Transplant News and Research

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Xenotransplantation poised to become a clinical reality soon

Speaking today at the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation in Prague, Muhammad Mohiuddin, MBBS, said xenotransplantation, hailed as the future of organ transplantation, is poised to become a clinical reality within the next several years.

12 Apr 2024

AI will help heart transplant surgeons to better assess the factors impacting patient outcomes

Artificial intelligence will significantly impact the heart transplantation process by helping physicians better assess the complex factors impacting patient outcomes, according to researchers at today's Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation (ISHLT) in Prague.

10 Apr 2024

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma, the most common type of liver cancer, according to a clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and its Convergence Institute.

8 Apr 2024

Impella CP pump shows survival benefit in cardiogenic shock

Implantation of the Impella CP micro-axial flow pump in the hours after a heart attack significantly increased the rate of survival at six months among people suffering cardiogenic shock, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Study provides insights on lung transplantation in advanced age candidates

Data from the International Society for Heart and Lung Transplantation (ISHLT) indicates that the proportion of recipients aged 66 and above has risen to 19% by 2017.

8 Apr 2024

Interatrial shunt may offer differential benefits based on heart failure type

Patients with heart failure who had a small shunt inserted between the heart's left and right atria did not see any significant benefits overall compared with those who received a placebo procedure after a median of 22 months follow-up, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Hot climates worsen chronic kidney disease outcomes

Chronic kidney disease patients living in the hottest countries experienced an additional 8% drop in kidney function each year compared to those living in temperate climates, finds a new study from researchers at UCL and the London School of Hygiene & Tropical Medicine (LSHTM).

5 Apr 2024

Mayo Clinic, Terasaki Institute announce research collaboration for improving organ transplant outcomes

Mayo Clinic and Terasaki Institute for Biomedical Innovation announced today a research collaboration centered on improving organ transplant outcomes.

4 Apr 2024

Gene defect associated with argininosuccinic aciduria corrected using CRISPR-Cas9 technique

Argininosuccinate lyase deficiency (ASLD), also known as argininosuccinic aciduria, is a disease that has been enriched in the Finnish genetic heritage.

4 Apr 2024

Genetic analysis reveals hidden causes of chronic kidney disease in adults

Chronic kidney disease (CKD) is extremely prevalent among adults, affecting over 800 million individuals worldwide.

3 Apr 2024

New immunotherapy strategy potentially lays the groundwork for treating autoimmune diseases

Mayo Clinic scientists have developed an immunotherapy strategy that potentially lays the groundwork for treating a spectrum of autoimmune diseases.

1 Apr 2024

Turning back the clock on aging immune systems: New treatment rejuvenates elderly defenses

Study demonstrated that selectively reducing myeloid-biased hematopoietic stem cells (my-HSCs) in aged mice rejuvenated the immune system, enhanced lymphopoiesis, reduced inflammation, and improved responses to viral infection, highlighting a potential strategy for countering age-related immune decline.

31 Mar 2024

Unraveling gene regulation's role in pulmonary fibrosis

Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?

28 Mar 2024

Familial Alzheimer's transmissible through bone marrow transplants, study shows

Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show March 28 in the journal Stem Cell Reports.

28 Mar 2024

ABT199/venetoclax synergism with thiotepa enhances cytotoxicity of chemo drugs in AML cells

A new research paper was published in Oncotarget's Volume 15 on March 14, 2024, entitled, "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells."

26 Mar 2024

Study explores the role of health care algorithms in racial and ethnic disparities

For years, it was harder for Black patients to secure a coveted spot on the national kidney transplant waitlist because a clinical algorithm was making Black patients appear healthier than they were.

26 Mar 2024

Rising survival rates for AML patients over 65 after allogeneic hematopoietic stem cell transplant

Among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.

22 Mar 2024

Study highlights global fertility decline and its implications for the future

The world is approaching a low-fertility future. Although by 2100 more than 97% of countries and territories will have fertility rates below what is necessary to sustain population size over time, comparatively high fertility rates in numerous low-income countries, predominantly in western and eastern sub-Saharan Africa, will continue to drive population increases in these locations throughout the century.

21 Mar 2024

Advancing computational pathology with UNI and CONCH foundation models

Foundation models, advanced artificial intelligence systems trained on large-scale datasets, hold the potential to provide unprecedented advancements for the medical field.

19 Mar 2024

Rising antifungal resistance heightens concerns over invasive fungal infections

A global wave of infections caused by fungi growing drug-resistant has the medical community issuing precautions on how to protect yourself.

18 Mar 2024

Transplant News and Research

Xenotransplantation poised to become a clinical reality soon

AI will help heart transplant surgeons to better assess the factors impacting patient outcomes

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Impella CP pump shows survival benefit in cardiogenic shock

Study provides insights on lung transplantation in advanced age candidates

Interatrial shunt may offer differential benefits based on heart failure type

Hot climates worsen chronic kidney disease outcomes

Mayo Clinic, Terasaki Institute announce research collaboration for improving organ transplant outcomes

Gene defect associated with argininosuccinic aciduria corrected using CRISPR-Cas9 technique

Genetic analysis reveals hidden causes of chronic kidney disease in adults

New immunotherapy strategy potentially lays the groundwork for treating autoimmune diseases

Turning back the clock on aging immune systems: New treatment rejuvenates elderly defenses

Unraveling gene regulation's role in pulmonary fibrosis

Familial Alzheimer's transmissible through bone marrow transplants, study shows

ABT199/venetoclax synergism with thiotepa enhances cytotoxicity of chemo drugs in AML cells

Study explores the role of health care algorithms in racial and ethnic disparities

Rising survival rates for AML patients over 65 after allogeneic hematopoietic stem cell transplant

Study highlights global fertility decline and its implications for the future

Advancing computational pathology with UNI and CONCH foundation models

Rising antifungal resistance heightens concerns over invasive fungal infections

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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