Metabolic Disorders News and Research

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30-year study of MSUD highlights critical need for more effective disease-modifying therapies

A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup Urine Disease (MSUD), which is among the most volatile and dangerous inherited metabolic disorders.

24 Jan 2020

Children born to mothers with gestational diabetes and preeclampsia at risk for higher BMI

Childhood obesity is a growing problem in the United States. For children, obesity is defined as having a body mass index at or above the 95th percentile, and according to the Centers for Disease Control and Prevention, 18.5% of children between the ages of 2 and 19 meet this criteria.

22 Jan 2020

Genes determining the browning of white fat finds study

The fat cells of the body play an essential role in the storage of energy and its release when necessary. Research has shown that apart from energy storage, these adipocytes or fat cells also play a role in hormonal balance and metabolism-regulating hunger. A new study titled, “Systems-genetics-based inference of a core regulatory network underlying white fat browning”, was published in the latest issue of the journal Cell Report.

13 Jan 2020

Researchers discover genes that could explain the Browning ability of white fat

Our fat cells, technically referred to as adipocytes, play an essential role in regulating energy balance in our body.

9 Jan 2020

Caffeine may offset some negative health effects of obesogenic diet

A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing the storage of lipids in fat cells and limiting weight gain and the production of triglycerides.

19 Dec 2019

High fat diet limits birth and development of new neurons in female mice

A high fat diet limits the birth and growth of new neurons in adult female, but not male, mice, according to new research published in eNeuro. Further research could inspire metabolism-based preventions and treatments for brain disorders.

From Society for Neuroscience 18 Dec 2019

High-fat meal can silence gut's communication with the body, study shows

A high-fat meal can silence communication between the intestine and the rest of the body, according to a new Duke University study in zebrafish.

17 Dec 2019

Perinatal exposure of rats to flame retardants changes the liver epigenome

Studies have shown that perinatal exposure of rats and mice to common flame retardants found in household items permanently reprograms liver metabolism, often leading later in life to insulin resistance and non-alcoholic fatty liver disease.

13 Dec 2019

Scientists develop an approach to vaccinate against gut inflammation

Inflammatory bowel disease (IBD) is an umbrella term that describes many disorders that involve chronic inflammation of the digestive tract, including ulcerative colitis and Crohn's disease. These conditions are tied to certain alternations in the gut flora.

12 Dec 2019

Researchers test vaccine strategy for chronic inflammatory diseases

Chronic inflammatory bowel diseases, such as Crohn's Disease and ulcerative colitis, are linked to abnormalities of the gut microbiota in humans and in animals. Patients generally present reduced bacterial diversity in their intestinal flora along with excessive levels of bacteria that express a protein called flagellin, which favors their mobility.

11 Dec 2019

Time-restricted eating can help treat metabolic syndrome

Metabolic syndrome affects nearly 30 percent of the U.S. population, and increases the risk for type 2 diabetes, heart disease and stroke. But lifestyle interventions such as adopting a healthy diet and increasing physical exercise are difficult to maintain and, even when combined with medication, are often insufficient to fully manage the disease.

5 Dec 2019

Study finds major sex differences when considering link between psoriasis and metabolic disorders

An analysis published in the Journal of the European Academy of Dermatology and Venereology revealed considerable sex differences when considering links between psoriasis and metabolic disorders.

4 Dec 2019

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

Daughters of women with polycystic ovarian syndrome are five times more likely to be diagnosed with PCOS as adults, and the generational transmission is driven by high androgen levels during pregnancy, researchers at Karolinska Institutet in Sweden report.

2 Dec 2019

Hibernators reveal genetic clues to better understand and treat obesity, metabolic disorders

Hibernation is one of nature's strangest quirks, inducing bears and other mammals to pack on massive weight- amounts that would be unhealthy for humans - so they can survive months of slumber. Yet when these animals reemerge, they are as fit as ever.

27 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Studying the genomes of hibernating mammals could improve understanding and treatment of obesity

A discovery about mammalian genomes and hibernation could aid understanding and treatment of obesity and metabolic disorders.

26 Nov 2019

Recently discovered protein may play key role in obesity and metabolic disease

With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism.

21 Nov 2019

Six world-class research teams to focus towards new frontiers in metabolism

The Azrieli Foundation, the Canadian Institutes of Health Research, the International Development Research Centre, and the Israel Science Foundation are pleased to announce the recipients of the Joint Canada-Israel Health Research Program's 5th call for proposals.

18 Nov 2019

Stress affects circadian rhythm, increases metabolic disease risk

Stress is a normal part of life, but too much of everything isn’t healthy. Every day, people from all walks of life experience stress of various degrees. A new study found that when stress has disrupted the circadian rhythm, the body’s internal clock, it can increase the risk of developing metabolic diseases.

12 Nov 2019

New textbook on mysterious and deadly cytokine storm syndrome

There's no telling where the call will come from, or when. But Randy Cron, M.D., Ph.D., professor of pediatrics and medicine at UAB, knows to expect them.

11 Nov 2019