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A quest to unlock the genetic code of SARS-CoV-2

How the novel coronavirus that causes COVID-19 made the leap from animals to humans is a puzzle that scientists are trying to solve as humanity comes to grip with the deadly pandemic sweeping the globe.

26 Mar 2020

Jumping genes help make functional brain cells in a lab dish

The process of making functional brain cells in a lab dish requires the precise activation of selfish genetic elements known as LINE-1 (L1) retrotransposons.

26 Mar 2020

Anteater-like animals are the missing link for coronavirus transmission between bats and humans

As scientists scramble to learn more about the SARS-CoV-2 coronavirus, two recent studies of the virus' genome reached controversial conclusions: namely, that snakes are intermediate hosts of the new virus, and that a key coronavirus protein shares "uncanny similarities" with an HIV-1 protein.

26 Mar 2020

Finding new treatments for muscular dystrophy with CRISPR-Cas9

A new study out of Boston's Children's Hospital has used the gene-editing tool CRISPR-Cas9 to explore the fatal genetic condition called facioscapulohumeral dystrophy (FSHD, one of the family of muscular dystrophies), and to test out the potential utility of various genes involved in this disorder. The research is published in the journal Science Translational Medicine.

25 Mar 2020

Russian researchers explain why new pathogenic viruses are so hard to detect

In a recently published fundamental review dedicated to the diagnostics of viral infections, a Russian research team featuring MIPT researchers was the first to systematically describe and summarize the cutting-edge technologies in the rapidly developing field of genetics.

25 Mar 2020

Researchers aim to find the genetic basis of severe coronavirus infection in young people

Hundreds of clinicians worldwide are banding together in an effort to study some types of severe cases of the new coronavirus disease.

25 Mar 2020

Advancing CAR T-cell therapy for treatment of solid tumors

The full title of the research is "The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors"; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab (a resident of Skolkovo).

25 Mar 2020

A genetic toolkit to produce multifunctional magnetic nanoparticles

Magnetic bacteria might soon be used for the production of novel biomaterials. A team of microbiologists at the University of Bayreuth led by Prof. Dr. Dirk Schüler developed a modular system for the genetic reprogramming of bacteria, thereby turning the organisms into cell factories for multifunctional magnetic nanoparticles that combine various useful functions and properties.

25 Mar 2020

Mapping the cannabis genome to improve agriculture and human health

Unlocking the full potential of cannabis for agriculture and human health will require a co-ordinated scientific effort to assemble and map the cannabis genome, says a just-published international study led by University of Saskatchewan researchers.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Study explores genetic mechanisms underlying resistance to leishmaniasis

In an article published in Scientific Reports, researchers affiliated with the University of São Paulo in Brazil describe experiments performed with mice that show how genetic factors can determine whether an individual is susceptible or resistant to leishmaniasis.

24 Mar 2020

Humans are not the first to exploit benefits of CRISPR technique, research shows

In recent years, the development of CRISPR technologies and gene-editing scissors in particular have taken the world by storm. Indeed, scientists have learned how to harness these clever natural systems in the biotech and pharmaceutical industries, among other areas.

24 Mar 2020

Study: Bacterial protein fragment instigates lung tissue death in pulmonary fibrosis

A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan.

24 Mar 2020

The COVID-19 vaccine pipeline

Major nations are in a race to make an effective vaccine that could help treat the novel coronavirus infection COVID-19. As hundreds of thousands are infected across the world and over sixteen thousand killed, the pandemic shows no signs of relenting.

23 Mar 2020

New £5 million funding to help increase the understanding of Covid-19

The University of Edinburgh has received nearly £5 million to tackle the coronavirus pandemic from the government's rapid response call.

23 Mar 2020

Scientists discover new genetic editing powers in squid

Revealing yet another super-power in the skillful squid, scientists have discovered that squid massively edit their own genetic instructions not only within the nucleus of their neurons, but also within the axon -- the long, slender neural projections that transmit electrical impulses to other neurons.

23 Mar 2020

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the study of prostate cancer patients with family histories of the disease.

23 Mar 2020

High blood pressure and obesity shown to be two strongest risk factors for shortening lifespan

A team have demonstrated that high blood pressure and obesity are the two strongest risk factors of shortening our lifespan.

23 Mar 2020

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Immunotherapy that involves treating cancer with the body's own immune cells, or those of a matched donor, shows promise in clinical trials for some patients, but not all.

22 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

Genome News and Research

A quest to unlock the genetic code of SARS-CoV-2

Jumping genes help make functional brain cells in a lab dish

Anteater-like animals are the missing link for coronavirus transmission between bats and humans

Finding new treatments for muscular dystrophy with CRISPR-Cas9

Russian researchers explain why new pathogenic viruses are so hard to detect

Researchers aim to find the genetic basis of severe coronavirus infection in young people

Advancing CAR T-cell therapy for treatment of solid tumors

A genetic toolkit to produce multifunctional magnetic nanoparticles

Mapping the cannabis genome to improve agriculture and human health

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Study explores genetic mechanisms underlying resistance to leishmaniasis

Humans are not the first to exploit benefits of CRISPR technique, research shows

Study: Bacterial protein fragment instigates lung tissue death in pulmonary fibrosis

The COVID-19 vaccine pipeline

New £5 million funding to help increase the understanding of Covid-19

Scientists discover new genetic editing powers in squid

Study identifies ancestral fragments of DNA associated with hereditary prostate cancer

High blood pressure and obesity shown to be two strongest risk factors for shortening lifespan

Using 'young NK cells' could improve the effectiveness of immunotherapy for cancer patients

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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