DNA Sequencing News and Research

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DNA sequence variation can influence gene activity in developing human brain

An international research collaboration has shed new light on how DNA sequence variation can influence gene activity in the developing human brain.

1 Dec 2015

Research sheds light on genetic factors involved in autoimmune diseases

A collaboration between researchers at the Babraham Institute and the University of Manchester has mapped the physical connections occurring in the genome to shed light on the parts of the genome involved in autoimmune diseases. Using a new technique, called Capture Hi-C, the team revealed novel insights into how changes in the genetic sequence have a biological effect and increase the risk of disease.

30 Nov 2015

Scientists map out genes that keep cancer cells alive

Scientists have mapped out the genes that keep our cells alive, creating a long-awaited foothold for understanding how our genome works and which genes are crucial in disease like cancer.

26 Nov 2015

Researchers aiming to improve accuracy of current diagnostics for Leishmania infantum kinetoplast

In an article published in Small, researchers successfully applied a new qualitative and quantitative method for the detection of a DNA sequence characteristic of Leishmania infantum kinetoplast, a frequent parasite in veterinary that affects humans too.

26 Nov 2015

Research brings scientists closer to understanding mechanisms underlying genomic imprinting process

Research led by Dr. Keiji Tanimoto from the University of Tsukuba, Japan, has brought us closer to understanding the mechanisms underlying the phenomenon of genomic imprinting.

25 Nov 2015

Prenatal smoking exposure can potentially affect someone's health for years after birth

New Johns Hopkins Bloomberg School of Public Health-led research finds that blood taken from children up to the age of five contains molecular evidence about whether their mothers smoked during pregnancy.

23 Nov 2015

CRISPR tool unlocks potential for novel treatments across different therapeutic areas

CRISPR is one of the most exciting advances in gene-based medicine in decades. A uniquely powerful tool for editing the genome, it allows scientists to manipulate DNA with unprecedented precision by deleting unwanted or faulty genes and replacing them with different ones. Its promise in this field of medicine is immense, unlocking the potential for novel treatments across a wide range of therapeutic areas.

22 Nov 2015

Role of genetic predisposition in pediatric cancer patients

The most detailed analysis yet of the role germline mutations in genes associated with cancer predisposition play in the development of childhood cancer suggests that comprehensive genomic screening may be warranted on all pediatric cancer patients, not just those with a family history of cancer.

19 Nov 2015

IMB scientists unravel complex regulatory mechanism involved in brain development

Scientists at the Institute of Molecular Biology in Mainz have unraveled a complex regulatory mechanism that explains how a single gene can drive the formation of brain cells. The research, published in The EMBO Journal, is an important step towards a better understanding of how the brain develops. It also harbors potential for regenerative medicine.

19 Nov 2015

MedUni Vienna researchers discover genetic cause of a rare disease

Researchers at MedUni Vienna have discovered the genetic cause of a rare disease characterized by life-threatening "liver crises" in early childhood and subsequent manifestation of neurological symptoms, such as neuropathy and ataxia (a movement disorder), when they reach school age.

15 Nov 2015

Crucial change in single DNA base predisposes children to aggressive form of cancer

Pediatric oncology researchers have pinpointed a crucial change in a single DNA base that both predisposes children to an aggressive form of the childhood cancer neuroblastoma and makes the disease progress once tumors form.

12 Nov 2015

New method may extend use of noninvasive prenatal testing to detect chromosomal abnormalities

Researchers at the University of California, San Diego School of Medicine developed a method to expand the types of chromosomal abnormalities that noninvasive prenatal testing (NIPT) can detect. The study, published November 9 by Proceedings of the National Academy of Sciences, uses a semiconductor sequencing platform to identify small chromosomal deletions or duplications, such as occur in Cri du Chat Syndrome and DiGeorge Syndrome, with a simple blood test from the expectant mother.

10 Nov 2015

Utah chemists devise new way to detect DNA damage

University of Utah chemists devised a new way to detect chemical damage to DNA that sometimes leads to genetic mutations responsible for many diseases, including various cancers and neurological disorders.

6 Nov 2015

Researchers develop multiplexed screening approach to study cancer development in mice

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their cancer-causing roles and determining which combinations of genes cooperate to cause liver cancer.

27 Oct 2015

UW researchers develop new model to more accurately predict harmful genetic mutations

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA.

26 Oct 2015

Researchers develop new method to predict people's biological age

New research has shed light on the molecular changes that occur in our bodies as we age. In the largest study of its kind, an international group of researchers, including experts from the University of Exeter's Medical School, examined expression of genes in blood samples from 15,000 people across the world.

26 Oct 2015

Juneau Biosciences presents new genetic discoveries in endometriosis at annual ASRM meeting

This week, Juneau Biosciences, LLC presented new discoveries concerning the genetics of endometriosis at the annual American Society of Reproductive Medicine (ASRM) meeting in Baltimore, MD.

23 Oct 2015

Genetic mutation linked to ALS, FTD prevents proteins from entering and exiting the cell's nucleus

Three teams of scientists supported by the National Institutes of Health showed that a genetic mutation linked to some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) may destroy neurons by disrupting the movement of materials in and out of the cell's nucleus, or command center where most of its DNA is stored.

19 Oct 2015

New UCL study highlights genes associated with schizophrenia and obesity

Genes involved in schizophrenia and obesity have been highlighted in a new UCL study, which could lead to a better understanding of the DNA variants which affect risk of these conditions and aid the development of improved strategies for prevention and treatment.

18 Oct 2015

International consortium provides standard protocol for using Oxford Nanopore's DNA-sequencing device

The MinION, a handheld DNA-sequencing device developed by Oxford Nanopore, has been tested and evaluated by an independent, international consortium coordinated by EMBL's European Bioinformatics Institute (EMBL-EBI).

16 Oct 2015