to deliver CRISPR gene editing tools into the cell

Researchers from Tufts University and the Chinese Academy of Sciences have developed a novel method to effectively deliver the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) gene editing tools into the liver for genetic studies.

15 Jul 2019

New protein target for deadly ovarian cancer

A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract.

14 Jul 2019

Genetic contribution to distractibility helps explain procrastination

Wouldn’t it be nice to blame your genes for your procrastination? Now, using a combination of questionnaires and genetic testing, German researchers have found that with increasing dopamine in the brain, women tended to show greater tendencies to procrastinate.

14 Jul 2019

How cell-free DNA can be targeted to prevent spread of tumors

Cell-free DNA (cfDNA) is DNA found in trace amounts in blood, which has escaped degradation by enzymes.

12 Jul 2019

Metabolic enzyme tied to obesity and fatty liver disease

A team of researchers at the Clemson University found that Cyp2b gene, which metabolizes endo and xenobiotics, may be linked to age-onset obesity and dyslipidemia, especially in males.

11 Jul 2019

Researchers identify potential drug target for multiple cancer types

A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and their uncontrolled growth.

11 Jul 2019

Study finds new way to enhance regenerative potential of aged intestine

Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age.

11 Jul 2019

Sorting protein in neurons protects against neurodegenerative disorders

Like a sorting machine in an assembly line, a molecule known as VPS35 detects and removes defective proteins from neurons.

10 Jul 2019

Researchers pinpoint treatment target for rare liver cancer in adolescents, young adults

New findings show how a genetically aberrant, fused protein promotes a rare form of liver cancer in adolescents and young adults. The researchers also saw that a certain mix of drugs could target the fused protein and the enzymes that it recruits.

10 Jul 2019

Virus killing protein could be the real antiviral hero finds study

Researchers have identified a protein that can kill viruses and it forms the missing clue to the natural antiviral mechanism of the body that can target the viruses based on their genetic patterns. This newly identified protein is called KHNYN.

9 Jul 2019

Researchers capture high-resolution, 3D images of gene-editing enzymes

For the first time, scientists have captured high-resolution, three-dimensional images of an enzyme in the process of precisely cutting DNA strands.

9 Jul 2019

Novel anticancer agents show promise to control tumor growth in nearly every cancer type

A gene called MYC has become one of the hottest targets for cancer researchers around the world. MYC is known to drive tumor growth in nearly all cancer types - but successfully targeting the gene has proven to be a challenge.

9 Jul 2019

Uranium toxicity might have caused obesity and diabetes in Kuwait, finds new study

According to a new research report, the extremely high prevalence of diabetes and obesity in the Gulf nation of Kuwait might be linked to the very high levels of uranium in these individuals. This in turn could be associated with the large amounts of depleted uranium dumped here in the form of US munitions during the Gulf war of 1990-91.

9 Jul 2019

Antibiotic combination effective against drug-resistant Pseudomonas

Two well known and used antibiotics when combined have been found to be more effective against a deadly bacteria Pseudomonas aeruginosa, a common cause of hospital-based infections.

8 Jul 2019

Thioredoxin antioxidant could soon be used to improve cancer treatment

Researchers from Medical University of South Carolina (MUSC) have discovered the use of thioredoxin – a naturally occurring antioxidant to modulate T cells of the immune system. This may be a big step towards improving currently used immune therapies such as adoptive T-cell therapy (ACT) and hematopoietic stem cell transplantation (HSCT).

8 Jul 2019

Ludwig Cancer Research study discovers new cellular oxygen sensor

A Ludwig Cancer Research study led by Peter Ratcliffe and colleagues has discovered a previously overlooked oxygen sensor in animal cells that functions very much like one used by plants.

5 Jul 2019

A small chemical change reverses prediabetes in obese mice

A small chemical change - shifting the position of two hydrogen atoms - makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease.

5 Jul 2019