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New joint initiative to explore clinical interpretation of molecular tests for cancers

A new conference helping doctors navigate one of the most important scientific questions faced by the cancer community could help improve survival rates for patients.

23 Oct 2015

MU researchers successfully treat dogs with DMD, plan for human clinical trials

Muscular dystrophy, which affects approximately 250,000 people in the U.S., occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function. For years, scientists have searched for a way to successfully treat the most common form of the disease, Duchenne Muscular Dystrophy (DMD), which primarily affects boys. Now, a team of University of Missouri researchers have successfully treated dogs with DMD and say that human clinical trials are being planned in the next few years.

23 Oct 2015

Stem cell biology and gene-editing techniques offer hope for kidney regeneration

Mini-kidney organoids have now been grown in a laboratory by using genome editing to re-create human kidney disease in petri dishes.

23 Oct 2015

Potential new drug target for acute myeloid leukemia

New treatment options are badly needed for acute myeloid leukemia, a relatively rare form of cancer. The malignancy begins in the bone marrow, and from there can spread rapidly to the bloodstream, depriving the body of the essential blood cells that carry oxygen and fight infections.

23 Oct 2015

Successful treatment of rare neurodegenerative disease exemplifies potential of precision medicine

A 20-month-old girl suffering from a rare neurodegenerative disease was diagnosed by exome sequencing and successfully treated.

23 Oct 2015

Juneau Biosciences presents new genetic discoveries in endometriosis at annual ASRM meeting

This week, Juneau Biosciences, LLC presented new discoveries concerning the genetics of endometriosis at the annual American Society of Reproductive Medicine (ASRM) meeting in Baltimore, MD.

23 Oct 2015

Early trial results in lung cancer

Results from early phase trials investigating different therapeutic agents in lung cancer patients were presented during the third Presidential Session at the European Cancer Congress in Vienna, Austria. Here we summarise two studies reported at the session.

22 Oct 2015

Psychiatric symptoms predate motor onset in Huntington’s disease

Prodromal psychiatric symptoms may be more common in patients with Huntington’s disease than previously thought and worsen as the condition progresses, longitudinal study findings show.

22 Oct 2015

New study from TSRI and Salk points to cause of debilitating nerve disease

Scientists at The Scripps Research Institute (TSRI) and the Salk Institute for Biological Studies have discovered how a mutant protein triggers nerve damage in a subtype of Charcot-Marie-Tooth (CMT) diseases, a group of currently untreatable conditions that cause loss of function in a person’s hands and feet.

22 Oct 2015

Ground-breaking discovery helps scientists view DNA damage with crystal clarity

Scientists have developed a new technique for looking at the initial steps of DNA oxidation – a process which can lead to DNA damage, mutations and cancers. The breakthrough, which uses DNA in crystals, should help related research in the fields of cancer medicine and drug development.

22 Oct 2015

Bioengineers develop continuously tunable method to find and quantify DNA, RNA biomarkers

A Rice University laboratory has developed a continuously tunable method to find and quantify DNA and RNA biomarkers.

20 Oct 2015

Scientists reveal link between depression and paraventricular thalamus

Scientists from the RIKEN Brain Science Institute have shown that a mouse strain with a mutation that leads to dysfunction of mitochondria--the "powerhouses" that provide energy to cells--spontaneously undergo periodic episodes of depression-like behavior that resemble those in human. Through this research, published in Molecular Psychiatry, the scientists uncovered a link between depression and the paraventricular thalamus, a region of the brain not previously tied to depression.

20 Oct 2015

Sequenom enters into clinical collaboration with CU School of Medicine

Sequenom, Inc., a life sciences company committed to enabling healthier lives through the development of innovative products and services, today announced that it has entered into a clinical collaboration with the University of Colorado Denver, School of Medicine.

19 Oct 2015

Breakthrough advancements on new molecular mechanism may lead to Parkinson's treatments

More than one million people in the United States are afflicted with Parkinson's disease, a progressive disorder of the brain that affects movement and coordination. The cause is typically unknown, and presently there is no cure for the disease.

19 Oct 2015

UB study sheds light on the root causes of Huntington's disease

We've known for years that the Huntingtin protein (Htt) is responsible for Huntington's disease, a neurodegenerative disorder that diminishes a person's mental and physical abilities.

19 Oct 2015

UAMS researchers report positive results from treating Metastatic Merkel-cell carcinoma with idelalisib drug

Identifying a patient's genetic mutation led University of Arkansas for Medical Sciences (UAMS) physician-researcher Ling Gao, M.D., Ph.D., to an existing drug that eliminated the patient's stage IV Merkel-cell carcinoma. Gao's findings, made in collaboration with two other UAMS researchers, were published today in The New England Journal of Medicine.

19 Oct 2015

Genetic mutation linked to ALS, FTD prevents proteins from entering and exiting the cell's nucleus

Three teams of scientists supported by the National Institutes of Health showed that a genetic mutation linked to some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) may destroy neurons by disrupting the movement of materials in and out of the cell's nucleus, or command center where most of its DNA is stored.

19 Oct 2015

Camels in Kenya infected by MERS virus, new study finds

A new study has found that nearly half of camels in parts of Kenya have been infected by the virus that causes Middle East Respiratory Syndrome (MERS) and calls for further research into the role they might play in the transmission of this emerging disease to humans.

19 Oct 2015

CNIO researchers identify molecular mechanisms that determine cancer predisposition in DBA patients

Researchers from the Tumour Suppression Group at the Spanish National Cancer Research Centre, headed by Manuel Serrano, have discovered the molecular mechanisms that determine cancer predisposition in patients with Diamond-Blackfan anaemia (DBA).

18 Oct 2015

New zebrafish study provides insights into causes of congenital heart defects

Researchers working with zebrafish at New Zealand's University of Otago have published a study providing new insights into the causes of the congenital heart defects associated with a rare developmental disorder.

16 Oct 2015

Mutation News and Research

New joint initiative to explore clinical interpretation of molecular tests for cancers

MU researchers successfully treat dogs with DMD, plan for human clinical trials

Stem cell biology and gene-editing techniques offer hope for kidney regeneration

Potential new drug target for acute myeloid leukemia

Successful treatment of rare neurodegenerative disease exemplifies potential of precision medicine

Juneau Biosciences presents new genetic discoveries in endometriosis at annual ASRM meeting

Early trial results in lung cancer

Psychiatric symptoms predate motor onset in Huntington’s disease

New study from TSRI and Salk points to cause of debilitating nerve disease

Ground-breaking discovery helps scientists view DNA damage with crystal clarity

Bioengineers develop continuously tunable method to find and quantify DNA, RNA biomarkers

Scientists reveal link between depression and paraventricular thalamus

Sequenom enters into clinical collaboration with CU School of Medicine

Breakthrough advancements on new molecular mechanism may lead to Parkinson's treatments

UB study sheds light on the root causes of Huntington's disease

UAMS researchers report positive results from treating Metastatic Merkel-cell carcinoma with idelalisib drug

Genetic mutation linked to ALS, FTD prevents proteins from entering and exiting the cell's nucleus

Camels in Kenya infected by MERS virus, new study finds

CNIO researchers identify molecular mechanisms that determine cancer predisposition in DBA patients

New zebrafish study provides insights into causes of congenital heart defects

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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