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New T cell biomarker could be much-needed patient-selection tool for CAR T cell therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia don't respond to chimeric antigen receptor T cell therapy, and the answer is tied to how primed patients' immune systems are before the therapy is administered.

30 Apr 2018

Chronic inflammation in middle age may increase risk of frailty decades later

A study of nearly 6,000 Americans followed for 24 years from middle to late adulthood found that having chronic inflammation in middle age may be linked to an increased risk of frailty and overall poorer health decades later.

26 Apr 2018

Early life stress impacts how the sensory systems develop, review shows

Life needs stimulation. However, overstimulation can cause exhaustion and illness. During specific sensitive periods early in life, stress can even affect later mental health.

16 Apr 2018

Researchers discover how muscles regulate oxygen consumption

A new study by researchers from Karolinska Institutet shows that an enzyme called FIH determines how muscles consume oxygen. Without the enzyme, the need for oxygen increases during physical exercise. The finding is of potential significance to elite athletes, who have been found to have higher levels of FIH in their muscles than others.

3 Apr 2018

Preventing metabolic exhaustion in immune cells could enhance effects of immunotherapy

If you're an immune cell gearing up to fight cancer, you'd better eat your breakfast. The tumor microenvironment is a harsh place, and tumor cells are ready to wear you out.

6 Mar 2018

Study provides valuable insights to prevalence of burnout in neurosurgery residents

When it comes to workplace stress, even doctors aren't immune to its effects. For doctors training to become neurosurgeons, burnout is common, and certain workplace stressors -- like unrewarding mentor relationships, difficult coworkers and not getting enough exposure to the operating room -- can lead to it, according to a new study from the Keck School of Medicine of USC.

9 Feb 2018

Pretreatment improves outcomes in high-risk stage 3 melanoma, study shows

A pair of targeted therapies given before and after surgery for melanoma produced at least a six-fold increase in time to progression compared to standard-of-care surgery for patients with stage 3 disease, researchers at The University of Texas MD Anderson Cancer Center report in Lancet Oncology.

18 Jan 2018

Experts call for action to reduce burnout among kidney specialists

Kidney specialists face increasing work demands, high rates of burnout, and declining interest in nephrology as a career.

11 Jan 2018

Loyola Medicine expert provides guidance on how to keep children safe from flu

Just as children are heading back to school after the winter break, the flu season has arrived. Loyola Medicine pediatrician Bridget Boyd, MD, has some advice for parents on how to help their child fend off the flu and what to do if they do get sick.

9 Jan 2018

Poor oral health contributes to frailty in older adults

Oral health issues are common among older adults. These issues include tooth loss, gum disease, tooth decay, and dry mouth.

4 Jan 2018

Child's attention and memory improves after exercising at own pace

A child's attention and memory improves after exercise according to new research conducted by primary school pupils and supported by the Universities of Stirling and Edinburgh.

19 Dec 2017

Study finds improvement in men’s health and negative health trend among women

Researchers at Umeå University and Region Norrbotten in Sweden have studied health trends among women and men aged 25-34 from 1990-2014. In 1990, 8.5 percent of women self-rated their health as being worse than peers in their own age group.

22 Nov 2017

Stress experienced by emergency call handlers has negative impact on psychological health

The stress experienced by emergency call handlers negatively impacts on their long term psychological wellbeing, a new report in the journal PeerJ reports.

14 Nov 2017

Researchers find distinct molecular signatures in chronic fatigue syndrome and Gulf War Illness

Researchers at Georgetown University Medical Center have found distinct molecular signatures in two brain disorders long thought to be psychological in origin -- chronic fatigue syndrome (CFS) and Gulf War Illness (GWI).

10 Nov 2017

Study: Many patients change their behaviors after suffering repeated bouts of C. diff infections

After suffering repeated bouts of debilitating Clostridium difficile infections, many patients significantly change their behaviors, but some precautions may do little to prevent future infections, according to a first-of-its-kind study.

8 Nov 2017

Study findings provide new insight into inflammatory bowel disease

Findings from a study into Crohn's disease, led by William G. Kerr, Ph.D., of SUNY Upstate Medical University, and his collaborators at the Erasmus Medical Center in the Netherlands, provide the first evidence that patients with debilitating inflammatory bowel disease lack sufficient quantities of a protein that comes from the SHIP1 gene.

6 Oct 2017

Exercising for just one hour a week can prevent depression, study finds

The Black Dog Institute has published a study showing that regular exercise can protect against depression, even if it is just for one hour a week.

3 Oct 2017

Cancer vaccines need to target immune fighters that can withstand battle against malicious tumors

Cancer vaccines may need to better target T cells that can hold up to the long fight against cancer, scientists report.

27 Sep 2017

Cyclists perform better in open-ended laboratory tests, study finds

Scientists at the University of Kent's School of Sport and Exercise Sciences have discovered that cyclists can perform better when they do not have to pace their efforts.

26 Sep 2017

Novel technology holds promise for improving accuracy of type 1 diabetes tests

Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy of diagnostic tests for type 1 diabetes in young children and making populationwide screening practical.

13 Sep 2017