Clinical Trial News and Research

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Moffitt research may provide a path toward improved multi-drug adaptive therapies

Personalized cancer treatments have greatly improved the lives of patients; however, many eventually develop resistance to these targeted drugs.

13 Feb 2020

Understanding stress-induced bladder dysfunction in children

We know that stress can have a profound impact on health. But it's rare to discover a health issue that is caused directly by stress.

13 Feb 2020

Nurse creates a self-management tool for patients with left ventricular assist device

In the early 90s, Dr. Jessie Casida was one of few nurses working on the first patient with a left ventricular assist device - a battery-powered device that pumps blood, surgically implanted into the heart of patients who have end-stage heart failure.

13 Feb 2020

To fight Chinese outbreak, doctors deploy drugs targeting HIV, malaria and Ebola

As the scientific community scrambles to find a drug that can effectively treat tens of thousands of patients sickened by a new respiratory virus, they are trying some surprising remedies: medicines targeting known killers like HIV, Ebola and malaria.

13 Feb 2020

Combination of two antibiotics found to be no better than one for treating MRSA blood infections

Researchers attempting to improve the treatment for methicillin-resistant Staphylococcus aureus (MRSA) blood infections have discovered the combination of two antibiotics was no better than one, and led to more adverse effects.

11 Feb 2020

New study confirms link between type 2 diabetes drug and increased risk of heart problems

A new study published by The BMJ adds to evidence that rosiglitazone - a drug used to treat type 2 diabetes - is associated with increased risk of heart problems, especially heart failure.

11 Feb 2020

Study evaluates feasibility of using T'ai Chi to improve chronic low back pain in older adults

A new study evaluated the feasibility and acceptability of using T'ai Chi to improve chronic low back pain in adults over 65 years of age compared to health education and usual care.

11 Feb 2020

Braincool completes patient recruitment to study Cooral System for prevention of Oral Mucositis

BrainCool AB, a Swedish medical device innovator, and a world leader in medical cooling technology for therapeutic hypothermia (brain cooling) and oncology, is pleased to announce that it has completed patient recruitment in the Scandinavian multi-center pivotal trial of 180 patients to investigate the patented Cooral® System for prevention of Oral Mucositis, one of the most debilitating side-effects of both standard and high-dose chemotherapeutic oncology treatments.

11 Feb 2020

Depression treatment using AI, brain scans

Artificial intelligence (AI) may be a useful and even essential tool in selecting the best treatment for depression, according to a new study published in the journal Nature Biotechnology on February 2020.

10 Feb 2020

New summary report highlights advances and challenges in small cell lung cancer research

In 2017, a group of lung cancer experts posed the question: "Can recent advances in tumor biology that have led to progress treating non-small cell lung cancer translate into improved outcomes for small cell lung cancer?"

10 Feb 2020

New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

The first clinical trial specifically designed to test the safety of the monthly dapivirine vaginal ring in pregnant women has begun in southern and eastern Africa.

10 Feb 2020

Statin use alone or with metformin may increase survival in high-risk prostate cancer patients

Among high-risk prostate cancer patients - those with high PSA and Gleason scores of 8 or more - many will develop a difficult-to-treat disease.

10 Feb 2020

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

An international clinical trial evaluating whether two investigational drugs can slow memory loss and cognitive decline in people in the early stages of a rare, inherited form of Alzheimer's disease has yielded disappointing results, an initial analysis of the data has shown.

10 Feb 2020

Common drug could mitigate risk of 'a broken heart' during bereavement

The increased risk of heart attack or "a broken heart" in early bereavement could be reduced by using common medication in a novel way, according to a world-first study led by the University of Sydney and funded by Heart Research Australia.

10 Feb 2020

High bacterial levels in half of lupus skin rashes

A new study published in the Journal of Investigative Dermatology reports that half the skin lesions present in patients with lupus show the presence of viable staph bacteria. This makes them more susceptible to skin infections and also increases the risk that the infection will spread to others.

9 Feb 2020

CRISPR-edited immune cells can be safely given to cancer patients

The emergence of CRISPR-Cas9 gene-editing technology has spurred hope in both doctors and patients since it shows promise in treating a multitude of diseases, including cancer. For the first time in the United States, a team of scientists has shown that CRISPR-edited immune cells can be safely used to cancer patients.

9 Feb 2020

Strategies to help patients breathe after trauma

Emergency Medicine and Trauma Surgery researchers at Vanderbilt University Medical Center are joining the Nashville Fire Department and nearly two dozen emergency medical service agencies across the country in a Department of Defense-funded clinical trial aimed at improving survival with breathing techniques used to keep patients alive at the scene of a trauma.

9 Feb 2020

New gene therapy improves vision in blind mice

Mice born blind have shown significant improvement in vision after undergoing a new gene therapy developed by a team of Japanese scientists.

7 Feb 2020

Gene therapy approach could pave the way for treatment of Stargardt disease

A leading Professor of Ophthalmology at the University of Oxford has shared the details of his research which could pave the way for a new treatment for sight loss condition Stargardt disease.

7 Feb 2020

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Clinical Trial News and Research

Moffitt research may provide a path toward improved multi-drug adaptive therapies

Understanding stress-induced bladder dysfunction in children

Nurse creates a self-management tool for patients with left ventricular assist device

To fight Chinese outbreak, doctors deploy drugs targeting HIV, malaria and Ebola

Combination of two antibiotics found to be no better than one for treating MRSA blood infections

New study confirms link between type 2 diabetes drug and increased risk of heart problems

Study evaluates feasibility of using T'ai Chi to improve chronic low back pain in older adults

Braincool completes patient recruitment to study Cooral System for prevention of Oral Mucositis

Depression treatment using AI, brain scans

New summary report highlights advances and challenges in small cell lung cancer research

New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

Statin use alone or with metformin may increase survival in high-risk prostate cancer patients

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

Common drug could mitigate risk of 'a broken heart' during bereavement

High bacterial levels in half of lupus skin rashes

CRISPR-edited immune cells can be safely given to cancer patients

Strategies to help patients breathe after trauma

New gene therapy improves vision in blind mice

Gene therapy approach could pave the way for treatment of Stargardt disease

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

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