Preclinical News and Research

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Research findings could lead to new treatments for lung disorders in premature babies

Researchers at Yale School of Medicine have made major discoveries that could lead to new treatments for lung disorders in premature babies. In a mouse study, the team located key molecules that switch on stress pathways in preterm lung disorders, and also found that when parts of these pathways were blocked with a pain drug, lung damage was prevented or reversed.

21 Mar 2013

New class of anti-malarial compounds discovered

A group of researchers from 16 institutions around the world has identified a new class of anti-malarial compounds that target multiple stages of the malaria parasite's life cycle.

21 Mar 2013

Eritoran drug does not reduce risk of death in patients with severe sepsis

Administration of the drug eritoran to patients with severe sepsis and septic shock failed to demonstrate a significant effect on reducing all-cause 28-day mortality or 1-year mortality, compared with placebo, according to a study in the March 20 issue of JAMA.

20 Mar 2013

European Congress on Osteoporosis & Osteoarthritis to start in April

Attend the European Congress on Osteoporosis & Osteoarthritis Rome, Italy from April 17-20, 2013 and earn up to 19 European Accreditation Council for Continuing Medical Education credits.

20 Mar 2013

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Researchers at the University of Maryland School of Medicine have identified a peptide, or protein, derived from Pacific cod that may inhibit prostate cancer and possibly other cancers from spreading, according to preclinical research published online in the Proceedings of the National Academy of Sciences.

20 Mar 2013

New research project on systems biology of synapse proteins and ageing launched

The AgedBrainSYSBIO project on systems biology of synapse proteins & ageing was officially launched March18th in Paris, France.

20 Mar 2013

Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Alnylam Pharmaceuticals a leading RNAi therapeutics company, announced today that it has initiated dosing in its Phase I clinical trial with ALN-TTRsc, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR).

19 Mar 2013

Controlling hypertension earlier in life may limit brain changes associated with Alzheimer's disease

A study in the JAMA Neurology (formerly the Archives of Neurology) suggests that controlling or preventing risk factors such as hypertension earlier in life may limit or delay the brain changes associated with Alzheimer's disease and other age-related neurological deterioration.

19 Mar 2013

Bruker introduces new products with scientific capabilities for research, industrial and applied markets

At Pittcon 2013, Bruker today announced numerous new product introductions for research, industrial and applied markets, designed to deliver more confident analyses with increased sensitivity, specificity and productivity, as well as novel scientific capabilities which expand the boundaries of molecular and materials research.

19 Mar 2013

CHOP expert to receive Pediatric Oncology Award from ASCO

The American Society of Clinical Oncology today announced it will confer one of its highest awards on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children's Hospital of Philadelphia.

16 Mar 2013

ConservoCare obtains license options to develop nerve-block medical device for bladder control

ConservoCare, LLC, a spinoff of research at Case Western Reserve University, has obtained license options through the university's Technology Transfer Office to develop a medical device for bladder control.

16 Mar 2013

Max Planck Florida Institute for Neuroscience gets grant for research into neurological disorders

The Max Planck Florida Institute for Neuroscience, the first and only U.S. extension of the prestigious Max Planck Society, today announced it has received approximately $1,257,500 in grant funding from prestigious national and international organizations to fund research into Parkinson-s, epilepsy and other neurological disorders.

15 Mar 2013

Scientists to create new human monoclonal antibody targeting protein associated with cancer

Researchers have discovered a unique monoclonal antibody that can effectively reach inside a cancer cell, a key goal for these important anticancer agents, since most proteins that cause cancer or are associated with cancer are buried inside cancer cells.

14 Mar 2013

Scientists sign licensing agreement for anticancer substances

Most cancer patients die of the disease because tumor cells spread to other sites in the body and form new tumors, so-called metastases.

14 Mar 2013

Studies show local chemotherapy more effective in reducing tumor growth than regular chemotherapy

Reducing the growth of a tumor by localized delivery of cancer medication can be achieved by using a combination of ultrasound, temperature-sensitive nanoparticles and MRI.

14 Mar 2013

Adult stem cell treatment for diabetic wounds

Pre-clinical research has generated some very promising findings using adult stem cells for the treatment of diabetic wounds. The research carried out by scientists at the National University of Ireland Galway, is published in Diabetes, the official journal of the American Diabetes Association.

13 Mar 2013

Sleep problems may be indicator of early Alzheimer's disease

Sleep is disrupted in people who likely have early Alzheimer's disease but do not yet have the memory loss or other cognitive problems characteristic of full-blown disease, researchers at Washington University School of Medicine in St. Louis report March 11 in JAMA Neurology.

12 Mar 2013

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Antibodies and in the case of Ablynx, Nanobodies, can be raised and selected to bind with high affinity selectively to cancer cells in a tumour. Cancer cells are exquisitely sensitive to certain toxins such as the PBDs produced by Spirogen.

12 Mar 2013

Pneumococcal vaccine pre-clinical development supported by £0.2 million award from Biomedical Catalyst

ImmBio (Immunobiology Ltd), a biopharmaceutical company developing innovative vaccines against serious infectious diseases, today announced that the UK government-backed Biomedical Catalyst has awarded the company approximately £0.2 million ($0.3 million) to support pre-clinical development of its pneumococcal vaccine, PnuBioVax™, which targets a wide range of strains of the bacteria.

12 Mar 2013

$Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction$

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

Among patients with heart failure with preserved ejection fraction (a measure of heart function), administration of sildenafil for 24 weeks, compared with placebo, did not result in significant improvement in exercise capacity or clinical status, according to a study published online by JAMA.

12 Mar 2013

Preclinical News and Research

Research findings could lead to new treatments for lung disorders in premature babies

New class of anti-malarial compounds discovered

Eritoran drug does not reduce risk of death in patients with severe sepsis

European Congress on Osteoporosis & Osteoarthritis to start in April

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

New research project on systems biology of synapse proteins and ageing launched

Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Controlling hypertension earlier in life may limit brain changes associated with Alzheimer's disease

Bruker introduces new products with scientific capabilities for research, industrial and applied markets

CHOP expert to receive Pediatric Oncology Award from ASCO

ConservoCare obtains license options to develop nerve-block medical device for bladder control

Max Planck Florida Institute for Neuroscience gets grant for research into neurological disorders

Scientists to create new human monoclonal antibody targeting protein associated with cancer

Scientists sign licensing agreement for anticancer substances

Studies show local chemotherapy more effective in reducing tumor growth than regular chemotherapy

Adult stem cell treatment for diabetic wounds

Sleep problems may be indicator of early Alzheimer's disease

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Pneumococcal vaccine pre-clinical development supported by £0.2 million award from Biomedical Catalyst

Sildenafil does not improve exercise capacity in HF patients with preserved ejection fraction

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