Clinical Trial News and Research

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New collaboration may lead to future clinical trials to test treatment for leukemia

In a new pre-clinical study published this week in the journal Leukemia, the research team of Children's Hospital Los Angeles investigator Hisham Abdel-Azim, MD, MS, worked with colleagues to engineer T-cells to identify and target multiple sites on acute lymphoblastic leukemia cells instead of just one. The early collaboration points the way to future clinical trials to test the therapy.

1 Apr 2020

FDA to trial malaria drugs Chloroquine and Hydroxychloroquine for COVID-19

The U.S. Food and Drug Administration (FDA) this week provided the necessary authorization for clinical trials of chloroquine and hydroxychloroquine for the treatment of the novel coronavirus. These two drugs have been claimed by President Donald Trump to be a potential treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes COVID-19 disease. To date, there has been no conclusive proof regarding the safety and efficacy of these drugs in COVID-19 cases, say officials.

31 Mar 2020

Researchers discover new biomarker for early detection of Alzheimer's disease

Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer's disease.

31 Mar 2020

Mobile health devices effective in reducing AF-related adverse events, study finds

A new study, published in the Journal of the American College of Cardiology, highlights the feasible use of mobile health (mHealth) devices to help with the screening and detection of a common heart condition.

31 Mar 2020

Investigational oral form of treatment offers hope for adults with acromegaly

Adults who need medical maintenance treatment of the growth hormone disorder acromegaly respond well to an investigational oral form of the drug octreotide, investigators of the Chiasma OPTIMAL study reported.

31 Mar 2020

Cobra Biologics and Karolinska Institutet join forces to develop DNA vaccine against COVID-19

Cobra Biologics, an international CDMO for biologics and pharmaceuticals, and the Karolinska Institutet, one of the world’s leading medical universities, today announced they have been awarded €3 million emergency funding by Horizon 2020 for research and development, and phase I clinical trial testing of a DNA vaccine against COVID-19, as part of the OPENCORONA consortium to support global efforts tackling the pandemic.

31 Mar 2020

Fee app helps track onset and progression of COVID-19 symptoms in Americans

As the COVID-19 coronavirus pandemic grips the US, a new free app is helping to track the onset and progression of symptoms of millions across the nation. The app will help identify those at risk sooner, and help slow the outbreak of the disease.

31 Mar 2020

Vaping with counseling more effective than counseling alone for smoking cessation

Smokers who received smoking cessation counseling and used electronic cigarettes containing nicotine were more than twice as likely to successfully quit smoking compared to those who received counseling but did not use e-cigarettes, in a clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Clinical trial using genetic testing to guide antiplatelet therapy post-PCI falls short of stated goal

An international clinical trial that used genetic testing to guide which antiplatelet medication was given to patients following percutaneous coronary intervention (PCI) did not meet its stated goal for cutting in half the incidence of serious adverse cardiovascular events, such as heart attack and stroke, in the year following the procedure.

30 Mar 2020

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

The cholesterol drug alirocumab reduced low-density lipoprotein (LDL) cholesterol by 35.6% compared to placebo in adult patients with homozygous familial hypercholesterolemia (HoFH), according to a phase three clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Mount Sinai researchers figure out how to ramp up immune system to prevent tumor growth

Mount Sinai researchers have discovered a pathway that regulates special immune system cells in lung cancer tumors, suppressing them and allowing tumors to grow.

30 Mar 2020

Revita DMR therapy has potential to transform lives of patients with poorly controlled type 2 diabetes

Patients with poorly controlled type 2 diabetes who underwent a novel, minimally invasive, endoscopic procedure called Revita duodenal mucosal resurfacing had significantly improved blood glucose (sugar) levels, liver insulin sensitivity, and other metabolic measures three months later, according to new data from the REVITA-2 study.

30 Mar 2020

Experimental drug could offer new treatment for people with chronic heart failure

An experimental drug recently concluded a successful third-phase clinical trial and could potentially offer a new treatment for about 300,000 Canadians who have worsening chronic heart failure.

30 Mar 2020

UAB will collaborate with Altimmune to test a COVID-19 vaccine candidate

The University of Alabama at Birmingham is launching a collaboration with the biopharmaceutical company Altimmune, Inc. for preclinical testing of a potential vaccine to prevent COVID-19 disease.

30 Mar 2020

Will 'old faithful' tuberculosis BCG vaccine work against COVID?

All over the world, except in China, the place where it all began, the COVID-19 pandemic is making its relentless way through the population. So far, it has caused nearly 34,000 deaths – and the situation in the US is still worsening with over 142,000 cases and 2,489 deaths. In Australia, the number of cases has climbed to 4,093, with 16 fatalities.

29 Mar 2020

Clinical Trial News and Research

New collaboration may lead to future clinical trials to test treatment for leukemia

FDA to trial malaria drugs Chloroquine and Hydroxychloroquine for COVID-19

Researchers discover new biomarker for early detection of Alzheimer's disease

Mobile health devices effective in reducing AF-related adverse events, study finds

Investigational oral form of treatment offers hope for adults with acromegaly

Cobra Biologics and Karolinska Institutet join forces to develop DNA vaccine against COVID-19

Fee app helps track onset and progression of COVID-19 symptoms in Americans

Vaping with counseling more effective than counseling alone for smoking cessation

Clinical trial using genetic testing to guide antiplatelet therapy post-PCI falls short of stated goal

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

Mount Sinai researchers figure out how to ramp up immune system to prevent tumor growth

Revita DMR therapy has potential to transform lives of patients with poorly controlled type 2 diabetes

Experimental drug could offer new treatment for people with chronic heart failure

UAB will collaborate with Altimmune to test a COVID-19 vaccine candidate

Will 'old faithful' tuberculosis BCG vaccine work against COVID?

New in vivo priming strategy can be an effective means to enhance cardiac repair

Gene therapy investigators can greatly benefit from National Gene Vector Biorepository

UC Davis launches two clinical trials to evaluate treatments for COVID-19

Fast-acting anti-malarial compound shows promise in first clinical trial

Grifols Announces Formal Collaboration with US Government to Produce the First Treatment Specifically Targeting COVID-19

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