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COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

A team of scientists from the United States has recently demonstrated that current coronavirus disease 2019 (COVID-19) vaccines induce robust spike-specific T cell responses against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

1 Feb 2022

Mix-and-match of COVID-19 vaccine boosters found to be safe and effective

In adults who had previously received a full regimen of a COVID-19 vaccine approved or authorized by the Food and Drug Administration (FDA), an additional dose of any of these COVID-19 vaccines was safe and prompted an immune response, according to study findings published Jan. 26 in The New England Journal of Medicine.

28 Jan 2022

Novel “prime and spike” vaccine strategy leverages existing immunity generated by primary COVID-19 vaccination

Scientists from Yale University, USA, have recently developed an intranasal spike boosting vaccine that induces robust mucosal immunity in the respiratory tract,

28 Jan 2022

Immuno-proteomic profiling suggests aberrant immune cell regulation associated with post-COVD-19 infection

A new study investigates the association between the immune system and respiratory complications post-COVID-19 infection.

28 Jan 2022

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

New research assesses the impact of mutations in SARS-CoV-2 variants of concern (VOCs) on the T lymphocytes, specifically to the spike (S) protein of SARS-CoV-2.

27 Jan 2022

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

A new study, published on the medRxiv preprint server, focused on the production of human CD4+ T cell lines (TCLs), reactive to either S or M protein, and analyzed if the S and M structural proteins had intrinsic differences in driving antigen-specific CD4+ T cell responses.

27 Jan 2022

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Researchers assess the probability of T-cell apoptosis in patients with severe COVID-19 who were admitted to the hospital.

26 Jan 2022

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

A new study assesses SARS-CoV-2 antigen-specific cytokine responses in a cohort of SARS-CoV-2 infected individuals with varying levels of disease.

26 Jan 2022

Homologous and heterologous COVID-19 booster vaccines found to be safe and immunogenic

In adults who had previously received a full regimen of any of three COVID-19 vaccines granted Emergency Use Authorization (EUA) or approved by the U.S. Food and Drug Administration, an additional booster dose of any of these vaccines was safe and prompted an immune response, according to preliminary clinical trial results reported in The New England Journal of Medicine.

26 Jan 2022

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

In a new study, researchers evaluated SARS-CoV-2 vaccination-induced T cell responses cross-recognition among the early and novel SARS-CoV-2 variants.

26 Jan 2022

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

In a new study, a team of researchers developed a vaccine candidate with the SARS-CoV-2 spike (S) glycoprotein coated onto lipid vesicles which resembles virus-like particles.

26 Jan 2022

SARS-CoV-2 infection and vaccination-induced T cells cross-recognize Omicron

In a recent study posted to the Nature In Review* preprint server, researchers performed a comprehensive, in-depth comparison of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell epitope repertoire following natural infection of coronavirus disease 2019 (COVID-19) compared to messenger ribonucleic acid (mRNA) vaccinations.

25 Jan 2022

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

A new study investigated SARS-CoV-2 spike protein responses targeted by cross-reactive T cells that were isolated from convalescent COVID-19 individuals along with previously uninfected donors.

25 Jan 2022

Current vaccines prompt the body to make effective, long-lasting T cells against SARS-CoV-2 variants

Scientists at La Jolla Institute for Immunology (LJI) have found that four COVID-19 vaccines (Pfizer-BioNTech, Moderna, J&J/Janssen, and Novavax) prompt the body to make effective, long-lasting T cells against SARS-CoV-2.

24 Jan 2022

Study finds stable T-Cell response against Omicron after mRNA booster vaccination

A new study measured T cell activity in vaccinated individuals and found a third vaccine provided substantial T-cell immunity against the Omicron variant of SARS-CoV-2.

24 Jan 2022

Novel SARS-CoV-2 mutations reported in chronic HIV patients

A new study describes the emergence of new SARS-CoV-2 variants in three immunocompromised patients.

23 Jan 2022

Research shows benefits of hybrid immunity to SARS-CoV-2

Researchers examine the effects of previous SARS-CoV-2 infections on the immunity offered by SARS-CoV-2 vaccination.

20 Jan 2022

Study finds Omicron infection effectively induces immunity against itself and enhances protection against other variants in vaccinated individuals

Researchers investigated the effectiveness of the SARS-CoV-2 Omicron-variant induced immunity, whether it is cross-protective against other variants, and if earlier infection with the SARS-CoV-2 Delta variant offers protection against Omicron.

20 Jan 2022

Study explores COVID-19 diagnosis and outcomes in HIV patients

In a new study, researchers determined the effect of the human immunodeficiency virus (HIV) on coronavirus disease 2019 (COVID-19) diagnosis and disease outcomes and compared to those without HIV.

19 Jan 2022

Study finds COVID booster maintains strong T cell response against Omicron

New study results posted to the medRxiv* preprint server found that COVID vaccine boosters increase immunity by enhancing T cell immune memory. In the face of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) Omicron variant, vaccinated people who had received a third booster shot maintained high T cell responses than people with naturally acquired immunity or vaccine-induced immunity from two doses of the SARS‑CoV‑2 vaccine.

18 Jan 2022

CD4 News and Research

COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

Mix-and-match of COVID-19 vaccine boosters found to be safe and effective

Novel “prime and spike” vaccine strategy leverages existing immunity generated by primary COVID-19 vaccination

Immuno-proteomic profiling suggests aberrant immune cell regulation associated with post-COVD-19 infection

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

Homologous and heterologous COVID-19 booster vaccines found to be safe and immunogenic

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

SARS-CoV-2 infection and vaccination-induced T cells cross-recognize Omicron

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

Current vaccines prompt the body to make effective, long-lasting T cells against SARS-CoV-2 variants

Study finds stable T-Cell response against Omicron after mRNA booster vaccination

Novel SARS-CoV-2 mutations reported in chronic HIV patients

Research shows benefits of hybrid immunity to SARS-CoV-2

Study finds Omicron infection effectively induces immunity against itself and enhances protection against other variants in vaccinated individuals

Study explores COVID-19 diagnosis and outcomes in HIV patients

Study finds COVID booster maintains strong T cell response against Omicron

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