Clinical Trial News and Research

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Human genetics evidence predictive of drug development success, study shows

A new drug candidate is more likely to be approved for use if it targets a gene known to be linked to the disease; a finding that can help pharmaceutical companies to focus their drug development efforts.

From PLOS ONE 13 Dec 2019

People living with HIV are willing to risk near-certain death in clinical trial

Nearly one-quarter of people living with HIV were willing to risk near-certain death in a clinical trial, if volunteering for the trial would help find a cure for the disease, according to the new study "HIV Cure Research."

13 Dec 2019

10-year results from clinical trial of extended letrozole therapy for women with HR+ breast cancer

In the updated results from NRG Oncology/NSABP B-42 trial through 10 years of observation, extending letrozole therapy for additional five years after five years of adjuvant endocrine therapy resulted in a statistically significant improvement in the 10-year disease-free survival (DFS) of postmenopausal women with hormone-receptor-positive breast cancer.

12 Dec 2019

New methodologies could help premature babies breathe easy

When a premature baby is born, the immediate challenge is to ensure it breathes easily without outside help. A new study shows that by carefully supplying 100% oxygen to these fragile scraps of humanity, independent breathing can be initiated much faster.

12 Dec 2019

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

One of most potent drugs for treatment of glioblastoma, the most deadly type of brain tumor, can't be used in patients because of two problems. First, it can't reach its target because it's blocked by the blood-brain barrier, a microscopic structure that protects the brain from toxins in the blood. And the conventional formulation for this drug is toxic to the brain.

12 Dec 2019

Study looks at flu vaccine requirement for children, caregivers in U.S. child care centers

Influenza can be especially dangerous for children, who are at greater risk for serious complications from the illness, including hospitalization and even death.

12 Dec 2019

Artificial Intelligence (AI) in Cancer Care

Artificial intelligence (AI) is being tested in clinics around the world, but is it a realistic ambition to apply sophisticated algorithms to cancer care?

From IBM Watson 12 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Non-drug therapies may reduce adverse outcomes in service members with chronic pain

A new study based on Veterans Affairs health records finds that non-drug therapies given to military service members with chronic pain may reduce the risk of long-term adverse outcomes, such as alcohol and drug disorder and self-induced injuries, including suicide attempts.

11 Dec 2019

Efforts to prevent new HIV transmissions must also focus on people already living with HIV

Efforts to prevent new HIV transmissions in the United States must be accompanied by advances in addressing HIV-associated comorbidities to improve the health of people already living with HIV, National Institutes of Health experts assert in the third of a series of JAMA commentaries.

11 Dec 2019

Treatment combination improves survival in advanced HER2-positive breast cancer patients

Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.

11 Dec 2019

Blood test could be a better way of guiding treatment for advanced breast cancer patients

A blood test can help identify rare mutations in advanced breast cancer, which may enable patients to access effective treatments more quickly in the future, Cancer Research UK scientists have found.

11 Dec 2019

IONTAS antibody for the treatment of B-Cell ALL receives approval for clinical trials

IONTAS Limited, a leader in the discovery and optimization of fully human antibodies, has been informed that International Biotechnology Center Generium, a leading Russian biopharmaceutical company, focused on developing and commercializing pharmaceutical products for the treatment of orphan diseases and cancer, has received approval from the Russian Health Authorities to initiate clinical trials with its CD3/CD19 bispecific antibody for the treatment of B-Cell Acute Lymphoblastic Leukemia.

From FairJourney Biologics 11 Dec 2019

Clinical trial eligibility criteria may be excessive, needlessly excluding patients

Federal regulations may keep lung cancer patients out of clinical trials simply because these patients are on medications that might affect the electrical system of the heart. Drilling into the details quickly turns up reasons to think these regulations may be preventing a substantial proportion of patients from participating in clinical trials.

10 Dec 2019

Huntington's disease patients need to better understand the risks and benefits of new therapies

For patients with Huntington's disease (HD), clinical trials can offer hope when there are no treatments available despite unknowns about whether the therapy will work or is safe.

10 Dec 2019

New joint venture aims to develop implantable cell therapies for debilitating conditions with no cure

Mayo Clinic and W. L. Gore & Associates Inc., a global materials science company, have formed a joint venture to advance the development of implantable cell therapies to treat debilitating conditions with no cure. Avobis Bio will combine Mayo Clinic's clinical and cell expertise and Gore's expertise in material sciences to address some of the most challenging medical issues.

10 Dec 2019

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

In a clinical trial led by Yale Cancer Center and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer.

10 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Neurons in the brain's motor cortex light up during speech of words and syllables

Neurons in the brain's motor cortex previously thought of as active mainly during hand and arm movements also light up during speech in a way that is similar to patterns of brain activity linked to these movements, suggest new findings published today in eLife.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Clinical Trial News and Research

Human genetics evidence predictive of drug development success, study shows

People living with HIV are willing to risk near-certain death in clinical trial

10-year results from clinical trial of extended letrozole therapy for women with HR+ breast cancer

New methodologies could help premature babies breathe easy

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

Study looks at flu vaccine requirement for children, caregivers in U.S. child care centers

Artificial Intelligence (AI) in Cancer Care

New drug combo promises help for triple negative breast cancer patients

Non-drug therapies may reduce adverse outcomes in service members with chronic pain

Efforts to prevent new HIV transmissions must also focus on people already living with HIV

Treatment combination improves survival in advanced HER2-positive breast cancer patients

Blood test could be a better way of guiding treatment for advanced breast cancer patients

IONTAS antibody for the treatment of B-Cell ALL receives approval for clinical trials

Clinical trial eligibility criteria may be excessive, needlessly excluding patients

Huntington's disease patients need to better understand the risks and benefits of new therapies

New joint venture aims to develop implantable cell therapies for debilitating conditions with no cure

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Neurons in the brain's motor cortex light up during speech of words and syllables

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

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