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Total ankle arthroplasty boosts patients' range of motion and improves quality of life

Surgical reconstruction is a life changer for people with end-stage ankle arthritis, a painful condition that limits patients' abilities to go up and down stairs, get out of a car and even walk.

6 Sep 2018

Lax oversight leaves surgery center regulators and patients in the dark

The first man died in April 2014. Another died later that month. Then on July 18 of that year, a woman was rushed to a hospital where she was told she was lucky to be alive.

9 Aug 2018

Women with PCOS more likely to have an autistic child

Women with polycystic ovary syndrome are more likely than other women to have an autistic child, according to an analysis of NHS data carried out by a team at Cambridge University's Autism Research Centre.

1 Aug 2018

Researchers identify genes linked to childhood nephrotic syndrome

Childhood nephrotic syndrome is the most frequently occurring chronic kidney disease among children. A Japanese research team has identified a group of genes that are strongly related to the development of childhood nephrotic syndrome.

27 Jul 2018

CNDA approves KEYTRUDA for treatment of advanced melanoma

Merck, known as MSD outside the United States and Canada, today announced that KEYTRUDA, Merck's anti-PD-1 therapy, has been approved by the China National Drug Administration for the treatment of adult patients with unresectable or metastatic melanoma following failure of one prior line of therapy.

26 Jul 2018

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Merck, known as MSD outside the United States and Canada, announced today that the pivotal Phase 3 KEYNOTE-048 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma, met a primary endpoint of overall survival as monotherapy in patients whose tumors expressed PD-L1.

25 Jul 2018

New Finnish study compares surgical treatment of shoulder impingement syndrome to placebo surgery

In a landmark study published this week in the BMJ, Finnish researchers show that one of the most common surgical procedures in the Western world is probably unnecessary.

19 Jul 2018

Researchers to investigate role of hormones in mosquito's ability to use human blood for egg production

Entomologists at the University of California, Riverside have received a five-year grant of $2.44 million from the National Institute of Allergy and Infectious Diseases, or NIAID, to investigate the role hormones play in the female mosquito's ability to use human blood for egg production.

16 Jul 2018

Prostate cancer test results may be affected by obesity, shows study

University of Adelaide research shows that the results of the most widely used test for prostate cancer may be affected by obesity.

5 Jul 2018

Glucose-based dietary supplement increases muscle-force in Duchenne muscular dystrophy mouse

A dietary supplement derived from glucose increases muscle-force production in the Duchenne muscular dystrophy mouse model by 50% in ten days, according to a study conducted by researchers from Université Laval's Faculty of Medicine and Centre hospitalier universitaire de Québec Research Centre-Université Laval.

30 Jun 2018

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for standard review a new supplemental Biologics License Application for KEYTRUDA, Merck's anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with resected, high-risk stage III melanoma and granted a Prescription Drug User Fee Act, or target action, date of February 16, 2019.

25 Jun 2018

Study provides insights into genetics underlying debilitating pediatric kidney disease

New research provides insights into the genetics underlying a debilitating kidney disease in children. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, could lead to new diagnostics and, ultimately, treatments.

14 Jun 2018

African-American men with prostate cancer show stronger response to hormone therapy

African-American men with advanced prostate cancer might be more responsive than white men to an anti-androgen drug and steroids, according to a study led by Duke Cancer Institute researchers.

4 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

Sex hormone levels linked to higher risk of heart disease in post-menopausal women

In post-menopausal women, having a higher blood level of a male hormone (testosterone) and a higher ratio of the male-type to-female type (estrogen) of hormones is associated with a higher risk of heart disease later in life, according to research published today in the Journal of the American College of Cardiology.

28 May 2018

New case report reveals negative clinical impact of using biotin supplement

A new case report in the Journal of the Endocrine Society documents how a patient's use of a common biotin supplement, also known as vitamin B7, caused her to have clinically misleading test results, which prompted numerous consultations and unnecessary radiographic and laboratory testing.

21 May 2018

Clinical study supports usual medical care plus chiropractic care for low back pain

U.S military personnel with low back pain who received usual medical care plus chiropractic care reported moderate improvement in their pain intensity and disability compared with patients who received usual medical care alone.

18 May 2018

Guideline revisions for knee osteoarthritis have 'subtle but significant' impact on clinical practice

Recent updates in evidence-based recommendations have led to changes in the use of steroid and hyaluronic acid injection for patients with osteoarthritis of the knee, reports a study in the May 16, 2018 issue of The Journal of Bone & Joint Surgery.

18 May 2018

International study finds viable treatment option for people with mild asthma

A large international study led by a Hamilton researcher has found a patient-centric treatment that works for people with mild asthma.

17 May 2018

FDA allows KU Medical Center to begin clinical trial of novel cellular therapy for HR/SR aGvHD

The University of Kansas Medical Center announced that the U.S. Food and Drug Administration has cleared it to begin a first-in-human clinical trial of MSCTC-0010 in patients with de novo high-risk acute or steroid-refractory acute graft-versus-host disease (HR/SR aGvHD).

16 May 2018