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Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Study explores interplay between bone, adrenal glands, and aging

Figuring out how the tissues in our bones, adrenal glands, muscle and fat "talk" to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.

1 Aug 2024

Vegan diet may slow aging

Vegan diets showed short-term benefits on epigenetic aging compared to omnivorous diets in healthy twins, with reduced epigenetic age metrics observed in the vegan group. However, telomere length and overall mitotic clock values remained unchanged for both diets.

31 Jul 2024

Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways.

30 Jul 2024

Researchers to trial ground-breaking screening test for pre-eclampsia

Researchers are to trial a ground-breaking screening test for pre-eclampsia, a potentially life-threatening condition affecting pregnant women and their unborn babies.

29 Jul 2024

GLP-1-based polyagonists: A promising weight loss alternative to bariatric surgery

Researchers highlight the unprecedented success of GLP-1-based multi-receptor drugs in achieving substantial weight loss and improved health outcomes, potentially replacing bariatric surgery for obesity treatment.

28 Jul 2024

Could a Mediterranean diet be the secret to avoiding gestational diabetes?

The Mediterranean diet significantly reduces the risk of gestational diabetes mellitus (GDM) according to a new systematic review and meta-analysis. Higher adherence to this diet correlates with lower GDM incidence.

25 Jul 2024

LGBTIQ+ and cisgender heterosexual individuals exhibit more stress hormones during controversial campaign

How did the 2021 national marriage equality referendum campaign in Switzerland affect the well-being of the LGBTIQ+ community?

24 Jul 2024

Associations between gut microbes and Alzheimer’s disease

Researchers reviewed existing data on the role of the gut microbiome in Alzheimer’s disease (AD) pathogenesis.

24 Jul 2024

New study sheds light on irregular heartbeat risk

Two new, basic animal research studies shed light on alcohol consumption and the heart. The first study may help explain why binge drinking sometimes causes an irregular heartbeat and a possible way to prevent it. The second study investigated why alcohol may have a negative impact on heart function in women taking estrogen replacement therapy.

23 Jul 2024

Study reveals reduced type 1 diabetes risk in post-10-year-old girls

New research presented at this year's Annual Meeting of the European Association for Study of Diabetes (Madrid, Spain, 9-13 September) shows that the risk of developing type 1 diabetes (T1D) decreases markedly in girls after age 10 years, while the risk in boys stays the same.

22 Jul 2024

Studies aim to identify adolescent girls who are at risk of developing migraine headaches

A migraine is not just a bad headache. It is a much-dreaded part of a neurologic disorder that has an array of possible symptoms, including pulsating cranial pain, waves of queasiness, bouts of vomiting, and hypersensitivity to light and sound.

22 Jul 2024

Unraveling the rhythmic gene expression in legume-rhizobia symbiosis

Legumes thrive in low-nitrogen environments by partnering with rhizobia, soil bacteria that convert atmospheric nitrogen into ammonium, a usable form for the plants.

19 Jul 2024

Study links circadian rhythm disruption to obesity and diabetes

Disruption of circadian rhythms and clock gene expression is linked to adverse metabolic health outcomes, including obesity and diabetes. Further research is needed to understand these relationships and their implications for treatment and prevention.

17 Jul 2024