Biochemistry News and Research

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Researchers explain how ubiquitin function is determined

University of Maryland researchers have explained, for the first time, why the linkage between the cell-regulating protein molecules called ubiquitins determines their function.

10 Jun 2005

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

An international team of chemists and molecular biologists has discovered a fundamental molecular mechanism that seems to play an important role in Alzheimer's disease, Parkinson's disease, mad cow disease and two-dozen other degenerative and fatal diseases.

8 Jun 2005

New device has the potential to significantly reduce sequencing of the human genome

The sequencing of the human genome was only the beginning of a much more complex task – deciphering the secrets of cellular chemistry and the mechanisms of disease. While the genome serves as a blueprint to understanding the body, proteins represent the materials that carry out these plans.

8 Jun 2005

Detox diets unsound science and do not work

Scientists say there is no proof that Detox diets work and they do no more to rid the body of toxins than the body's own natural system.

8 Jun 2005

Gene therapy for arthritis is both feasible and safe

Gene therapy for arthritis and other non-terminal, debilitating conditions and diseases is both feasible and safe, report researchers who conducted the world's first such test on the approach in patients with advanced rheumatoid arthritis.

6 Jun 2005

Research explains why Shigella and E. coli are rapidly becoming resistant to fluoroquinolones

Scientists at the Albert Einstein College of Medicine have discovered a novel strategy by which the bacterium that causes tuberculosis may soon be able to resist the effects of antibiotics known as fluoroquinolones.

3 Jun 2005

The bacteria that cause food poisoning, bubonic plague, and whooping cough all deploy the same weapon to infect the body

A molecular "syringe" sticks out of the bacteria, pokes a hole in a nearby cell, and squirts in venomous proteins that hijack the cell's machinery.

2 Jun 2005

Scientists shed new light on how protein Ro creates RNA quality control system for cells

A report by Yale scientists in the journal Cell sheds new light on how the protein Ro, a major autoantigen in patients with autoimmune disease, recognizes misfolded RNAs, creating a RNA quality control system for cells.

1 Jun 2005

Flavonols in food, key to healthy eating?

University of Melbourne scientists may have found the secret of the fresh fruit and vegetables centred ‘Mediterranean diet’.

29 May 2005

Discovery may lead to therapies to treat the neurological disease

Opening a window to understand the molecular basis of a hereditary ataxia, Dartmouth Medical School researchers have identified an enzyme activity that is inactivated in all reported mutant forms of a disease protein. The discovery may lead to therapies to treat the neurological disease.

29 May 2005

Brain fatty acid levels linked to depression

A group of researchers from Israel has discovered that rats exhibiting the signs of depression have increased levels of the omega-6 fatty acid, arachidonic acid, in their brains. The details of their findings appear in the June issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

25 May 2005

New polysaccharide may help combat multidrug resistance in cancer

In a recent study published in the Journal of Biological Chemistry, scientists report that a molecule previously thought to play a purely structural and inert role in cells is actually involved in multidrug resistance in cancer.

22 May 2005

Drugs that block the enzyme Odc prevent the onset of cancers

The drug DFMO prevents cancer in laboratory models of lymphoma but fails to kill existing cancerous cells that have lost the ability to self-destruct, according to investigators at St. Jude Children's Research Hospital.

16 May 2005

More health benefits from green tea

Green tea appears to protect against cancer by affecting a "promiscuous" protein that pharmaceutical experts are already targeting in an effort to develop a new drug to stop the disease, scientists at the University of Rochester Medical Center have found.

16 May 2005

Clues about how alcoholic behavior is “switched” on

As part of an ongoing effort to understand the biochemical basis of alcohol abuse, scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have published two studies on how modulating receptors for dopamine - a chemical “signaler” in the brain’s reward circuits - affects drinking behavior in mice and rats.

9 May 2005

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

By deciphering the ingenious mechanism used by a particular enzyme to modify bacterial chromosome chemistry, scientists have come a step closer to designing a new kind of drug that could stop virulent bacterial infections in their tracks. Their research will be published in the May 6 issue of the journal Cell.

5 May 2005

Two-photon imaging gives real-time video of cells in living tissue

Biologists have a new tool to track and videotape cells moving about inside living tissue.

3 May 2005

Researchers make new advances in determining the structure of all possible DNA sequences

Oregon State University researchers have made significant new advances in determining the structure of all possible DNA sequences – a discovery that in one sense takes up where Watson and Crick left off, after outlining in 1953 the double-helical structure of this biological blueprint for life.

3 May 2005

Food fried in vegetable oil contains a highly toxic compound - HNE (4-hydroxy-trans-2-nonenal)

University of Minnesota researchers A. Saari Csallany, a professor of food chemistry and nutritional biochemistry, and graduate student Christine Seppanen have shown that when highly unsaturated vegetable oils are heated at frying temperature (365 F) for extended periods--or even for half an hour--a highly toxic compound, HNE (4-hydroxy-trans-2-nonenal) forms in the oil.

2 May 2005

Researchers determine mechanism of action of chemotherapy drug motexafin gadolinium

The chemotherapy drug motexafin gadolinium (brand name: Xcytrin, manufactured by Pharmacyclics, Inc.) works to thwart cancer cells by disrupting key enzymes involved in cellular metabolism, according to a team of researchers led by Joseph Hacia, Ph.D., assistant professor of biochemistry and molecular biology at the Keck School of Medicine of the University of Southern California.

1 May 2005

Biochemistry News and Research

Researchers explain how ubiquitin function is determined

Discovery of molecular mechanism that seems to play an important role in Alzheimer's disease

New device has the potential to significantly reduce sequencing of the human genome

Detox diets unsound science and do not work

Gene therapy for arthritis is both feasible and safe

Research explains why Shigella and E. coli are rapidly becoming resistant to fluoroquinolones

The bacteria that cause food poisoning, bubonic plague, and whooping cough all deploy the same weapon to infect the body

Scientists shed new light on how protein Ro creates RNA quality control system for cells

Flavonols in food, key to healthy eating?

Discovery may lead to therapies to treat the neurological disease

Brain fatty acid levels linked to depression

New polysaccharide may help combat multidrug resistance in cancer

Drugs that block the enzyme Odc prevent the onset of cancers

More health benefits from green tea

Clues about how alcoholic behavior is “switched” on

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

Two-photon imaging gives real-time video of cells in living tissue

Researchers make new advances in determining the structure of all possible DNA sequences

Food fried in vegetable oil contains a highly toxic compound - HNE (4-hydroxy-trans-2-nonenal)

Researchers determine mechanism of action of chemotherapy drug motexafin gadolinium

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