Interferon News and Research

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Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

Review of natural products with promising anti-SARS-CoV-2 potential

In a new study, researchers reviewed existing literature on naturally active products with therapeutic efficacy against SARS-CoV-2.

10 Aug 2022

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

Researchers conducted phase 3 evaluations of the immunogenicity of the two immunization timeframes of the CoronaVac COVID-19 vaccine among Chilean adults.

10 Aug 2022

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Researchers assess the impact of extending the interval between primary and booster COVID-19 vaccine doses.

9 Aug 2022

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers from Spain have identified an immune expression signature in surgical specimens associated with disease progression for non-complete pathological responders patients treated with neo adjuvant chemo-immunotherapy, which could help the follow-up and therapeutic management of these high-risk patients.

8 Aug 2022

Researchers identify new therapies that could provide better protection against future COVID-19 variants

Researchers from the University of Kent in Canterbury, UK and the Goethe-University in Frankfurt am Main have identified new therapies for COVID-19 that could provide better protection against future variants and outbreaks.

8 Aug 2022

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A new study investigated how the gut microbiome confers immunity to mammalian hosts against SARS-CoV-2 intranasal infection by generating short-chain fatty acids.

5 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Hybrid immunity retained six months after SARS-CoV-2 exposure

Scientists hypothesize that lower death rates in COVID-19 patients may be due to hybrid immunity, as well as the reduced severity of Omicron infections.

3 Aug 2022

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.

3 Aug 2022

Memory B and T cell responses to the SARS-CoV-2 spike protein before and after the third BNT162b2 booster

Researchers evaluated memory B and T cell responses to SARS-CoV-2 before and after the third dose of the BNT162b2 vaccine.

3 Aug 2022

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

A new study revealed that the replication of the ancestral strain of SARS-CoV-2 is less efficient in nasal epithelial cells (NECs) of children.

3 Aug 2022

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Colorectal tumors are a common adverse effect of chronic inflammation of the intestine. In a new study, researchers from Japan and China demonstrate that mice models with dendritic cell immunoreceptor (DCIR) protein deficiency are resistant to colonic tumors induced by dextran sodium sulfate and azoxymethane.

2 Aug 2022

Interferon News and Research

Interferon beta reduces binding of three components to RBCs, study finds

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Review of natural products with promising anti-SARS-CoV-2 potential

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers identify new therapies that could provide better protection against future COVID-19 variants

Gut microbiota-derived metabolites offer protection against SARS-CoV-2

A combined influenza and COVID-19 mRNA vaccine

Hybrid immunity retained six months after SARS-CoV-2 exposure

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

Memory B and T cell responses to the SARS-CoV-2 spike protein before and after the third BNT162b2 booster

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Plasma myosin light chain 9 levels may be better predictor of COVID-19 severity than blood biomarkers

mRNA vaccines induce faster antibody response against infectious diseases

What is the role of vitamin D in pandemic H1N1 influenza and SARS-CoV-2 infection?

What is the immunopathogenesis of pediatric COVID-19?

Tannins as therapeutic agents against SARS-CoV-2

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