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New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

SARS-CoV-2, the respiratory virus that causes COVID-19, attacks the body in multiple steps. Gaining entry into cells deep within the lungs and hijacking the human host cell's machinery to churn out copies of itself are two of the earliest steps -- both essential for viral infection.

9 Nov 2020

Researchers analyze metrics of cognitive decline in diverse Latinx populations

Alzheimer's disease and related dementias (ADRD) are degenerative brain diseases that affect over 5.8 million people in the U.S. Rates of ADRD are higher among Black and Latinx individuals compared to non-Latinx white individuals.

9 Nov 2020

Air pollution accounts for premature deaths from cardiovascular disease

In a current opinion article "Reduction of environmental pollutants for prevention of cardiovascular disease: it's time to act", published in the European Heart Journal this week.

9 Nov 2020

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Researchers at the Francis Crick Institute and University College London have found that some antibodies, created by the immune system during infection with common cold coronaviruses, can also target SARS-CoV-2 and may confer a degree of protection against the new viral strain.

9 Nov 2020

Social distancing policies had little effect on lower income people

A new Boston University School of Public Health study of the first four months of America's coronavirus epidemic, published in the journal Nature Human Behaviour, shows that physical distancing (also called "social distancing") policies had little effect.

9 Nov 2020

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed photoresponsive derivatives of the anticancer drug Taxol, which allow light-based control of cytoskeleton dynamics in neurons. The agents can optically pattern cell division and may elucidate how Taxol acts.

9 Nov 2020

Patients diagnosed with Parkinson's disease may actually have NIID, shows study

A joint study by the National Neuroscience Institute (NNI) and Singapore General Hospital (SGH) revealed that patients who have been diagnosed with Parkinson's disease might actually have NIID instead.

9 Nov 2020

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

The American College of Rheumatology (ACR) will preview its 2020 Guideline for the Management of Rheumatoid Arthritis (RA) at ACR Convergence, the ACR's annual meeting. The comprehensive, clinical recommendations for pharmacologic treatment of RA includes important updates to the previous guideline released in 2015.

9 Nov 2020

Study examines racial disparities in underinsurance

High deductible health plans (HDHPs) have become much more common among all racial/ethnic and income groups, but the health savings accounts (HSAs) that make these plans potentially workable are far less common among Black, Hispanic, and lower-income enrollees--and the gap is growing.

8 Nov 2020

Biden wins, but his health agenda dims with GOP likely to hold Senate

Former Vice President Joe Biden secured the 270 electoral votes needed to capture the White House on Saturday, major news organizations projected, after election officials in a handful of swing states spent days in round-the-clock counting of millions of mail-in ballots and early votes.

8 Nov 2020

Researchers to develop new optogenetic tools for biology and medicine

The European Research Council (ERC) is providing 10 million euros in funding for an interdisciplinary, collaborative project in the structural and biophysical analysis of selected photoreceptors and their development into "OptoGPCRs", light-controlled molecular switches with a wide range of applications in biology and medicine.

8 Nov 2020

Successful containment of COVID-19 in a Brazilian archipelago

The team of researchers in May 2020, headed by Ligia Regina Franco Sansigolo Kerr and Prof Costa Mendes, aimed to discuss and report the various control measures taken by FNA authorities in order to reduce the spread of SARS-CoV-2 virus in the Fernando de Noronha Archipelago (FNA). Their research is published on the preprint server medRxiv.

8 Nov 2020

As faith in vaccines falters, Biden is under pressure to name new FDA chief stat

President-elect Joe Biden made COVID-19 a linchpin of his campaign, criticizing President Donald Trump's leadership on everything from masks and packed campaign rallies to vaccines.

8 Nov 2020

New strategy shows promises for treating RNA-repeat expansion disorders

A new strategy for treating a variety of diseases known as RNA-repeat expansion disorders, which affect millions of people, has shown promise in proof-of-principle tests conducted by scientists at Scripps Research.

8 Nov 2020

Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care.

8 Nov 2020

Researchers compare rhesus and cynomolgus macaques for SARS-CoV-2 vaccine trials

A team of researchers at the Biomedical Primate Research Centre based in the Netherlands have aimed to determine the effects of the SARS-CoV-2 pathogen on these monkeys and, subsequently, whether they make good animal models for future research in the area.

8 Nov 2020

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

In a recent groundbreaking study, researchers from Stanford University demonstrated the potential of multiplexed targeted next-generation sequencing assay for detecting SARS-CoV-2 genetic fingerprints used in mutation profiling, with the potential of massive scalability required for population studies. The findings are currently available on the medRxiv preprint server.

8 Nov 2020

SARS-CoV-2 infection risk in day care centers for children and educators is low

Their findings suggest that SARS-CoV-2 infection rarely occurs in daycare centers, and thus, these centers should not be considered as potential reservoirs of the virus. The study is currently available on the medRxiv* preprint server.

8 Nov 2020

SARS-CoV-2 viral antigens found in non-pulmonary tissues in recovering patients

A team of researchers in Singapore, led by Dr. Joe Yeong, and Prof. Tony Kiat Hon Lim, have reported the presence of residual SARS-CoV-2 ribonucleic acid (RNA) – the virus' genetic material – in stool samples and gastrointestinal tissues from patients recovering from the coronavirus disease 2019 (COVID-19).

8 Nov 2020

Delirium common after hospital discharge in critically ill COVID-19 patients

Anesthesiologist and other researchers from Michigan Medicine, Ann Arbor, New York Medical College, Valhalla and Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, have reported a case series of critically ill coronavirus disease 2019 (COVID-19) patients who have developed neuropsychological symptoms after having been discharged from the hospital.

8 Nov 2020

Research News and Research

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

Researchers analyze metrics of cognitive decline in diverse Latinx populations

Air pollution accounts for premature deaths from cardiovascular disease

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Social distancing policies had little effect on lower income people

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

Patients diagnosed with Parkinson's disease may actually have NIID, shows study

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

Study examines racial disparities in underinsurance

Biden wins, but his health agenda dims with GOP likely to hold Senate

Researchers to develop new optogenetic tools for biology and medicine

Successful containment of COVID-19 in a Brazilian archipelago

As faith in vaccines falters, Biden is under pressure to name new FDA chief stat

New strategy shows promises for treating RNA-repeat expansion disorders

Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

Researchers compare rhesus and cynomolgus macaques for SARS-CoV-2 vaccine trials

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

SARS-CoV-2 infection risk in day care centers for children and educators is low

SARS-CoV-2 viral antigens found in non-pulmonary tissues in recovering patients

Delirium common after hospital discharge in critically ill COVID-19 patients

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