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Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear.

20 Feb 2024

“Laboratory testicles” could solve male infertility mysteries

The testis is responsible for sperm production and testosterone synthesis. Abnormalities in testis development and function lead to disorders of sex development (DSD) and male infertility. Currently, no in vitro system exists for modeling the testis.

20 Feb 2024

Study reveals novel mechanism for longevity of oocytes

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without incurring damage.

20 Feb 2024

Ultra-processed foods: A growing threat to public health

From fizzy drinks to cereals and packaged snacks to processed meat, ultra-processed foods are packed with additives.

20 Feb 2024

Novel genetic locations associated with primary open-angle glaucoma identified

An international genetic study using multiancestry biobanks has identified novel genetic locations associated with primary open-angle glaucoma (POAG), the most common type of glaucoma and the leading cause of irreversible blindness globally.

20 Feb 2024

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

20 Feb 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024

Fasting-mimicking diet reduces biological age and disease risks, study shows

Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat in humans, resulting in a lower biological age, according to a new USC Leonard Davis School of Gerontology-led study.

20 Feb 2024

Innovative computer model of the lung enables detailed simulation of radiation effects

An innovative computer model of a human lung is helping scientists simulate, for the first time, how a burst of radiation interacts with the organ on a cell-by-cell level.

20 Feb 2024

Researchers develop artificial cell environment to promote nerve regeneration

Injuries in the central nervous system heal poorly because cavities scar. Researchers hope to remedy this problem by filling the cavities in such a way that stem cells feel comfortable in them.

20 Feb 2024

MIP Discovery closes £7M Series A financing to drive commercialization in cell and gene therapy space

Company’s synthetic affinity reagents are antibody alternatives designed to advance the speed, safety, and efficiency of manufacturing at scale, making advanced therapies more accessible to patients.

From MIP Discovery 20 Feb 2024

Researchers develop novel nanomedicine loaded with genetic material to fight HIV

Society learned about the value of mRNA during the COVID-19 pandemic when we saw scientists and medical professionals harness its power to deliver a vaccine for the virus within a year.

20 Feb 2024

Missing gut microbes after antibiotics and a high-fat diet may be to blame for sugar-free candy and gum giving you gas

A recent Cell study showed how a high-fat diet and antibiotic exposure could trigger sorbitol intolerance by depleting Clostridia from the gut microbiota.

20 Feb 2024

Study discovers link between a breakdown product from excess niacin and heart disease

Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.

19 Feb 2024

Dietary protein overload linked to increased atherosclerosis risk

University of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk.

19 Feb 2024

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Researchers conducted clinical studies on murine animals and humans to evaluate the impact of high protein intake on the amino acid-mammalian target of the rapamycin complex 1 autophagy signaling pathway.

19 Feb 2024

Associations between food additive emulsifiers and cancer risk

Researchers assessed associations between food emulsifier intake and cancer risk among NutriNet-Santé study participants.

19 Feb 2024

Identification of genetic determinants of micronucleus formation

The genetic determinants of micronuclei formation (MN).

19 Feb 2024

Novel monoclonal antibody shows promise in targeting HER2-positive breast cancer cells

In a step forward for breast cancer treatment, researchers at Tohoku University have developed a novel monoclonal antibody which specifically targets a certain type of breast cancer cell.

19 Feb 2024

Discovery of novel enzyme family holds potential for antibiotic development

Researchers at Umeå University in Sweden, led by Professor Felipe Cava, have identified a new family of enzymes that creates a unique type of cross-linking between the building blocks of bacterial cell walls.

19 Feb 2024

B Cell News and Research

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

“Laboratory testicles” could solve male infertility mysteries

Study reveals novel mechanism for longevity of oocytes

Ultra-processed foods: A growing threat to public health

Novel genetic locations associated with primary open-angle glaucoma identified

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

Fasting-mimicking diet reduces biological age and disease risks, study shows

Innovative computer model of the lung enables detailed simulation of radiation effects

Researchers develop artificial cell environment to promote nerve regeneration

MIP Discovery closes £7M Series A financing to drive commercialization in cell and gene therapy space

Researchers develop novel nanomedicine loaded with genetic material to fight HIV

Missing gut microbes after antibiotics and a high-fat diet may be to blame for sugar-free candy and gum giving you gas

Study discovers link between a breakdown product from excess niacin and heart disease

Dietary protein overload linked to increased atherosclerosis risk

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Associations between food additive emulsifiers and cancer risk

Identification of genetic determinants of micronucleus formation

Novel monoclonal antibody shows promise in targeting HER2-positive breast cancer cells

Discovery of novel enzyme family holds potential for antibiotic development

Using single B cell screening to boost antibody discovery eBook

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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