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Researchers locate specific mutation in the gene responsible for Chédiak-Higashi syndrome

Humans and animals are made up of trillions of cells, and each cell contains DNA specific to that individual. Therefore, identifying DNA that causes genetic disorders gives researchers and clinicians a better understanding of how to treat inherited diseases and possibly prevent the diseases from being passed down to future generations.

30 Jan 2020

Scientists track down a potential target for new sleeping sickness drugs

Using ultra-bright X-ray flashes, a team of researchers has tracked down a potential target for new drugs against sleeping sickness: The scientists have decoded the detailed spatial structure of a vital enzyme of the pathogen, the parasite Trypanosoma brucei.

30 Jan 2020

Increased brain growth, mutations and autism linked in new study

Salk Institute researchers have now found a pattern of DNA damage that is unique to brain cells derived from individuals with a single form of autism spectrum disorder (ASD) called macrocephalic ASD. The study, published in the journal Cell Stem Cell in January 2020, may offer an explanation about the developmental misstep that caused this disease.

30 Jan 2020

Gene-editing taken to advanced levels in human stem cells

A new study published in the journal Stem Cell Reports in January 2020 reports the use of an adaptation to a commonly used gene editing technology to achieve a more than 900% increase in efficiency.

30 Jan 2020

New genetic screen for Huntington’s disease

Huntington’s disease is a genetic disease that is debilitating and progressive leading to severe brain damage and eventual death. In patients with this autosomal dominant disease, there is presence of a protein called the Huntingtin protein that forms clumps within the brain leading to the symptoms of the disease.

30 Jan 2020

Wuhan coronavirus is genetically different from human SARS, MERS-CoV, study found

The Wuhan coronavirus or the 2019-nCoV or novel coronavirus is a new human-infecting coronavirus genetically different from human SARS (Severe Acute Respiratory Syndrome), and MERS-CoV (Middle East Respiratory Syndrome), a team of scientists has found.

30 Jan 2020

Study maps immune responses to tuberculosis across 3 species

Tuberculosis is one of the world's most vexing public health problems. About 1.5 million people died from this bacterial lung infection in 2018, and the World Health Organization estimates that one-quarter of the world's population -- some 2 billion people, mostly in developing countries -- are infected with the bacteria that causes TB.

30 Jan 2020

Death receptor pathway drives resistance to CAR T cell therapy

Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why.

30 Jan 2020

Study may help develop ibrutinib-based combination therapies for blood cancer

Chronic lymphocytic leukemia (CLL) is the most common form of blood cancer (leukemia) in the Western world, affecting approximately 1.2% of all cancer patients.

30 Jan 2020

Group A streptococcus strains that are less susceptible to commonly used antibiotics identified

Infectious disease scientists identified strains of group A streptococcus that are less susceptible to commonly used antibiotics, a sign that the germ causing strep throat and flesh-eating disease may be moving closer to resistance to penicillin and other related antibiotics known as beta-lactams.

30 Jan 2020

Study shows protective cells reduce lung cancer risk in ex-smokers

A new study could explain how lung cancer risk is reduced by quitting smoking. Published in the journal Nature in January 2020, the study shows that ex-smokers have a greater number of lung cells that have healthy genes compared to current smokers. Healthy genes are less likely to transform into cancerous cells.

29 Jan 2020

Japanese researchers identify genetic variations related to specific dietary habits

Researchers at the RIKEN Center for Integrative Medical Sciences in Japan and colleagues at Osaka University have found genetic variations in humans related to specific dietary habits.

29 Jan 2020

Inducing totipotency into stem cells opens new doors for potential cell replacement therapies

Early mammalian development is a highly complex process involving elaborate and highly coordinated biological processes.

29 Jan 2020

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.

29 Jan 2020

Bavarian research network aims to develop new approaches against multi-resistant pathogens

Developing fundamental new approaches against multi-resistant pathogens is the aim of the new Bavarian research network called New Strategies Against Multi-Resistant Pathogens by Means of Digital Networking - bayresq.net.

29 Jan 2020

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.

29 Jan 2020

Coronavirus spreads - Australian breakthrough

Novel coronavirus, temporarily named “2019-nCoV”, has affected over 4,600 persons across the world and is spreading at a rapid pace say experts. The World Health Organization and other health organizations have stepped up vigilance to detect and isolate the infection to contain outbreaks.

28 Jan 2020

Study on axolotl's ability to regenerate might help find ways to restore damaged tissue in humans

The type of salamander called axolotl, with its frilly gills and widely spaced eyes, looks like an alien and has other-worldly powers of regeneration. Lose a limb, part of the heart or even a large portion of its brain? No problem: They grow back.

28 Jan 2020

Holistic and data-driven health assessment can help achieve early disease detection

Human Longevity, Inc., an innovator in providing data-driven health intelligence and precision health to physicians and patients, announced today the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences.

27 Jan 2020

New gene correction therapy for hereditary muscular disease among children

Duchenne type muscular dystrophy is the most common hereditary muscular disease among children, leaving them wheelchair-bound before the age of twelve and reducing life expectancy.

27 Jan 2020

Genome News and Research

Researchers locate specific mutation in the gene responsible for Chédiak-Higashi syndrome

Scientists track down a potential target for new sleeping sickness drugs

Increased brain growth, mutations and autism linked in new study

Gene-editing taken to advanced levels in human stem cells

New genetic screen for Huntington’s disease

Wuhan coronavirus is genetically different from human SARS, MERS-CoV, study found

Study maps immune responses to tuberculosis across 3 species

Death receptor pathway drives resistance to CAR T cell therapy

Study may help develop ibrutinib-based combination therapies for blood cancer

Group A streptococcus strains that are less susceptible to commonly used antibiotics identified

Study shows protective cells reduce lung cancer risk in ex-smokers

Japanese researchers identify genetic variations related to specific dietary habits

Inducing totipotency into stem cells opens new doors for potential cell replacement therapies

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

Bavarian research network aims to develop new approaches against multi-resistant pathogens

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Coronavirus spreads - Australian breakthrough

Study on axolotl's ability to regenerate might help find ways to restore damaged tissue in humans

Holistic and data-driven health assessment can help achieve early disease detection

New gene correction therapy for hereditary muscular disease among children

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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