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Biomolecular imaging: an interview with Professor Roger Reddel

The reason Children’s Medical Research Institute (CMRI) exists is to find ways to treat or prevent childhood disease. Our research programs are focussed on the areas of cancer cell growth, nerve cell signalling, embryology and gene therapy. These four programs have a shared aim of translating novel findings into new treatments for the benefit of families everywhere.

19 Nov 2012

Overexpression of BCL6 results in transformation of neural stem cells into cortical neurons

The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases.

19 Nov 2012

New nanoparticle halts relapsing remitting multiple sclerosis in mouse model

In a breakthrough for nanotechnology and multiple sclerosis, a biodegradable nanoparticle turns out to be the perfect vehicle to stealthily deliver an antigen that tricks the immune system into stopping its attack on myelin and halt a model of relapsing remitting multiple sclerosis (MS) in mice, according to new Northwestern Medicine research.

19 Nov 2012

NIH-funded scientists develop new treatment to combat autoimmune disorders in mouse model

In a mouse model of multiple sclerosis (MS), researchers funded by the National Institutes of Health have developed innovative technology to selectively inhibit the part of the immune system responsible for attacking myelin-the insulating material that encases nerve fibers and facilitates electrical communication between brain cells.

18 Nov 2012

Study shows how Parkinson's spreads and leads to nerve cell death

Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. Now, after several years of incremental study, researchers at the Perelman School of Medicine, University of Pennsylvania have been able to piece together important steps in how Parkinson's disease (PD) spreads from cell to cell and leads to nerve cell death.

17 Nov 2012

Scientists identify cell growth pathway that is unusually active in gliomas

Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.

17 Nov 2012

Hearing impairment risk high with diabetes

People with diabetes are at high risk for developing a hearing impairment, report researchers.

16 Nov 2012

Hearing impairment risk high with diabetes

People with diabetes are at high risk for developing a hearing impairment, report researchers.

15 Nov 2012

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

Myasthenia gravis (MG) is an autoimmune disease that produces weakness and fatiguability of muscles. It affects between 1 and 7 people per 10,000, according to the best statistics.

15 Nov 2012

Heart rate variability may help to understand chronic fatigue syndrome (CFS)

Researchers have discovered for the first time that reduced heart rate variability – or changes in heart beat timing – best predicts cognitive disturbances, such as concentration difficulties commonly reported by people with chronic fatigue syndrome (CFS).

15 Nov 2012

Brevetoxin-2 stimulates nerve cell growth and plasticity in cultured mouse neurons

A new study using brevetoxin-2, a compound produced naturally by marine algae, stimulated nerve cell growth and plasticity in cultured mouse neurons. This research advances a potentially new pharmacological treatment to aid recovery of brain function following a stroke or other traumatic brain injury.

14 Nov 2012

Study reveals how interneurons navigate during cerebral cortex development

As the brain develops, each neuron must find its way to precisely the right spot to weave the intricate network of links the brain needs to function. Like the wiring in a computer, a few misplaced connections can throw off functioning for an entire segment of the brain.

14 Nov 2012

Hearing impairment more prevalent among patients with diabetes

Patients with diabetes have a significantly higher prevalence of hearing impairment than patients without diabetes, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Study authors note that the finding is likely to be independent of the effect of aging or a noisy environment.

14 Nov 2012

Scientists discover how external signals regulate vascular remodelling at cell level

Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, the smooth muscle cells in blood vessels demonstrate a high degree of plasticity, so they can specialise or multiply as required, even repairing damage to the vessel wall.

13 Nov 2012

Novel electrotherapy reduces energy needed to re-establish normal rhythm in the heart

Implantable defibrillators currently on the market apply between 600 and 900 volts to the heart, almost 10 times the voltage from an electric outlet, says Ajit H. Janardhan, MD, PhD, a cardiac electrophysiology fellow at the Washington University's School of Medicine.

13 Nov 2012

University of Leicester scientists identify unique forms of spinal nerve activity

Scientists from the University of Leicester have hit upon unique forms of spinal nerve activity that shape output of nerve cell networks controlling motor behaviours.

9 Nov 2012

Mindful eating reduces weight and blood sugar levels in adults with Type 2 diabetes

Eating mindfully, or consuming food in response to physical cues of hunger and fullness, is just as effective as adhering to nutrition-based guidelines in reducing weight and blood sugar levels in adults with Type 2 diabetes, a new study suggests.

9 Nov 2012

Dopamine improves long-term memory

The feel-good hormone dopamine improves long-term memory. This is the finding of a team lead by Emrah D-zel, neuroscientist at the German Center for Neurodegenerative Diseases and the University of Magdeburg.

9 Nov 2012

UIC researchers develop transgenic Alzheimer's mouse with apoE4 gene

Researchers at the University of Illinois at Chicago College of Medicine have developed a transgenic mouse that carries a human gene known to increase risk of Alzheimer's 15-fold. This new mouse mimics the genetics of the human disease more closely than any of the dozen existing mouse models and may prove more useful in the development of candidate drugs to prevent or treat the disease.

9 Nov 2012

Synthetic cannabinoid could treat pain in diabetes patients

Oral synthetic cannabinoid nabilone may be effective for treating diabetic peripheral neuropathic pain, a study shows.

8 Nov 2012

Nerve News and Research

Biomolecular imaging: an interview with Professor Roger Reddel

Overexpression of BCL6 results in transformation of neural stem cells into cortical neurons

New nanoparticle halts relapsing remitting multiple sclerosis in mouse model

NIH-funded scientists develop new treatment to combat autoimmune disorders in mouse model

Study shows how Parkinson's spreads and leads to nerve cell death

Scientists identify cell growth pathway that is unusually active in gliomas

Hearing impairment risk high with diabetes

Hearing impairment risk high with diabetes

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

Heart rate variability may help to understand chronic fatigue syndrome (CFS)

Brevetoxin-2 stimulates nerve cell growth and plasticity in cultured mouse neurons

Study reveals how interneurons navigate during cerebral cortex development

Hearing impairment more prevalent among patients with diabetes

Scientists discover how external signals regulate vascular remodelling at cell level

Novel electrotherapy reduces energy needed to re-establish normal rhythm in the heart

University of Leicester scientists identify unique forms of spinal nerve activity

Mindful eating reduces weight and blood sugar levels in adults with Type 2 diabetes

Dopamine improves long-term memory

UIC researchers develop transgenic Alzheimer's mouse with apoE4 gene

Synthetic cannabinoid could treat pain in diabetes patients

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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