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Alveolar macrophages present as antigens to promote virus-specific CD8+ T cell expansion

The human immune system is a highly complex network of cells, signals, and responses that is tightly regulated to ensure that the body can fight off infection without damaging its own tissues.

28 Dec 2022

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNASEL) noted in coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory syndrome in children (MIS-C).

23 Dec 2022

Using the gut microbiome to understand and treat respiratory diseases

Researchers review the role of the gut microbiome in certain respiratory diseases.

22 Dec 2022

What are the long-term outcomes of critical COVID-19 patients?

Researchers assessed the long-term outcomes of critically ill coronavirus disease 2019 (COVID-19) patients.

21 Dec 2022

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

A new study discussed the findings of Chai et al., which revealed that triple specificity protein phosphatase (ptpB) secreted by Mycobacterium tuberculosis inhibits pyroptosis and the release of cytokines by macrophages, allowing M. tuberculosis to invade the immune system.

19 Dec 2022

Scientists make breakthrough in understanding how inflammation is regulated

Scientists from Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the opposite.

16 Dec 2022

Using synthetic gene circuits to better control the timing of immunotherapy

In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales.

16 Dec 2022

Correlating circulating adipokine levels with COVID-19 severity

Researchers determine whether plasma adipokine levels were associated with COVID-19-related systemic inflammation and severity.

14 Dec 2022

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

In a recent study posted to bioRxiv*, researchers in the United States assessed the impact of metabolic diseases on coronavirus disease 2019 (COVID-19) vaccine immunogenicity in a mouse model.

13 Dec 2022

Globally, COVID-19 mortality biomarkers have varied efficacy

Some of the biomarkers used to predict mortality due to COVID-19 show variable efficacies in different parts of the world;

13 Dec 2022

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Researchers assessed the association of enhanced migratory or activated CD8+ T cell and reduced avidity reactive cellular response due to post-acute COVID-19 syndrome (PASC).

13 Dec 2022

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

Researchers from the University of Pennsylvania's Abramson Cancer Center presented preliminary results of an ongoing Phase I clinical trial demonstrating successful re-treatment with CAR T cell therapy for patients whose cancers relapsed after previous CAR T therapy at the 2022 American Society of Hematology Annual Meeting.

12 Dec 2022

UH researchers investigate how traumatic experiences affect mental and physical health of migrants

In a first of its kind study, University of Houston psychology researchers are investigating how the trauma experienced by migrants before and during the journey to the United States affects their mental and physical health.

8 Dec 2022

Estrogen replacement therapy may be a tool to mitigate delirium

Delirium is common among women with urinary tract infections (UTIs) - especially those who have experienced menopause.

8 Dec 2022

What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19?

In a new study, researchers observed that coronavirus disease 2019 (COVID-19) progression and inflammatory responses are associated with changes in the metabolome and microbiome.

8 Dec 2022

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Researchers investigated the immunological mechanisms behind the decreasing efficacy of COVID-19 vaccines by evaluating the durability and magnitude of neutralizing antibodies and memory B and T cell responses to booster doses of mRNA COVID-19 vaccine.

8 Dec 2022

Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial

Researchers reported the immunogenicity, efficacy, and safety of the MVA-BN (modified vaccinia Ankara-Bavarian Nordic)-RSV (respiratory syncytial virus) vaccine against RSV-A (RSV subtype A) Memphis 37b strain in a human challenge trial.

7 Dec 2022

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Researchers investigated the clinical, histopathological, imaging, and serological characteristics of post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in patients with mild COVID-19.

5 Dec 2022

Study provides understanding of SARS-CoV-2 pulmonary infection long-term effects at the microanatomical, cellular, and molecular level

Researchers evaluated compositional and structural pulmonary alterations in PASC tissues.

5 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022

Interleukin 5 News and Research

Alveolar macrophages present as antigens to promote virus-specific CD8+ T cell expansion

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Using the gut microbiome to understand and treat respiratory diseases

What are the long-term outcomes of critical COVID-19 patients?

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

Scientists make breakthrough in understanding how inflammation is regulated

Using synthetic gene circuits to better control the timing of immunotherapy

Correlating circulating adipokine levels with COVID-19 severity

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

Globally, COVID-19 mortality biomarkers have varied efficacy

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

UH researchers investigate how traumatic experiences affect mental and physical health of migrants

Estrogen replacement therapy may be a tool to mitigate delirium

What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19?

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Study provides understanding of SARS-CoV-2 pulmonary infection long-term effects at the microanatomical, cellular, and molecular level

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

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