Biochemistry News and Research

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Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration

Age-related macular degeneration (AMD) is one of the leading causes of vision loss in older adults and a person's risk may partly depend upon diet.

6 Jun 2006

Milstein gift seeks cure for antibiotic-resistant TB and malaria

A $7.25 million gift to Weill Medical College of Cornell University will establish the Abby and Howard P. Milstein Chemistry Core Facility and the Abby and Howard P. Milstein Program in Chemical Biology.

5 Jun 2006

COX-1 and COX-2 enzymes may be blocked by pain medications

COX-1 and COX-2 enzymes may be blocked by pain medications such as Advil and Vioxx in a more complex manner than was previously understood, a Queen's University study has found.

29 May 2006

NIH panel says little benefit to be gained by taking multivitamin supplements

According to a National Institutes of Health panel there is little evidence to support that taking multivitamin supplements is of any benefit to healthy adults.

21 May 2006

Panel calls for expanded oversight of vitamin and mineral supplements

An independent panel convened this week by the NIH Office of Medical Applications of Research and the Office of Dietary Supplements assessed the available evidence on the safety and effectiveness of multivitamin/minerals (MVMs).

17 May 2006

German scientists synthesize new compound that reduces stroke damage

A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms.

16 May 2006

Novel protein JHDM2A offers new look at male hormone regulation

For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.

8 May 2006

Discovery of gene that appears to play an important role in the onset of type 2 diabetes

In a painstaking set of experiments in overweight mice, scientists from the University of Wisconsin-Madison have discovered a gene that appears to play an important role in the onset of type 2 diabetes.

8 May 2006

Bacterial binding in the stomach

Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori. Blocking this interaction could lead to new drugs that reduce the risk of peptic ulcer disease or gastric cancer.

8 May 2006

DARPA grant supports research toward realizing tissue regeneration

While U.S. soldiers fighting in Iraq and Afghanistan are surviving injuries that in previous conflicts likely would have been fatal, the number of wounded with major tissue loss has never before been so high.

3 May 2006

Scientists create leaner and meaner E. coli

By stripping the E. coli genome of vast tracts of its genetic material - hundreds of apparently inconsequential genes - a team of Wisconsin researchers has created a leaner and meaner version of the bacterium that is a workhorse of modern biology and industry.

3 May 2006

Progressive histological damage in liver allografts following pediatric liver transplantation

A new study on the long-term outcome of children undergoing liver transplants found that chronic hepatitis (CH) was common and that it was not detectible using standard blood tests.

3 May 2006

Enzyme discovery could reduce Kaposi sarcoma tumour growth and lead to drugs suitable for treating other viral cancers

A report in the Journal of Biological Chemistry shows that inhibition of heme oxygenase-1, an enzyme involved in iron metabolism, reduces Kaposi sarcoma tumor growth. This discovery could result in the production of new drugs to treat this and other viral cancers.

28 Apr 2006

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study describes a new way to manipulate perhaps the most important signaling mechanism in human cells: G-protein coupled receptors (GPCRs).

28 Apr 2006

Alternative anti-inflammatory drugs promise less cardiovascular problems

New type of anti-inflammatory drugs may reduce COX-2 cardiovascular problems, says Queen's researcher

25 Apr 2006

Swedish ACI method of cartilage repair gives excellent durability

As the population ages, arthritis will become more prevalent. It would be helpful to know more about the causes and treatments of cartilage wear.

25 Apr 2006

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.

23 Apr 2006

Possible alternatives found for Vioxx and Celebrex

According to Canadian and American researchers they have identified one reason why drugs like Celebrex and Vioxx - once popular for the treatment of pain and inflammation - cause heart problems.

18 Apr 2006

Sticky proteins for neuro-chip chat

EU-funded researchers have taken the firsts steps towards future technologies combining silicon circuits and the nervous systems of mammals. Applications could include advanced drug screening and, perhaps one day, implants to help combat neurological disorders.

18 Apr 2006

Researchers determine factors that turn on protein production in bacteria

In the study, published in the journal Molecular Cell, researchers Sean Studer and Simpson Joseph in UCSD's Department of Chemistry and Biochemistry report how the messenger RNA instructions to make a protein are unfolded in a bacterial cell, so that they can be read by the cell's protein-making machinery.

11 Apr 2006