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New low-cost artificial mitral valve mimics human tissue to study disease

Researchers at RCSI University of Medicine and Health Sciences have developed an artificial model of the mitral heart valve that faithfully mimics the valve's complex mechanical behavior in the human heart.

11 Jun 2026

A hidden immune pathway may help explain why Alzheimer’s inflammation persists

Researchers found that KAT7 promotes CMPK2-driven mitochondrial DNA release in microglia, activating inflammatory cGAS-STING and NLRP3 pathways linked to Alzheimer’s disease.

11 Jun 2026

Western diet weakens the gut’s nervous system through iron-dependent damage

A JCI study found that exposure to a Western diet in mice and to palmitic acid in murine and ex vivo human enteric nervous system models triggered ferroptosis, characterized by iron loading, lipid peroxidation, mitochondrial stress, and enteric neuronal loss. Boosting Nrf2 signaling protected enteric neurons and prevented Western diet-induced delayed colonic transit in mice, pointing to a potential pathway linking dietary fat exposure to gut motility dysfunction.

10 Jun 2026

Researchers identify genetic cause of severe childhood lung disease

A new report in the American Journal of Human Genetics describes a novel disorder caused by biallelic loss-of-function variants in the TMEM63B gene, which results in severe lung disease.

10 Jun 2026

Key proteins enable louse-borne relapsing fever pathogen to evade immunity

Louse-borne relapsing fever is caused by the spirochete bacterium Borrelia recurrentis, which is transmitted by body lice (not head lice).

10 Jun 2026

Study identifies an important driver of inflammatory bowel disease

Researchers at the Nuffield Department of Medicine, University of Oxford, together with Newcastle University's Translational and Clinical Research Institute and the Department of Immunology at Cambridge University Hospitals NHS Foundation Trust, have identified an important driver of inflammatory bowel disease (IBD).

10 Jun 2026

New DNA tetrahedron nanostructures improve targeted cancer therapy delivery

Conventional cancer treatments, such as chemotherapy, often lack specificity and can damage both cancerous and healthy cells, leading to severe side effects.

10 Jun 2026

Automated self-driving labs accelerate the search for new medicines

The Acceleration Consortium (AC) at the University of Toronto and the Structural Genomics Consortium (SGC) announced today a formalized partnership to help tackle a persistent challenge in biomedicine and early drug discovery: the development of bioactive molecules with drug-like properties, advancing our understanding of human health and disease and jump-starting new drug discovery programs.

10 Jun 2026

New meningioma atlas uncovers clues to tumor aggressiveness

One of the most detailed maps to date of meningioma - the most common brain tumor in adults - reveals how the tumor's surrounding environment helps drive disease behavior and patient outcomes, according to new research from Mayo Clinic.

9 Jun 2026

NHS pathology staff face unsafe formaldehyde exposure levels

Routine exposure to harmful levels of the human tissue preservative formaldehyde are risking the health of thousands of NHS staff working in pathology departments across the UK, due to poor monitoring and control, finds an analysis of Freedom of Information (FOI) requests, published online in the journal Occupational & Environmental Medicine.

9 Jun 2026

Apitegromab helps tirzepatide users lose fat while preserving lean mass

A phase 2 trial found that apitegromab plus tirzepatide reduced lean body mass loss by 1.9 kg compared with tirzepatide plus placebo after 24 weeks, while overall weight loss remained similar.

9 Jun 2026

Machine learning model filters out the biological noise in liquid biopsy samples

A machine learning model developed by researchers at the Johns Hopkins Kimmel Cancer Center filters out the biological noise in liquid biopsy samples, helping clinicians better match therapies to their patients' tumors.

9 Jun 2026

New digital platform treats insomnia and anxiety in seniors

Cognitive behavioral therapies for insomnia (CBT-I) are increasingly being delivered online in order to improve accessibility.

9 Jun 2026

New study frames altered protein modifications as cancer drivers

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

9 Jun 2026

Japanese study reveals how healthcare systems shape immigration preferences

In recent years, anti-immigration sentiment has become increasingly common around the world. A common concern surrounding immigration is its potential impact on the host country's welfare system, including healthcare.

9 Jun 2026

Realistic cellular conditions revive previously dismissed drug candidates

A drug once dismissed as ineffective suddenly worked - when scientists tested it under more realistic conditions that mimic the human body.

9 Jun 2026

Active β-catenin promotes aggressive spread of childhood bone cancer

A new research paper was recently published in Volume 17 of Genes & Cancer, titled "Active Beta-Catenin (ABC) promotes an invasive phenotype in pediatric osteosarcoma."

9 Jun 2026

Experimental two‑in‑one vaccine shows success in human LASSARAB trial

Researchers from Thomas Jefferson University and the University of Maryland School of Medicine have reported encouraging results from the first human clinical trial of LASSARAB, an experimental vaccine designed to protect against Lassa fever and rabies in a single formulation.

9 Jun 2026

Immune cell defects may drive celiac disease development

New research from the Snow Centre for Immune Health is challenging long-held assumptions about autoimmune disease, revealing that coeliac disease may be driven not just by an overactive immune system, but by subtle defects in how immune cells function.

9 Jun 2026

Frailty flags poorer blood pressure control in older women

In 1,038 older adults with hypertension attending outpatient clinics in Vietnam, frailty was more common in women than men, while overall rates of suboptimal blood pressure were similar by sex. Frailty was associated with about twice the odds of suboptimal blood pressure in women, but not in men, highlighting the need to study sex-specific and frailty-informed hypertension care.

8 Jun 2026