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FDA releases draft guidance on measuring patient-reported outcomes in cancer clinical trials

The following quote is attributed to Richard Pazdur, M.D., director of the FDA's Oncology Center of Excellence and acting director of the Office of Oncologic Diseases in the FDA's Center for Drug Evaluation and Research.

9 Jun 2021

Study reveals how high fat diets can cause intestinal and colon cancer

For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.

9 Jun 2021

Protein in prostate cancer may prevent tumor from spreading to the bone

Prostate cancer is the second most common cancer among men, according to the American Cancer Society. It's also one of the trickiest cancers to diagnose and treat.

9 Jun 2021

Microgel-coated mesenchymal stromal cells can reverse pulmonary fibrosis

Researchers at the University of Illinois Chicago have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells.

9 Jun 2021

Researchers clarify cellular processes related to radiation resistance of pancreatic cancer cells

Pancreatic cancer is one of the deadliest cancer subtypes not just because it is difficult to diagnose early, but because it is inherently resistant to chemotherapy and radiotherapy.

8 Jun 2021

ONK Therapeutics and Trinity researchers seek to improve cellular therapies for treating cancer

ONK Therapeutics Ltd, an innovative natural killer (NK) cell therapy company, today announced that it has been awarded an Innovation Partnership Programme grant by Enterprise Ireland (EI) to fund collaborative research at Trinity College Dublin, Ireland, led by Dr. David Finlay to optimize the metabolism and engineering of NK cells for improved cancer therapies.

8 Jun 2021

New study could help guide oncologists in selecting the best treatment for kidney cancers

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result.

8 Jun 2021

Wearable sensor shows link between blood pressure and intracranial pressure

Brazilian researchers have simultaneously demonstrated the mechanism linking high blood pressure to elevated intracranial pressure, validated a non-invasive intracranial pressure monitoring method, and proposed a treatment for high blood pressure that does not affect intracranial hypertension.

8 Jun 2021

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions.

8 Jun 2021

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Study shows how cowpea mosaic plant virus stimulates the immune system against cancer

Previous work by a team of researchers led by Steven N. Fiering, PhD, Immunology and Cancer Immunotherapy researcher at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center and Nicole Steinmetz, PhD, Jacobs School of Engineering and Moores Cancer Center, University of California San Diego, showed that a plant virus that does not infect mammals, cowpea mosaic plant virus (CPMV), when injected into cancerous tumors, strongly stimulated the immune system to attack and often eliminate the tumor.

8 Jun 2021

New drug shows promise against lung cancer caused by genetic mutation

The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial.

8 Jun 2021

Rice scientist wins NIH grant to model and analyze protein-ligand interactions in cancer research

Computer scientist Lydia Kavraki of Rice University's Brown School of Engineering has won a prestigious National Institutes of Health U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research.

7 Jun 2021

MRI-guided focused ultrasound advances brain and cancer research

By 2034, nearly one-quarter of Americans will have reached retirement age, according to the United States Census Bureau. But as people age, the brain becomes more susceptible to developing disorders, such as essential tremor, Parkinson's disease, and tumors.

7 Jun 2021

New drug reduces tumor size in lung cancer patients who have a specific, disease-causing change

A new drug reduced tumor size in patients who have lung cancer with a specific, disease-causing change in the gene KRAS, a study found.

7 Jun 2021

Researchers to develop new technology to detect and remove cancer tumors

New technology that will marry probes that can detect cancer tumors through the skin with high-precision robotic surgery is to be developed for use in hospital settings for the first time in a project led by the University of Warwick.

7 Jun 2021

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

In a recent open-access paper published in the Journal of Clinical Medicine, researchers from Iran and Germany show that high baseline levels of inflammatory cytokines measured during admission put patients with coronavirus disease (COVID-19) at increased risk of developing coagulopathy, thrombotic events – and even death.

6 Jun 2021

Tumor News and Research

FDA releases draft guidance on measuring patient-reported outcomes in cancer clinical trials

Study reveals how high fat diets can cause intestinal and colon cancer

Protein in prostate cancer may prevent tumor from spreading to the bone

Microgel-coated mesenchymal stromal cells can reverse pulmonary fibrosis

Researchers clarify cellular processes related to radiation resistance of pancreatic cancer cells

ONK Therapeutics and Trinity researchers seek to improve cellular therapies for treating cancer

New study could help guide oncologists in selecting the best treatment for kidney cancers

Wearable sensor shows link between blood pressure and intracranial pressure

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Study shows how cowpea mosaic plant virus stimulates the immune system against cancer

New drug shows promise against lung cancer caused by genetic mutation

Rice scientist wins NIH grant to model and analyze protein-ligand interactions in cancer research

MRI-guided focused ultrasound advances brain and cancer research

New drug reduces tumor size in lung cancer patients who have a specific, disease-causing change

Researchers to develop new technology to detect and remove cancer tumors

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

New treatment option offers disease control and extends life in patients with advanced prostate cancer

Maternal SARS-CoV-2 infection imprints immune response in the newborn

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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