Biochemistry News and Research

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Researchers characterize the proteome of the human cornea

In doing so, they have identified 141 distinct proteins, 99 of which had not been previously recognized in mammalian corneas. The details of their findings appear in the August/September issue of Molecular and Cellular Proteomics, an American Society for Biochemistry and Molecular Biology journal.

1 Aug 2005

Controlling the expression of genes by turning them on or off could produce a drug for the treatment or cure of almost any disease

A new technique aimed at directly controlling the expression of genes by turning them on or off at the DNA level could lead to drugs for the treatment or cure of many diseases, say researchers at UT Southwestern Medical Center.

1 Aug 2005

Researchers make headway in mystery of migraines

The research, published in the new issue of the Proceedings of National Academy of Sciences (PNAS), reveals how gene mutations known to cause a form of inherited migraine target a cellular process involved in brain cell communication.

27 Jul 2005

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Finding biological markers that flag aneurysm, a bulging of the aorta that leads to dissection, a lengthwise separation of tissues in the artery wall, is critically important for early diagnosis.

25 Jul 2005

Project to help millions of people avoid starvation

Scientists at the University of Bath will be taking part in an international £4.2 million ($7.5 million) research project that could help millions of people avoid starvation.

21 Jul 2005

Researchers have doubled the potency of a protein that drives blood to clot

...according to research to be published in the July 26 edition of Biochemistry. The study results may have profound implications for the treatment of hemophilia, the inherited blood disorder that causes easy or excessive bleeding in 30,000 Americans.

20 Jul 2005

Study provides evidence that hormone treatments can be beneficial to limiting cardiovascular ailments

UC Irvine School of Medicine researchers have identified how estrogen helps prevents a cardiac ailment often seen in women who have heart attacks. This research provides further evidence that hormone replacement therapy after menopause can help prevent certain forms of cardiovascular disease in women.

19 Jul 2005

Scientists determine the structures of eight proteins in just 10-20 days per protein

A University at Buffalo scientist created a stir in 2003 when he announced a much faster, more precise and far less expensive method of obtaining nuclear magnetic resonance (NMR) data to map a protein's atomic structure. Genomics researchers were fascinated, but some also were a bit skeptical.

18 Jul 2005

Lipid helps cell wall protein fold into proper shape

A protein that provides a vital passage through a bacterium's outer cell wall will misfold and malfunction if that wall is built of the 'wrong' material, scientists at The University of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases caused by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease.

17 Jul 2005

X-ray crystallography images show how a protein called alpha-actinin performs molecular ballet

As a cell moves forward, physical stress on its skeleton triggers molecular fingers and arms to grasp each other in reinforcing links that stabilize the skeleton, according to images produced by investigators at St. Jude Children's Research Hospital.

12 Jul 2005

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents through a cellular stress response that activates a pro-survival protein called GRP78, according to researchers from the Keck School of Medicine of the University of Southern California.

6 Jul 2005

Researchers find enzyme vital for controlling the early stages of cell death

Researchers at UT Southwestern Medical Center have found an enzyme vital for controlling the early stages of cell death - a beneficial and normal process when it works right, but malignant in a variety of cancers when it malfunctions.

30 Jun 2005

Old skin fungus drug has been found to be a possible cancer treatment

A drug that has been used for 40 years for the treatment of skin fungus has been found to be a possible cancer treatment, according to an international team of scientists. Leslie Wilson, professor of biochemistry and pharmacology at the University of California, Santa Barbara, said that the antifungal drug, griseofulvin, has been shown to inhibit the growth of cancer cells in his laboratory.

30 Jun 2005

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

In a ground-breaking study, scientists at Children's Hospital of Pittsburgh have discovered that adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply, a previously unknown characteristic indicating that post-natal stem cells may play an important therapeutic role.

27 Jun 2005

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

27 Jun 2005

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

In the fifty-year history since the structure of DNA was first revealed, what was once a Nobel prize- winning research discovery has become an omnipresent cultural icon co-opted for promoting everything from fragrances to musical acts.

20 Jun 2005

Holographic movies show promise for medical applications

In a small research laboratory at UT Southwestern Medical Center, a grainy, red movie of circling fighter jets emerges from a table-top black box, while nearby, a video of a rotating human heart hangs suspended in a tank of gooey gel.

14 Jun 2005

Tetanus toxin may help fight depression, anxiety, anorexia and Parkinson's

A team of researchers from the Department of Biochemistry and Molecular Biology and the Institute of Neuroscience at the Universitat Autònoma de Barcelona has discovered that tetanus toxin, which causes tetanus, could be extremely useful as a therapy against psychological disorders such as depression, anxiety and anorexia, and to slow the progress of neurodegenerative disorders such as Parkinson's disease.

14 Jun 2005

Venom of marine cone snails may provide an improved treatment for neuropathic pain associated with diabetes

A cone snail toxin discovered by Melbourne researchers has proven to have great potential for easing pain and could provide an improved treatment for neuropathic pain associated with diabetes.

12 Jun 2005

First clues as to why stem cells ignore stop signs in the cell cycle

Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing.

10 Jun 2005

Biochemistry News and Research

Researchers characterize the proteome of the human cornea

Controlling the expression of genes by turning them on or off could produce a drug for the treatment or cure of almost any disease

Researchers make headway in mystery of migraines

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Project to help millions of people avoid starvation

Researchers have doubled the potency of a protein that drives blood to clot

Study provides evidence that hormone treatments can be beneficial to limiting cardiovascular ailments

Scientists determine the structures of eight proteins in just 10-20 days per protein

Lipid helps cell wall protein fold into proper shape

X-ray crystallography images show how a protein called alpha-actinin performs molecular ballet

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents

Researchers find enzyme vital for controlling the early stages of cell death

Old skin fungus drug has been found to be a possible cancer treatment

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

Holographic movies show promise for medical applications

Tetanus toxin may help fight depression, anxiety, anorexia and Parkinson's

Venom of marine cone snails may provide an improved treatment for neuropathic pain associated with diabetes

First clues as to why stem cells ignore stop signs in the cell cycle

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