Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

A multi-institutional international study led by scientists at The University of Texas MD Anderson Cancer Center has revealed new information about how molecules called long non-coding RNAs (lncRNA) interact with HIF-1, a signaling pathway that is overexpressed in many cancers. HIF-1 has been shown to regulate breast cancer progression.

12 Jan 2016

Study illuminates ways to better treat knee meniscus tears, other injuries

Fibrocartilage tissue in the knee is comprised of a more varied molecular structure than researchers previously appreciated, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania and the University of Delaware.

11 Jan 2016

New report raises questions about potential risks of chromium therapies

Chromium supplements are widely consumed for their antidiabetic activity as chromium(III) enhances the insulin sensitivity of cells. In particular, orthomolecular practitioners believe in the beneficial effects of providing the body with extra amounts of essential trace elements.

6 Jan 2016

Study lays foundation for better therapeutic strategies to halt progression of tissue degeneration

Injury and degeneration of fibro-cartilaginous tissues, such as the knee meniscus and the intervertebral disc, have significant socioeconomic and quality-of-life costs. But the development of effective treatment strategies to address pathologies in these load-bearing tissues has been hindered by a lack of understanding of the relationships between their structure and their function.

5 Jan 2016

New study describes STING protein's role in potential suppression of colorectal cancer

A new study published today by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine reports on a key finding about the immune system's response to tumor development following studies on colorectal cancer.

4 Jan 2016

Body can control pathogen-induced inflammatory response, find Georgia State researchers

The body can control inflammatory response triggered by invasions of microbial pathogens, such as bacteria and viruses, a discovery that could lead to the development of new therapeutic agents for uncontrolled inflammation, according to researchers at Georgia State University.

29 Dec 2015

MD Anderson study reveals MDSCs as likely target for developing prostate cancer treatments

Immune suppressor cells called MDSCs (myeloid-derived suppressor cells) may be important in developing treatments for advanced prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center.

22 Dec 2015

New mathematical models shed light on complex interactions of stem cell function in neural tissue

New research has shed light on the complex interactions of stem cell function and molecular diffusion in neural tissue, which may explain many phenomena from stem cell differentiation to the formation of the cortex of the brain. While researching new methods of reconstructing 3D neural tissue and neural pathways in the brain and spinal cord, Dr. Richard McMurtrey devised new mathematical approaches for understanding the concentration of nutrients within the 3D tissue constructs and how this could affect tissue growth.

22 Dec 2015

Scientists outline molecular blueprints of tiny cellular 'nanomachine'

Scientists have drawn up molecular blueprints of a tiny cellular ‘nanomachine’, whose evolution is an extraordinary feat of nature, by using one of the brightest X-ray sources on Earth.

21 Dec 2015

Research reveals genetic variants linked to treatment-related complications in children with blood diseases

Research to be presented today at the 57th American Society of Hematology Annual Meeting and Exposition reveals genetic variants that are associated with disease severity and treatment-related complications in children with blood diseases.

7 Dec 2015

Research findings may lead to potential therapeutic target for treating inflammatory bowel diseases

UT Southwestern Medical Center researchers have shown that a pathogen-sensing molecule plays a vital role in keeping gastrointestinal (GI) systems healthy.

20 Nov 2015

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

Scientists from the Virginia Tech Carilion Research Institute and clinicians from Carilion Clinic have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.

20 Nov 2015

Harnessing the brain's immune system to combat Alzheimer's disease

A new study appearing in the Journal of Neuroinflammation suggests that the brain's immune system could potentially be harnessed to help clear the amyloid plaques that are a hallmark of Alzheimer's disease.

5 Nov 2015

Salk scientists uncover enzyme responsible for suppressing deadly lung cancer

Scientists at the Salk Institute have uncovered a molecule whose mutation leads to the aggressive growth of a common and deadly type of lung cancer in humans.

3 Nov 2015

Researchers identify role of cGAS enzyme in autoimmune diseases

Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice, while inhibiting the same enzyme rescues them, UT Southwestern Medical Center researchers report.

28 Oct 2015

First computational method based on evolutionary principles developed to predict protein dynamics

Researchers from the Structural Biology Computational Group of the Spanish National Cancer Research Centre, led by Alfonso Valencia, in collaboration with a group headed by Francesco Gervasio at the University College London (UK), have developed the first computational method based on evolutionary principles to predict protein dynamics, which explains the changes in the shape or dimensional structure that they experience in order to interact with other compounds or speed up chemical reactions.

26 Oct 2015

Restoring memory in aging mice

A new study, led by scientists at The Scripps Research Institute (TSRI), the Veterans Affairs San Diego Healthcare System (VA) and University of California (UC) San Diego School of Medicine shows that increasing a crucial cholesterol-binding membrane protein in nerve cells (neurons) within the brain can improve learning and memory in aged mice.

22 Oct 2015

DelMar reports positive data from preclinical study of VAL-083 for treatment of ovarian cancer

DelMar Pharmaceuticals, Inc., a biopharmaceutical company focused on the development and commercialization of new cancer therapies, announced that yesterday it presented positive preclinical data demonstrating the promising potential of its lead product candidate VAL-083 (dianhydrogalactitol) as a treatment for ovarian cancer.

19 Oct 2015

Study shows why cancer anemia therapy stimulates tumor growth

Scientists have shown why a drug widely used to treat chemotherapy-induced anemia in ovarian and breast cancer patients also may shorten survival times in some patients by inadvertently stimulating tumor growth.

16 Oct 2015

Scientists create 3D image of key protein involved in blood and other cancer development

Scientists at the Walter and Eliza Hall Institute have created the first three-dimensional image of a key protein known to be involved in the development of blood and other cancers.

13 Oct 2015

Cell Signaling News and Research

Further Reading

MD Anderson-led study explores role of HIF-1 in triple-negative breast cancer

Study illuminates ways to better treat knee meniscus tears, other injuries

New report raises questions about potential risks of chromium therapies

Study lays foundation for better therapeutic strategies to halt progression of tissue degeneration

New study describes STING protein's role in potential suppression of colorectal cancer

Body can control pathogen-induced inflammatory response, find Georgia State researchers

MD Anderson study reveals MDSCs as likely target for developing prostate cancer treatments

New mathematical models shed light on complex interactions of stem cell function in neural tissue

Scientists outline molecular blueprints of tiny cellular 'nanomachine'

Research reveals genetic variants linked to treatment-related complications in children with blood diseases

Research findings may lead to potential therapeutic target for treating inflammatory bowel diseases

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

Harnessing the brain's immune system to combat Alzheimer's disease

Salk scientists uncover enzyme responsible for suppressing deadly lung cancer

Researchers identify role of cGAS enzyme in autoimmune diseases

First computational method based on evolutionary principles developed to predict protein dynamics

Restoring memory in aging mice

DelMar reports positive data from preclinical study of VAL-083 for treatment of ovarian cancer

Study shows why cancer anemia therapy stimulates tumor growth

Scientists create 3D image of key protein involved in blood and other cancer development

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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