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SeraCare Life Sciences inks CRADA with NCI to create positive controls for cancer assays

SeraCare Life Sciences, a leading partner to global in vitro diagnostics manufacturers, today announced that it has signed a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute, part of the National Institutes of Health, to create reference materials and positive controls for cancer assays.

26 Jun 2015

New Internet tool may help analyze genes based on their evolutionary profile

Two major revolutions, one genomic and one in informatics, are completely changing the face of biomedical research. Every day all over the world, millions of genetic sequences -- from disease-related genes to complete genomes of plants, animals, bacteria and viruses -- are resolved, identified and dissected.

26 Jun 2015

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Investigators from Dartmouth's Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

25 Jun 2015

Study: Acellular vaccines may have contributed to recent pertussis outbreak

Whooping cough has made an astonishing comeback, with 2012 seeing nearly 50,000 infections in the U.S. (the most since 1955), and a death rate in infants three times that of the rest of the population.

25 Jun 2015

Medical students show greater acceptance of using approaches in genomic medicine than practicing physicians

Medical students showed a greater acceptance of using approaches in genomic medicine, a key element in the practice of precision medicine, to treat patients as compared to physicians currently in practice according to a Brief Communication in the journal Medical Science Educator.

24 Jun 2015

Broad Institute teams up with Google to increase access to research tools

Broad Institute of MIT and Harvard is teaming up with Google Genomics to explore how to break down major technical barriers that increasingly hinder biomedical research by addressing the need for computing infrastructure to store and process enormous datasets, and by creating tools to analyze such data and unravel long-standing mysteries about human health.

24 Jun 2015

Johns Hopkins researchers identify multiple genetic changes that may increase risk of pancreatic cancer

In a genome-wide association study believed to be the largest of its kind, Johns Hopkins researchers have uncovered four regions in the human genome where changes may increase the risk of pancreatic cancer.

24 Jun 2015

Scientific collaboration pinpoints genetic cause of rare form of blindness in newborn babies

A scientific collaboration, involving the Manchester Centre for Genomic Medicine at Saint Mary's Hospital, UK, and the Telethon Institute of Genetics and Medicine in Naples, Italy, has pinpointed the genetic cause of a rare form of blindness, which can present itself as a key-hole shaped defect in the eye in newborn babies.

24 Jun 2015

Advanced Cell Diagnostics raises $22 million in Series C equity financing

Advanced Cell Diagnostics, Inc., a world leader in the field of in situ nucleic acid detection for life science research and clinical diagnostics, announced today that it has raised $22 million in Series C equity financing, led by growth equity investor Summit Partners with participation from Kenson Ventures and existing investors, Morningside Ventures and New Leaf Venture Partners.

From Advanced Cell Diagnostics 22 Jun 2015

The Lancet Oncology publishes results of CYRAMZA (ramucirumab) Phase III trial for HCC treatment

Eli Lilly and Company announced that The Lancet Oncology has published results of the Phase III REACH trial that evaluated CYRAMZA (ramucirumab) as a second-line treatment for people with hepatocellular carcinoma (HCC), also known as liver cancer. While the REACH trial's primary endpoint of overall survival favored the CYRAMZA arm, it was not statistically significant.

19 Jun 2015

UNC Lineberger scientists contribute to better understanding of genetic mutations in melanoma

UNC Lineberger Comprehensive Cancer Center researchers have significantly contributed to a better understanding of the genetic alterations found in cutaneous melanoma, the most lethal form of skin cancer, as part of a multi-institution, international effort of The Cancer Genome Atlas.

19 Jun 2015

Scientists identify four melanoma subtypes that share common 'downstream' signaling pathways

Cutaneous melanoma, the most deadly form of skin cancer, is now believed to be divided into four distinct genomic subtypes, say researchers at The University of Texas MD Anderson Cancer Center, a finding that could prove valuable in the ever-increasing pursuit of personalized medicine.

19 Jun 2015

Mayo Clinic, TGen researchers help launch national clinical trial to treat advanced skin cancer patients

Mayo Clinic and the Translational Genomics Research Institute are helping launch a national clinical trial that will apply the latest in precision medicine to treat advanced melanoma skin cancer.

19 Jun 2015

International researchers identify previously unknown genetic immunodeficiency

An analysis of five families has revealed a previously unknown genetic immunodeficiency, says an international team led by researchers from Boston Children's Hospital. The condition, linked to mutations in a gene called DOCK2, deactivates many features of the immune system and leaves affected children open to a unique pattern of aggressive, potentially fatal infections early in life.

19 Jun 2015

Study demonstrates potential of new approach for sorting out BRCA1 gene variants

Patients seeking certainty in genetic tests often receive a perplexing result. Many learn they carry a 'variant of unknown significance' of a disease-linked gene. Such variants might -- or equally might not -- increase disease risk.

19 Jun 2015

Researchers find new way to potentially stop progression of late-stage cancers

An international research team led by Mayo Clinic oncologists has found a new way to identify and possibly stop the progression of many late-stage cancers, including bladder, blood, bone, brain, lung and kidney.

18 Jun 2015

Key lessons from Middle East Respiratory Syndrome outbreak in South Korea

The outbreak of Middle East Respiratory Syndrome (MERS) in South Korea is the subject of a fast-tracked editorial in the International Journal of Infectious Diseases, written by Dr. Eskild Petersen and colleagues.

18 Jun 2015

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Since the 2009 discovery that energy-burning brown fat can be active in adults, research has raced ahead to understand this tissue and exploit it to treat the epidemic of obesity. Active brown fat also may assist in directly easing the burden of diabetes and related metabolic diseases by lowering the levels of glucose and fatty acids in the bloodstream. But progress in studying human brown fat often has been slowed by difficulties in obtaining and studying samples of the human cells that develop into brown fat.

17 Jun 2015

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress. This gene may also be an Achilles' heel when treating certain tumors, according to a team of researchers at The University of Texas MD Anderson Cancer Center.

12 Jun 2015

Dell extends partnership with TGen to globally expand precision medicine trial for pediatric cancer

Dell today announced its extended partnership with the Translational Genomics Research Institute to help clinical researchers and doctors globally expand the reach and impact of the world's first Food and Drug Administration-approved precision medicine trial for pediatric cancer.

11 Jun 2015

Genomic News and Research

SeraCare Life Sciences inks CRADA with NCI to create positive controls for cancer assays

New Internet tool may help analyze genes based on their evolutionary profile

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Study: Acellular vaccines may have contributed to recent pertussis outbreak

Medical students show greater acceptance of using approaches in genomic medicine than practicing physicians

Broad Institute teams up with Google to increase access to research tools

Johns Hopkins researchers identify multiple genetic changes that may increase risk of pancreatic cancer

Scientific collaboration pinpoints genetic cause of rare form of blindness in newborn babies

Advanced Cell Diagnostics raises $22 million in Series C equity financing

The Lancet Oncology publishes results of CYRAMZA (ramucirumab) Phase III trial for HCC treatment

UNC Lineberger scientists contribute to better understanding of genetic mutations in melanoma

Scientists identify four melanoma subtypes that share common 'downstream' signaling pathways

Mayo Clinic, TGen researchers help launch national clinical trial to treat advanced skin cancer patients

International researchers identify previously unknown genetic immunodeficiency

Study demonstrates potential of new approach for sorting out BRCA1 gene variants

Researchers find new way to potentially stop progression of late-stage cancers

Key lessons from Middle East Respiratory Syndrome outbreak in South Korea

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

Dell extends partnership with TGen to globally expand precision medicine trial for pediatric cancer

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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