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Absence of anti-tumor protein may cause resistance to EGFR-targeting therapies

The absence of a protein that works to prevent tumor formation may explain why some patients are resistant to a common cancer therapy, according to Penn State College of Medicine researchers.

21 Dec 2020

Researchers examine whether regenerative patch for spina bifida defect can promote healing

Researchers are investigating whether a human umbilical cord patch placed on the spina bifida defect could improve healing after minimally invasive fetoscopic surgery in a clinical trial at The University of Texas Health Science Center at Houston.

14 Dec 2020

COVID-19 infection may also affect the central nervous system, cause neurological disorders

COVID-19 is known primarily as a respiratory disease, with symptoms that include cough, shortness of breath, and, in severe cases, acute respiratory distress syndrome and pneumonia

10 Dec 2020

Repair protein may prevent damage to healthy cells during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

9 Dec 2020

Experimental stem cell gene therapy may give a new lease of life for patient with sickle cell disease

"But it's a marathon whereas you keep going, the trail gets rockier and then you lose your shoes," the 27-year-old said. "It gets harder as you get older. Things start to fail and all you can think about is how much worse it's going to get down the road."

1 Dec 2020

Study demonstrates safety of novel immuno-oncology therapy in patients with advanced solid tumors

A novel therapy designed to help stimulate the body's immune system response against cancer appears to be safe to use as alone or in combination with immune checkpoint inhibitors.

1 Dec 2020

Innovative radiotherapy technique benefits patients with locally advanced cervical cancer

Patients with locally advanced cervical cancer benefit significantly from an innovative radiotherapy technique co-developed by MedUni Vienna under the direction of Richard Pötter and Christian Kirisits. The technique provides better tumor control and produces fewer side-effects.

26 Nov 2020

Implantable smart wrap may help people who have under-active bladders

An implantable smart wrap that fits safely and securely around the bladder may one day help people who have under-active bladders, a condition that hinders patients from urinating regularly and comfortably, according to an international team of researchers.

11 Nov 2020

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether Trop-2-expression and homologous recombination repair of SN-38-mediated double-strand DNA breaks play a role in the sensitivity of triple-negative breast cancer to SG.

3 Nov 2020

Machine learning increases the accuracy of anti-cancer drug response predictions

With the advent of pharmacogenomics, machine learning research is well underway to predict the patients' drug response that varies by individual from the algorithms derived from previously collected data on drug responses.

2 Nov 2020

Study: 1 in 8 patients with cancer have inherited gene mutations

Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine.

2 Nov 2020

Phase II NRG Oncology trial evaluates two regimens for muscle-invasive bladder cancer

Bladder preservation with trimodality therapy can be a safe and effective alternative to cystectomy for selected patients with muscle-invasive bladder cancer.

27 Oct 2020

Involving pediatric practices in promotion of private well water testing can influence parental compliance

Findings from a new study conducted by a team of researchers at Dartmouth's Geisel School of Medicine and published in the journal Preventive Medicine Reports, show that involving pediatric practices in the promotion of private well water testing can influence parental compliance.

27 Oct 2020

New approach can prevent aggressive operation in certain rectal cancer patients

A nonsurgical treatment option for rectal cancer that preserves quality of life is safe for carefully selected patients, according to a new study comparing it with the standard operation.

27 Oct 2020

New surgical tendon fixation system granted FDA 510(k) clearance

A new surgical tendon fixation system that not only re-attaches damaged tissues but also facilitates healing as it is absorbed by the body has been granted 510(k) clearance by the U.S. Food and Drug Administration, indicating that the device is "as safe and effective" as other legally marketed devices and is ready to go to market.

21 Oct 2020

Scientists uncover a novel cellular mechanism for disposing of misfolded proteins

About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin deficiency present with high variation in the severity of liver disease.

21 Oct 2020

Researchers discover gene that may help the body sense a full urinary bladder

In a National Institutes of Health (NIH)-funded study involving both mice and patients who are part of an NIH Clinical Center trial, researchers discovered that a gene, called PIEZO2, may be responsible for the powerful urge to urinate that we normally feel several times a day. The

19 Oct 2020

UH researcher receives $1.6 million to reverse urinary incontinence

A University of Houston researcher is working to reverse pelvic floor dysfunction which can result in urinary incontinence, a condition affecting 30-60% of the female population and 5-15% of males.

15 Oct 2020

Scientists find sensor protein that makes normal bladder function possible

A team co-led by scientists at Scripps Research has found that the main sensor protein enabling our sense of touch also underlies the feeling of having a full bladder and makes normal bladder function possible.

14 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Bladder News and Research

Absence of anti-tumor protein may cause resistance to EGFR-targeting therapies

Researchers examine whether regenerative patch for spina bifida defect can promote healing

COVID-19 infection may also affect the central nervous system, cause neurological disorders

Repair protein may prevent damage to healthy cells during cancer therapy

Experimental stem cell gene therapy may give a new lease of life for patient with sickle cell disease

Study demonstrates safety of novel immuno-oncology therapy in patients with advanced solid tumors

Innovative radiotherapy technique benefits patients with locally advanced cervical cancer

Implantable smart wrap may help people who have under-active bladders

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Machine learning increases the accuracy of anti-cancer drug response predictions

Study: 1 in 8 patients with cancer have inherited gene mutations

Phase II NRG Oncology trial evaluates two regimens for muscle-invasive bladder cancer

Involving pediatric practices in promotion of private well water testing can influence parental compliance

New approach can prevent aggressive operation in certain rectal cancer patients

New surgical tendon fixation system granted FDA 510(k) clearance

Scientists uncover a novel cellular mechanism for disposing of misfolded proteins

Researchers discover gene that may help the body sense a full urinary bladder

UH researcher receives $1.6 million to reverse urinary incontinence

Scientists find sensor protein that makes normal bladder function possible

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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