Cholesterol News and Research

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Cholesterol is a waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid.

Alnylam and Tekmira to collaborate on RNAi therapeutics

Alnylam Pharmaceuticals, Inc. and Tekmira Pharmaceuticals Corporation announced today that they will jointly participate in a new research collaboration focused on the discovery of novel cationic lipids and lipid nanoparticles for the systemic delivery of RNAi therapeutics.

6 Aug 2009

New insights into peripheral artery disease

Walking is a painful experience for many of the eight million Americans who suffer lower extremity peripheral arterial disease, or PAD. The condition, which is associated with aging and involves progressive functional decline, can cause heaviness, tightness, cramping or sharp pain in the calf muscle. Symptoms typically disappear with rest and return when walking resumes.

5 Aug 2009

Social stress linked to visceral fat, atherosclerosis

A new study done by researchers at Wake Forest University School of Medicine shows that social stress could be an important precursor to heart disease by causing the body to deposit more fat in the abdominal cavity, speeding the harmful buildup of plaque in blood vessels, a stepping stone to the number one cause of death in the world.

5 Aug 2009

Elevated cholesterol levels in midlife raises risk of late-life dementia

Elevated cholesterol levels in midlife - even levels considered only borderline elevated - significantly increase the risk of Alzheimer's disease and vascular dementia later in life, according to a new study by researchers at Kaiser Permanente's Division of Research and the University of Kuopio in Finland. The study appears in the journal Dementia & Geriatric Cognitive Disorders.

4 Aug 2009

FDA approves Livalo (pitavastatin), a new cholesterol-lowering drug

The U.S. Food and Drug Administration today approved the 4 milligram maximum dose of Livalo (pitavastatin), a drug intended to improve blood cholesterol levels in persons with elevated or abnormal blood cholesterol levels.

3 Aug 2009

Seven out of ten U.S. children low in vitamin D

Seven out of ten U.S. children have low levels of vitamin D, raising their risk of bone and heart disease, according to a study by researchers at Albert Einstein College of Medicine of Yeshiva University. The striking findings suggest that vitamin D deficiency could place millions of children at risk for high blood pressure and other risk factors for heart disease.

3 Aug 2009

Common food additive lecithin may help control blood lipids and reduce disease risk

Scientists at Washington University School of Medicine in St. Louis have identified a substance in the liver that helps process fat and glucose. That substance is a component of the common food additive lecithin, and researchers speculate it may one day be possible to use lecithin products to control blood lipids and reduce risk for diabetes, hypertension or cardiovascular disease using treatments delivered in food rather than medication.

31 Jul 2009

New chemical imaging technique could help in the fight against atherosclerosis

A new chemical imaging technique could one day help in the fight against atherosclerosis, suggests research published in the August 2009 edition of the Journal of the Royal Society Interface.

31 Jul 2009

Plenty of dairy foods in childhood may mean a longer life

Milk is an excellent source of calcium and the children who ate plenty of dairy foods such as milk and cheese appeared to be protected against stroke and other causes of death, even though dairy products often contain fats and cholesterol which fur up the arteries and high consumption of dairy products did not raise the heart disease risk.

28 Jul 2009

Coronary calcium scoring may predict heart attack risk

Researchers may be able to predict future severe cardiac events in patients with known, stable coronary artery disease (CAD) using coronary calcium scoring, according to a study published in the online edition of Radiology.

28 Jul 2009

Intensive glucose control halves complications of longstanding type 1 diabetes

Near-normal control of glucose beginning as soon as possible after diagnosis would greatly improve the long-term prognosis of type 1 diabetes, concludes a study published in the July 27, 2009, issue of the Archives of Internal Medicine, which updates information about the clinical course of type 1 diabetes.

27 Jul 2009

Diets high in calcium and dairy products in childhood may lower mortality

Suggestive evidence points to the possibility that children who have a diet high in calcium and who consume dairy products may have a lower mortality rate than those who don't, according to a study by researchers in Bristol and Brisbane, published in the journal Heart.

27 Jul 2009

Research reveals major genetic differences between blood and tissue cells

Research by a group of Montreal scientists calls into question one of the most basic assumptions of human genetics: that when it comes to DNA, every cell in the body is essentially identical to every other cell. Their results appear in the July issue of the journal Human Mutation.

15 Jul 2009

Research shows segments of carotid artery respond differently to atherosclerotic plaque buildup

Different segments of the carotid artery that supply the brain with blood respond in different fashions to the build-up of complex, health-threatening plaque, according to researchers from Wake Forest University Baptist Medical Center and their colleagues.

14 Jul 2009

New heart disease risk score outperforms existing test

An independent external validation of QRISK® - a new score for predicting a person's risk of heart disease - has shown that it performs better than the existing test and should be recommended for use in the United Kingdom by the National Institute for Health and Clinical Excellence (NICE).

9 Jul 2009

Health reform legislation will impact preventive and wellness programs

Reuters reports: "Efforts to overhaul the U.S. healthcare system and expand coverage to millions of uninsured could lead some wellness programs to expand and others to constrict, experts say.... In all of the bills in Congress, insurers would be required to cover some preventive services, and all of the bills include prevention and wellness incentives.

8 Jul 2009

Identification of cholesterol regulating genes by targeted RNAi-screening

Scientists at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany, have come a step closer to understanding how cholesterol levels are regulated. In a study published today in the journal Cell Metabolism, the researchers identified 20 genes that are involved in this process. Besides giving scientists a better idea of where to look to uncover the mechanisms that ensure cholesterol balance is maintained, the discovery could lead to new treatments for cholesterol-related diseases.

7 Jul 2009

The single life can increase some people's dementia risk

The researchers from the Karolinska Institute suggest that people who have a particular gene variation and live alone in middle-age, have a higher risk of developing dementia.

5 Jul 2009

Newly discovered gene regulates balance of 'bad' cholesterol

In an article in Science, Noam Zelcer from the LACDR describes a previously unknown mechanism for regulating the amount of LDL cholesterol. This offers opportunities for supplementing and improving the effect of so-called statins: medicines that remove 'bad' cholesterol from the bloodstream.

30 Jun 2009

Two studies on polycystic ovarian syndrome shed light on its causes and its effect on brothers of women with the condition

Researchers have found evidence that chronic disease in either a mother or father can create unfavourable conditions in the womb that are associated with the development of polycystic ovarian syndrome (PCOS) in daughters. In another study, researchers found that brothers of women with PCOS and insulin resistance are themselves at greater risk of developing insulin resistance or diabetes, suggesting that factors associated with the condition can be passed down to sons as well as daughters.

30 Jun 2009