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New topical gel can prevent pesticide-induced toxicity and lethality

Farmers are exposed to toxic pesticides, through skin contact and inhalation, during the spraying of pesticides. This is a severe health hazard. In the last year, from the Vidharbha region in Maharashtra alone, spraying is thought to have led to over 40 deaths, 25 cases of lost vision, and over 1000 hospitalizations.

22 Oct 2018

Researchers discover how acne-causing bacteria resist treatment

Researchers in Sweden have discovered how acne-causing bacteria feed off their human hosts. The study, which was performed at KTH Royal Institute of Technology, could make it possible to find effective ways to treat severe acne.

22 Oct 2018

IDT to demonstrate CRISPR expertise at European-focused events

As an advocate for the genomics age, Integrated DNA Technologies (IDT), will showcase its renowned CRISPR expertise at a series of European-focused events.

From Integrated DNA Technologies 22 Oct 2018

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with KEYTRUDA (pembrolizumab), Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas.

22 Oct 2018

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating KEYTRUDA, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ or CIS plus papillary disease (Cohort A).

22 Oct 2018

Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC

Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG (brigatinib) compared to crizotinib among anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) patients.

22 Oct 2018

Newly discovered toxin stands out from others in the battle for microbial domination

A newly discovered toxin that some bacteria deploy to fend off competing bacteria stands out from others in the battle for microbial domination. While many deadly substances have been identified among bacteria, this previously unknown toxin behaves in a familiar way.

19 Oct 2018

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions.

19 Oct 2018

Duke researchers find way to detect blood doping in athletes

A Duke University research team has found a way to help sporting officials detect whether an athlete's blood has been doped by an infusion of their own stored blood.

19 Oct 2018

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

UT Southwestern biochemist Dr. Zhijian "James" Chen today was named winner of the prestigious 2019 Breakthrough Prize in Life Sciences for his discovery of the cGAS enzyme that launches the body's immune defense against infections and cancers.

19 Oct 2018

People with more copies of AMY1 gene digest starchy carbohydrates faster

Found in saliva, the protein enzyme encoded by the AMY1 gene begins the digestive process by breaking down starch when you chew your food.

19 Oct 2018

Scripps researchers successfully test potential new smoking-cessation treatment in rodents

Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.

19 Oct 2018

New urea sorbent could speed up the development of wearable artificial kidney

There just aren't enough kidney transplants available for the millions of people with renal failure.

19 Oct 2018

Genetically modifying zebrafish provides numerous, highly accurate disease models

Research published today describes how zebrafish can be genetically engineered to produce more accurate models of human disease.

18 Oct 2018

FDA grants Rare Pediatric Disease Designation for Immusoft’s Iduronicrin genleukocel-T

Immusoft Corporation, a Seattle-Wash.-based cell therapy company, announced today that the U.S. Food and Drug Administration (FDA) has granted it Rare Pediatric Disease Designation (RPDD) for Iduronicrin genleukocel-T, Immusoft's Sleeping Beauty transposon-engineered autologous plasmablasts for the expression and delivery of alpha-L-iduronidase (IDUA) to treat Mucopolysaccharidosis type I (MPS I).

17 Oct 2018

Simple, inexpensive test quickly detects antibiotic-resistant 'superbugs'

When you get sick, you want the right treatment fast. But certain infectious microbes are experts at evading the very anti-bacterial drugs designed to fight them.

16 Oct 2018

Modeling Non-Numerical Data in Systems Biology

An interview with Dr. Eshan Mitra, discussing the importance of computer models in biology and the development of a more accurate model of the RAF phosphorylation pathway.

15 Oct 2018

Researchers to study the use of CRISPR on human liver on-a-chip platform

Two Arizona State University professors are among the first recipients of Somatic Cell Genome Editing grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver on-a-chip" platform.

15 Oct 2018

Gut microbiota could play greater role in pathogenesis of MS than previously thought

In multiple sclerosis, a defective response of the body’s own immune system leads to brain tissue damage. Gastrointestinal microbiota could play a far greater role in the pathogenesis of the disease than previously assumed, researchers at the University of Zurich have now found.

11 Oct 2018

Scientists discover molecular link between body weight and early-onset puberty

Becoming overweight at a young age can trigger a molecular chain reaction that leads some girls to experience puberty early, according to new research published in Nature Communications.

11 Oct 2018

Enzyme News and Research

New topical gel can prevent pesticide-induced toxicity and lethality

Researchers discover how acne-causing bacteria resist treatment

IDT to demonstrate CRISPR expertise at European-focused events

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC

Newly discovered toxin stands out from others in the battle for microbial domination

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

Duke researchers find way to detect blood doping in athletes

UT Southwestern biochemist receives 2019 Breakthrough Prize in Life Sciences for innate immunity discovery

People with more copies of AMY1 gene digest starchy carbohydrates faster

Scripps researchers successfully test potential new smoking-cessation treatment in rodents

New urea sorbent could speed up the development of wearable artificial kidney

Genetically modifying zebrafish provides numerous, highly accurate disease models

FDA grants Rare Pediatric Disease Designation for Immusoft’s Iduronicrin genleukocel-T

Simple, inexpensive test quickly detects antibiotic-resistant 'superbugs'

Modeling Non-Numerical Data in Systems Biology

Researchers to study the use of CRISPR on human liver on-a-chip platform

Gut microbiota could play greater role in pathogenesis of MS than previously thought

Scientists discover molecular link between body weight and early-onset puberty

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Advancing degrader and proximity-based drug development

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