Endoplasmic reticulum (ER) News and Research

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High AngII levels put stress on the ER and cause hypertension

When the heart works too hard, the brain may be to blame, says new Cornell University research that is changing how scientists look at high blood pressure (hypertension). The study, published in the Journal of Clinical Investigation in November, traces hypertension to a newfound cellular source in the brain and shows that treatments targeting this area can reverse the disease.

18 Dec 2012

Children in asthma hotspots more likely to experience exercise-induced wheeze

Asthmatic children in New York City neighborhoods with high rates of asthma make many more visits to the emergency room (ER) than those who live in other parts of the city. While socioeconomic factors such as lack of adequate preventive care are part of the equation (high-asthma neighborhoods tend to be lower income), new research points to a possible biological basis for the disparity.

18 Dec 2012

Alexian Brothers Health System implements online service to reduce wait times in ERs

Hospitals across the country are investigating ways to improve their patients' experience through decreasing waiting times in emergency rooms and in immediate care settings.

17 Dec 2012

Delayed childbearing may protect against triple-negative breast cancer

Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study.

12 Dec 2012

ATLAS holds up 10-year tamoxifen regime

Results from the ATLAS study indicate that women with estrogen receptor-positive breast cancer should consider taking tamoxifen for up to 10 years after diagnosis.

10 Dec 2012

New data from AstraZeneca's FASLODEX studies on breast cancer to be presented at SABSC

AstraZeneca today announced the presentation of important new data from studies of FASLODEX (fulvestrant) Injection at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium taking place from 4-8 December at the Henry B. Gonzalez Convention Center, San Antonio, Texas.

5 Dec 2012

Researchers investigate GPER receptor as possible new drug target for breast cancer

Five-year breast cancer survival rates have improved dramatically over the past 50 years, but tumors can recur up to ten or more years after they are detected. When tumors recur, they are even more difficult to treat.

5 Dec 2012

Enzalutamide shows promise in treating triple-negative and estrogen-positive breast cancer

Breast cancers are defined by their drivers - estrogen and progesterone receptors (ER and PR) and HER2 are the most common, and there are drugs targeting each. When breast cancer has an unknown driver, it also has fewer treatment options - this aggressive form of breast cancer without ER, PR or HER2, which was thought not to be driven by hormones, is known as triple negative.

3 Dec 2012

Ansell introduces GAMMEX N95 Respirator and Surgical Mask

Ansell, a global leader in protection solutions today announced the latest addition to its Active Infection Protection (AIP) portfolio, the GAMMEX N95 Respirator and Surgical Mask, extending the AIP range beyond surgical gloves.

3 Dec 2012

Negative perceptions about generic drugs are more widespread among ethnic minorities

Negative perceptions about generic drugs are more widespread among ethnic minorities than among whites, finds a new study in Ethnicity & Disease.

1 Dec 2012

Eating disorders common in adolescents attending emergency department

A significant percentage of adolescents attending hospital emergency response departments have eating disorders, suggest results from a US study.

22 Nov 2012

Study finds 40% of surgery complications occur when patients are home

Meanwhile, in other hospital news, Bloomberg looks at the increasing number of emergency departments that offer online reservations.

22 Nov 2012

UPR pathway helps tumor cells escape apoptosis during development of lymphoma

A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.

21 Nov 2012

Facts about Homecare

Millions of seniors and people living with disabilities will enjoy Thanksgiving and other holidays in the comfort and safety of their own homes thanks to home medical equipment and services such as oxygen therapy, hospital beds, and wheelchairs.

21 Nov 2012

ER could be a good place to identify undiagnosed eating disorders among teens

Could the emergency room be a good place to spot undiagnosed eating disorders among teens, and help steer them to treatment? A new study from the University of Michigan suggests that could be the case.

20 Nov 2012

Five tips for safety at home during holidays

The holidays are a time to share joy with our friends, families and communities. They are also a time of great hustle and bustle with millions of us converging upon malls, salons and boutiques. The excitements experienced during the holidays are second only to the great memories we create.

19 Nov 2012

'Extended-skill' nurses, physiotherapists are as effective as the ER doc

Patients with peripheral soft tissue injuries achieve similar clinical outcomes when treated by emergency nurse practitioners and extended-scope physiotherapists in the emergency department, as when they are treated by doctors, show UK study results.

16 Nov 2012

Study examines public health impact of tamper resistant extended-release oxycodone

This is the first epidemiological study to examine the public health impact of a tamper resistant extended-release oxycodone (ORF). ER oxycodone was reformulated with physicochemical barriers to crushing and dissolving intended to reduce abuse through non-oral routes of administration.