Amyotrophic Lateral Sclerosis News and Research

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Duke researchers discover potential cause for ALS syndromes using mouse models

A team of researchers at Duke University Medical Center led by Dr. Paulo Ferreira and whose work was supported by the National Institutes of Health has found that derailing the transport of certain receptors that carry cargoes from and to the nucleus of motor neurons causes motor neuron disease in mice.

1 Mar 2017

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

Implementation of a new nuclear magnetic resonance spectroscopy platform will provide professors Nicolas Doucet and Steven LaPlante of Centre INRS-Institut Armand-Frappier with a powerful new tool for conducting an ambitious research program aimed at identifying new therapeutic molecules.

28 Feb 2017

New test could accelerate development of better treatments for Motor Neuron Disease

A cutting-edge test developed in South Australia has the potential to expedite the worldwide quest to develop better treatments, or even a cure, for the Motor Neuron Disease (MND).

24 Feb 2017

Mindfulness-based meditation program improves quality of life and well-being in ALS patients

An eight-week mindfulness-based meditation program led to improved quality of life and psychological well-being in clinical trial of patients with amyotrophic lateral sclerosis.

23 Feb 2017

Targeting RNA repeats

RNA repeats are stretches of code in the body that incrementally repeat. For example, in the most common cause of adult-on-set muscular dystrophy a RNA has a repeat of r(CUG) and this three letter code can repeat thousands of times.

20 Feb 2017

New method that detects NMD efficiency could help in treatment of many diseases

In cells, DNA is first converted to RNA, and RNA is next converted to proteins--a complicated process involving several other steps. Nonsense-mediated RNA decay is a processing pathway in cells that, like a broom, cleans up erroneous RNA to prevent its productive conversion into an aberrant protein, which could lead to disease.

17 Feb 2017

Children of parents affected with C9orf72 mutations more likely to have FTD and ALS at younger age

The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene.

14 Feb 2017

Designer compound may be effective tool for tackling tau-related disorders

In a study of mice and monkeys, National Institutes of Health funded researchers showed that they could prevent and reverse some of the brain injury caused by the toxic form of a protein called tau.

8 Feb 2017

New technology enables “completely locked-in” patients to communicate

A brain─computer interface has enabled people with “locked-in” syndrome to communicate, according to trial results published in PLOS Biology. The device was able to decipher the thoughts of four patients who were unable to speak, move or blink and relay “yes” or “no” answers to basic questions.

2 Feb 2017

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

A computer interface that can decipher the thoughts of people who are unable to communicate could revolutionize the lives of those living with completely locked-in syndrome, according to a new paper publishing January 31st, 2017 in PLOS Biology.

1 Feb 2017

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

A bacterial by-product known to be important in maintaining gut health may slow the progression of amyotrophic lateral sclerosis, or ALS - a progressive, neurodegenerative disease.

27 Jan 2017

Researchers explore how eye muscles retain mobility in ALS patients

Amyotrophic Lateral Sclerosis, commonly known as ALS, is an incurable neurodegenerative disease that affects all voluntary muscles in the body leading to paralysis and breathing difficulties.

26 Jan 2017

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons. In some people, though, it collects into toxic tangles that damage brain cells.

25 Jan 2017

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Illumina, Inc. and Bio-Rad Laboratories, Inc. today announced the launch of the Illumina® Bio-Rad® Single-Cell Sequencing Solution at the J.P. Morgan Healthcare Conference. The comprehensive solution is the first next-generation sequencing (NGS) workflow for single-cell analysis, providing researchers the ability to investigate the coordinated contribution of individual cells in tissue function, disease progression, and therapeutic response.

From Illumina, Inc. 12 Jan 2017

Amyotrophic Lateral Sclerosis News and Research

Duke researchers discover potential cause for ALS syndromes using mouse models

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

New test could accelerate development of better treatments for Motor Neuron Disease

Mindfulness-based meditation program improves quality of life and well-being in ALS patients

Targeting RNA repeats

New method that detects NMD efficiency could help in treatment of many diseases

Children of parents affected with C9orf72 mutations more likely to have FTD and ALS at younger age

Designer compound may be effective tool for tackling tau-related disorders

New technology enables “completely locked-in” patients to communicate

Brain-computer interface could revolutionize lives of people with completely locked-in syndrome

Bacterial by-product helps correct gut microbiome imbalance in mouse model of ALS

Researchers explore how eye muscles retain mobility in ALS patients

Synthetic molecule appears to reverse Alzheimer's-related neurological damage

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Orphan Disease Center establishes new initiative that focuses on ALS

Study shows new role of zinc in optic nerve injury

New tool explains how proteins assemble into different liquid and gel-like solid states

New findings about key cellular protein could lead to treatments for neurodegenerative diseases

Scientists detail structure of molecule implicated in Alzheimer's disease

Researchers use microbubbles and ultrasound to transport drugs across blood–brain barrier

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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