Biochemistry News and Research

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Protein called CPSF73 performs a necessary step in the production of human chromosomes

The study found that a protein called CPSF73 acts like scissors to cut strands of histone messenger RNA (mRNA) in the cell nucleus. This cutting action produces the mRNA needed to create histone proteins that combine with DNA to form chromosomes.

12 Oct 2005

Quest to develop synthetic versions of rare natural substances to cure tobacco-related diseases

Within a laboratory on the Florida State University campus, a chemist leads a team of researchers in a quest to develop synthetic versions of rare natural substances. If all goes well, the team’s efforts could pay off in the form of the next generation of cancer-fighting drugs.

12 Oct 2005

Researchers reveal basis for hereditary coproporphyria

A research team led by scientists at The University of Texas Medical School at Houston has determined the structure of an enzyme that when defective causes an inherited disease that afflicts sufferers with severe abdominal pain, psychiatric symptoms, skin fragility, and light sensitivity.

9 Oct 2005

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

4 Oct 2005

Researchers have successfully combined computer modeling and experimental results in folding studies for small proteins

In unprecedented new research, scientists at Rice University have combined theory and experiment for the first time to both predict theoretically and verify experimentally the protein-folding dynamics of a large, complex protein.

3 Oct 2005

Scientists measure with unprecedented accuracy the strengths of hydrogen bonds in a protein

The scientists were then able to predict the function of different versions of the protein based on structural information, a novel outcome that was published recently in the Proceedings of the National Academy of Sciences.

3 Oct 2005

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

3 Oct 2005

Dengue and other viruses may have developed tricks that let them reproduce inside macrophages

A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point.

28 Sep 2005

New Stat1 and interferon findings

By altering a molecule called Stat1, which is involved in cellular immune signaling, scientists have succeeded in making the molecule more responsive and thus more efficient. This old protein with a new twist may eventually be used to improve the body's defense against infection.

28 Sep 2005

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer.

27 Sep 2005

Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.

26 Sep 2005

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Their findings, which may point to new approaches to developing improved treatment options for the disease, are published in the journal Nature.

26 Sep 2005

Potential oral drug for rheumatoid arthritis

A potential oral drug for rheumatoid arthritis (RA) may encourage women to treat their condition earlier rather than later because it is less arduous than currently available treatments. Early treatment is important because RA most often develops between the ages of 35 and 50 and is two- to three times more prevalent in women.

26 Sep 2005

New way to create a permanent chemical bond between antibiotics and titanium

Infections associated with inserting a medical device can be devastating, painful, and cause prolonged disability, costing tens of thousands of dollars.

26 Sep 2005

Set of simple "rules" that nature appears to use to design proteins

By examining how proteins have evolved, UT Southwestern Medical Center researchers have discovered a set of simple "rules" that nature appears to use to design proteins, rules the scientists have now employed to create artificial proteins that look and function just like their natural counterparts.

26 Sep 2005

Possible molecular origin of at least nine human diseases of nervous system degeneration

These neurodegenerative diseases, including Huntington's disease, share an abnormal deposit of proteins inside nerve cells. This deposition of protein results from a kind of genetic stutter within the cell's nucleus asking for multiple copies of the amino acid glutamine, a building block of protein structure.

26 Sep 2005

Study clarifies insulin's role in blocking release of energy in patients with type II diabetes

Chronically high levels of insulin, as is found in many people with obesity and Type II diabetes, may block specific hormones that trigger energy release into the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine.

22 Sep 2005

Biochemistry News and Research

Protein called CPSF73 performs a necessary step in the production of human chromosomes

Quest to develop synthetic versions of rare natural substances to cure tobacco-related diseases

Researchers reveal basis for hereditary coproporphyria

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

Researchers have successfully combined computer modeling and experimental results in folding studies for small proteins

Scientists measure with unprecedented accuracy the strengths of hydrogen bonds in a protein

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

Dengue and other viruses may have developed tricks that let them reproduce inside macrophages

New Stat1 and interferon findings

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

Chronically high levels of insulin may block specific hormones that trigger energy release into the body

Potential oral drug for rheumatoid arthritis

New way to create a permanent chemical bond between antibiotics and titanium

Set of simple "rules" that nature appears to use to design proteins

Possible molecular origin of at least nine human diseases of nervous system degeneration

Study clarifies insulin's role in blocking release of energy in patients with type II diabetes

Simple organism can produce 10 trillion varieties of a single protein

Prions rapidly 'remodel' good protein into bad

Diabetics with fatty livers could benefit from diet rich in soy protein

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