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UMN study shows impact of opioids on pain and survival in sickle cell disease

New UMN research recently published Blood Advances, Kalpna Gupta, PhD, Professor of Medicine, University of Minnesota Medical School, demonstrates the impact of opioids on the survival of humanized mouse models with sickle cell disease, compared to normal mice.

3 Apr 2019

Unique 3D-printed transparent skull provides opportunity to watch brain activity in real time

Researchers at the University of Minnesota have developed a unique 3D-printed transparent skull implant for mice that provides an opportunity to watch activity of the entire brain surface in real time.

3 Apr 2019

Researchers developing new tests for early detection, monitoring of lupus nephritis

With $5 million in grants from the National Institutes of Health, two University of Houston biomedical researchers are moving the needle on early detection and monitoring of kidney nephritis, or inflammation, in patients who have Systemic Lupus Erythematosus, known simply as lupus.

2 Apr 2019

Study reveals new insights into genetic drivers of heavy drinking and alcohol use disorder

A large genomic study of nearly 275,000 people led by Penn Medicine researchers revealed new insights into genetic drivers of heavy drinking and alcohol use disorder, the uncontrollable pattern of alcohol use commonly referred to as alcoholism.

2 Apr 2019

Experts discover new offshoots of old health policy roots

As political leaders debate the future of the U.S. health care system, a pair of health financing experts discovered that all of the current proposals -- from Medicare for All to "repeal and replace" -- have been circulating in various forms since the 1940s.

2 Apr 2019

Early menopause raises bladder cancer risk for smokers

Early menopause increases the risk of bladder cancer for smokers - this was the finding of an interdisciplinary research group, led by urologist Mohammad Abufaraj from MedUni Vienna's Department of Urology and Division of Epidemiology and other international university hospitals, using data from 230,000 participants in the longitudinal Nurses' Health Studies I and II.

2 Apr 2019

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Human immunodeficiency virus, or HIV, attacks the immune system, making affected individuals more susceptible to infections. When patients with HIV are treated with antiretroviral therapy, their immune system can recover, but some of them produce self-destructive proteins, or autoantibodies.

2 Apr 2019

Researchers conduct largest study of childhood cancer after conception by IVF

In the past three decades, in vitro fertilization has gone from an experimental procedure to being more common. Pregnancies enabled by IVF frequently have more difficulties, with children born earlier and smaller even among singleton births.

2 Apr 2019

Study highlights need to diversify population-level genetic data for better disease prediction

Polygenic scores can predict a person's risk for conditions like coronary artery disease, breast cancer, and type 2 diabetes (T2D) with great accuracy, even in patients who lack common warning signs. This new genome analysis tool holds promise for physicians, who may be able to intervene earlier to help prevent common disease for at-risk individuals.

30 Mar 2019

Educating doctors alone may not have a noticeable effect on prescribing rates, study shows

Purely educating doctors about the importance of prescribing certain therapies may not be enough to make a meaningful impact, according to a new Penn Medicine study.

29 Mar 2019

New Hasso Plattner Institute for Digital Health launched at Mount Sinai

The Mount Sinai Health System and the Hasso Plattner Institute today announced an affiliation that brings together industry leaders with combined expertise in health care delivery, health sciences, biomedical and digital engineering, machine learning and artificial intelligence to rapidly develop digital health products with real-time predictive and preventive capabilities that empower patients and health care providers, and improve health and health outcomes.

29 Mar 2019

WHO guidelines for chronic hepatitis B fail to detect half of the patients in Ethiopia needing treatment

Current World Health Organization (WHO) guidelines for chronic hepatitis B (CHB) fail to detect half of the patients in need of treatment in Ethiopia, report scientists in the Journal of Hepatology, published by Elsevier.

29 Mar 2019

Researchers develop new strategy to treat sickle cell disease and beta thalassemia

Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of the most common inherited blood diseases -- sickle cell disease and beta thalassemia -- applying CRISPR-Cas9 gene editing to patients' own blood stem cells.

29 Mar 2019

New strategy for potential treatment of HBV associated liver cancer

Researchers from Duke-NUS Medical School, Singapore General Hospital and Lion TCR have demonstrated that they were able to engineer HBV-specific T cells, a type of immune cells found in the body, to treat Hepatocellular carcinoma, a commonly occurring liver cancer.

28 Mar 2019

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule is safe and nontoxic in mice and can significantly delay tumor formation and growth.

28 Mar 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

New discovery may explain low testosterone levels in men with diabetes

Scientists have mapped out how the body transports testosterone, and their surprising findings may explain low testosterone levels seen in men with diabetes or patients on certain medications.

28 Mar 2019

Treatment at low-scoring hospitals may increase risk for repeat heart attack and death

Heart attack patients treated at hospitals with low care scores are at greater risk for another heart attack and/or death due to cardiovascular causes, Rutgers researchers found.

27 Mar 2019

Tumor-associated macrophages block activity of chemotherapy drug in pancreatic cancer

A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug's action, research led by the University of Michigan Rogel Cancer Center found.

27 Mar 2019

Encapsulating human beta cells with immune-repelling protein restores glucose metabolism in diabetic mice

Encapsulating human stem-cell-derived beta cells in microcapsules made with a protein that repels key immune cells restored glucose metabolism in diabetic mice and protected the cells from immune system attack, preventing the buildup of inflammatory fibrotic tissue that has plagued previous trials of encapsulated beta cells.

27 Mar 2019

Medical School News and Research

UMN study shows impact of opioids on pain and survival in sickle cell disease

Unique 3D-printed transparent skull provides opportunity to watch brain activity in real time

Researchers developing new tests for early detection, monitoring of lupus nephritis

Study reveals new insights into genetic drivers of heavy drinking and alcohol use disorder

Experts discover new offshoots of old health policy roots

Early menopause raises bladder cancer risk for smokers

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Researchers conduct largest study of childhood cancer after conception by IVF

Study highlights need to diversify population-level genetic data for better disease prediction

Educating doctors alone may not have a noticeable effect on prescribing rates, study shows

New Hasso Plattner Institute for Digital Health launched at Mount Sinai

WHO guidelines for chronic hepatitis B fail to detect half of the patients in Ethiopia needing treatment

Researchers develop new strategy to treat sickle cell disease and beta thalassemia

New strategy for potential treatment of HBV associated liver cancer

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

New discovery may explain low testosterone levels in men with diabetes

Treatment at low-scoring hospitals may increase risk for repeat heart attack and death

Tumor-associated macrophages block activity of chemotherapy drug in pancreatic cancer

Encapsulating human beta cells with immune-repelling protein restores glucose metabolism in diabetic mice

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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