Cell Nucleus News and Research

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Scientists pinpoint new wake-promoting neurons in the brain

Scientists have identified an additional group of cells in the brain responsible for keeping us awake: the supramammillary nucleus, part of the caudal hypothalamus.

10 Nov 2017

Scientists uncover previously unknown mechanism to combat influenza A virus

Just as flu season swings into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus.

8 Nov 2017

Study: New histone modifications link cellular metabolism to chromatin architecture

Scientists of Helmholtz Zentrum München and Ludwig-Maximilians-Universität Munich (LMU) have discovered that two new classes of histone modifications couple cellular metabolism to gene activity. The study was published in 'Nature Structural and Molecular Biology'.

26 Oct 2017

Researchers discover mechanism that corrects protein misfolding in plants

Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's, Huntington's, and Parkinson's diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death.

25 Oct 2017

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological strategies that mitigate this defect.

17 Oct 2017

Specific regions of silenced DNA help define cell's identity, study suggests

The fundamental mechanisms governing how cells form an identity such as becoming a muscle cell or a nerve cell are not fully understood. Multiple diseases, including cancer, have been linked to cells going down the wrong developmental path during maturation.

13 Oct 2017

Researchers find potential approach to prevent peripheral neuropathy

In discovering how certain chemotherapy drugs cause the nerve damage known as peripheral neuropathy, researchers at Dana-Farber Cancer Institute have found a potential approach to preventing this common and troublesome side effect of cancer treatment.

11 Oct 2017

Mitochondrial DNA copy number appears to be predictive of sudden cardiac death, heart attacks

Johns Hopkins researchers report that the level, or "copy number," of mitochondrial DNA--genetic information stored not in a cell's nucleus but in the body's energy-creating mitochondria--is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen.

11 Oct 2017

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

9 Oct 2017

Study on cell stress response may hold promise for treating inflammation-related disorders

Stress – defined broadly – can have a profoundly deleterious effect on the human body. Even individual cells have their own way of dealing with environmental strains such as ultraviolet radiation from the sun or germs.

4 Oct 2017

Scientists unravel mechanism that links gut bacteria to hypertension

One in three American adults suffers from high blood pressure, or hypertension. The disease can be passed down in families, and certain lifestyle factors such as smoking, high-sodium diets, and stress can increase the risk.

3 Oct 2017

TSRI scientists developed new strategy to discover novel anti-cancer therapies

Scientists at The Scripps Research Institute (TSRI) have developed and demonstrated a promising new strategy for the discovery of novel anti-cancer therapies.

30 Sep 2017

Researcher discovers why people tend to fall asleep when bored

University of Tsukuba researcher discovers why we have the tendency to fall asleep in the absence of motivating stimuli, i.e., when bored.

30 Sep 2017

Biochemists discover genes that determine animal complexity

Genes which determine animal complexity – or what makes humans so much more complex than a fruit fly or a sea urchin – have been identified for the first time.

30 Sep 2017

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Osaka Researchers, in partnership with other Japanese and U.S. scientists, report a new gene target, KPNB1, for treatment against epithelial ovarian cancer (EOC).

28 Sep 2017

Scientists map brain circuitry underlying the drive to consume salt

While the average American's high-salt diet has been linked to high blood pressure and cardiovascular disease, the truth is we couldn't live without this once scarce mineral.

27 Sep 2017

Long-lasting effects of traumatic childhood experiences may be due to impaired neural connections

Researchers from the McGill Group for Suicide Studies, based at the Douglas Mental Health University Institute and McGill University’s Department of Psychiatry, have just published research in the American Journal of Psychiatry that suggests that the long-lasting effects of traumatic childhood experiences, like severe abuse, may be due to an impaired structure and functioning of cells in the anterior cingulate cortex.

25 Sep 2017

MIT engineers design more effective synthetic mRNA delivery system

By delivering strands of genetic material known as messenger RNA into cells, researchers can induce the cells to produce any protein encoded by the mRNA. This technique holds great potential for administering vaccines or treating diseases such as cancer, but achieving efficient delivery of mRNA has proven challenging.

21 Sep 2017

Oxytocin promotes avoidance of unfamiliar situations after negative social interactions

Before you shop for the "cuddle" hormone oxytocin to relieve stress and enhance your social life, read this: a new study from the University of California, Davis, suggests that sometimes, blocking the action of oxytocin in the brain may be a better option.

20 Sep 2017

Analytical Science in Precision Medicine

Pittcon is an analytical conference, so naturally my talk will be about analytical chemistry and how analytical chemistry will become increasingly important in delivering healthcare solutions, not only for rich people, but also, hopefully, for poor people across the world.

From Pittcon 19 Sep 2017

Cell Nucleus News and Research

Scientists pinpoint new wake-promoting neurons in the brain

Scientists uncover previously unknown mechanism to combat influenza A virus

Study: New histone modifications link cellular metabolism to chromatin architecture

Researchers discover mechanism that corrects protein misfolding in plants

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

Specific regions of silenced DNA help define cell's identity, study suggests

Researchers find potential approach to prevent peripheral neuropathy

Mitochondrial DNA copy number appears to be predictive of sudden cardiac death, heart attacks

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Study on cell stress response may hold promise for treating inflammation-related disorders

Scientists unravel mechanism that links gut bacteria to hypertension

TSRI scientists developed new strategy to discover novel anti-cancer therapies

Researcher discovers why people tend to fall asleep when bored

Biochemists discover genes that determine animal complexity

Drug approved to treat parasitic infections also exerts anti-tumor effect on EOC cells

Scientists map brain circuitry underlying the drive to consume salt

Long-lasting effects of traumatic childhood experiences may be due to impaired neural connections

MIT engineers design more effective synthetic mRNA delivery system

Oxytocin promotes avoidance of unfamiliar situations after negative social interactions

Analytical Science in Precision Medicine

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