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Corticosteroids decrease treatment failure among patients with community-acquired pneumonia

Among patients with severe community-acquired pneumonia and high initial inflammatory response, the use of the corticosteroid methylprednisolone decreased treatment failure, compared with placebo, according to a study in the February 17 issue of JAMA.

18 Feb 2015

Cabazitaxel therapy may be more effective in treating prostate cancer

Prostate cancer is the second leading cause of cancer for men in the United States. Only one class of chemotherapy called taxanes is effective against the disease.

17 Feb 2015

Study shows link between autoimmune diseases and gene regulatory elements

Investigators with the National Institutes of Health have discovered the genomic switches of a blood cell key to regulating the human immune system.

17 Feb 2015

Scientists demonstrate the importance of RNA editing in melanoma development

The importance of RNA editing in melanoma has been demonstrated by scientists at The University of Texas MD Anderson Cancer Center. The study revealed that a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.

17 Feb 2015

20th annual edition of NCCN Guidelines for Breast Cancer published

Breast cancer is the most frequently diagnosed cancer globally and the leading cause of cancer-related death in women. However, the incidence of breast cancer has somewhat stabilized over the past few decades, and breast cancer mortality appears to be declining, suggesting a benefit from the combination of early detection and more effective treatment.

16 Feb 2015

Study shows that de novo mutations can be detected in human in vitro fertilized embryos using PGD

Reprogenetics, the largest U.S. genetics laboratory specializing in Preimplantation Genetic Diagnosis (PGD), announced today the publication of new clinical data in the March issue of Genome Research demonstrating that de novo single base mutations can be detected in embryos after in vitro fertilization (IVF).

16 Feb 2015

Consortium formed to develop program to improve health outcomes for Ebola patients

Scripps Translational Science Institute will lead a consortium of four partners to develop a program through which wearable, wireless health sensors, a wireless vital signs monitoring platform and advanced analytics technology will be tested in a new "precision medicine" approach designed to improve health outcomes for Ebola patients, increase the safety of health care workers and reduce risk of spreading the virus to others.

16 Feb 2015

A*STAR's GIS scientists develop new system that can predict treatment targets for cancer

In recent months, several national initiatives for personalized medicine have been announced, including the recently launched precision medicine initiative in the US, driven by rapid advances in genomic technologies and with the promise of cheaper and better healthcare. Significant challenges remain, however, in the management and analysis of genetic information and their integration with patient data.

15 Feb 2015

Researchers identify molecular pathways associated with distinct subsets of SSc patients

For years, doctors have been baffled about why some patients with systemic sclerosis (SSc) respond to therapy while others do not.

12 Feb 2015

Rare and classic EGFR mutations have different impacts on NSCLC outcome

Certain rare epidermal growth factor receptor (EGFR) mutations are associated with tobacco smoking, worse prognosis and poor response to EGFR tyrosine kinase inhibitor (TKI) therapy compared to the more common "classical" EGFR mutations.

12 Feb 2015

Single genomic change can make beneficial bacteria into pathogenic bacteria

We, as most animals, host many different beneficial bacteria. Being beneficial to the host often pays off for the bacteria, as success of the host determines the survival and spread of the microbe. But if bacteria grow too much they may become deadly.

11 Feb 2015

GenomeDx announces publication of positive validation study for Decipher Prostate Cancer Classifier

GenomeDx Biosciences today announced the publication of a positive validation study for the Decipher® Prostate Cancer Classifier, a genomic test for prostate cancer. The study, published in the Journal of Clinical Oncology, showed that patients with low genomic risk (as determined by Decipher) may be optimally managed with observation after radical prostatectomy (prostate surgery), while those with high genomic risk (as determined by Decipher) may be better managed earlier with adjuvant radiotherapy.

10 Feb 2015

Quest Diagnostics, Myriad Genetics reach agreement to end BRCA gene-patent litigation

Quest Diagnostics, the world's leading provider of diagnostic information services, today announced that it and Myriad Genetics Inc. have reached an agreement that ends their BRCA gene-patent litigation.

From Quest Diagnostics 10 Feb 2015

Roche announces acquisition of Signature Diagnostics

Roche announced today the acquisition of Signature Diagnostics AG, a privately held company based in Potsdam, Germany. Signature is a translational oncology and genomics company that develops large blood plasma and tissue biobanks in multiple cancers, including colorectal and lung, which are constructed from multicenter prospective clinical studies.

From Roche Sequencing and Life Science 10 Feb 2015

Researchers develop quality assurance tool for genome editing

A research team at Boston Children's Hospital's Program in Cellular and Molecular Medicine has developed a quality assurance tool for scientists using genome-editing technologies like the increasingly popular CRISPR. The assay, called high throughput genome translocation sequencing (HTGTS), rapidly gauges—for any given gene—these technologies' accuracy and their risk for causing potentially dangerous genomic collateral damage.

9 Feb 2015

Research finding could help predict the next outbreak of plague

Biologists at the University of Oslo, Norway, are now making a giant effort to identify the relationship between climate change, rat infestations, and the many major plague epidemics throughout history. The knowledge may be used to predict the next plague outbreak.

9 Feb 2015

Preclinical testing of anti-Ebola antibodies can lead to universal flu vaccine

Does the blood of Ebola virus disease survivors contain antibodies and immune cells that could help doctors fight Ebola infections in other people?

9 Feb 2015

Leading medical societies jointly release new statement on using carrier screening in reproductive medicine

Carrier screening for inherited genetic disorders is an important part of preconception and prenatal care for the nearly 4 million women who give birth in the US annually. Carrier screening is meant to identify couples at risk for passing on such genetic conditions to their children.

9 Feb 2015

ECOG-ACRIN Cancer Research Group opens clinical trial for women with newly diagnosed DCIS

In direct response to recommendations made by a National Institutes of Health scientific consensus panel, the ECOG-ACRIN Cancer Research Group announced today the opening of E4112, a clinical trial for women with newly diagnosed ductal carcinoma in situ (DCIS) of the breast who, together with their doctors, will use the results of a magnetic resonance imaging (MRI) exam to determine whether to undergo a lumpectomy or a mastectomy.

6 Feb 2015

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Scientists at The Scripps Research Institute have found diverse genomic changes in single neurons from the brains of Alzheimer's patients, pointing to an unexpected factor that may underpin the most common form of the disease.

5 Feb 2015

Genomic News and Research

Corticosteroids decrease treatment failure among patients with community-acquired pneumonia

Cabazitaxel therapy may be more effective in treating prostate cancer

Study shows link between autoimmune diseases and gene regulatory elements

Scientists demonstrate the importance of RNA editing in melanoma development

20th annual edition of NCCN Guidelines for Breast Cancer published

Study shows that de novo mutations can be detected in human in vitro fertilized embryos using PGD

Consortium formed to develop program to improve health outcomes for Ebola patients

A*STAR's GIS scientists develop new system that can predict treatment targets for cancer

Researchers identify molecular pathways associated with distinct subsets of SSc patients

Rare and classic EGFR mutations have different impacts on NSCLC outcome

Single genomic change can make beneficial bacteria into pathogenic bacteria

GenomeDx announces publication of positive validation study for Decipher Prostate Cancer Classifier

Quest Diagnostics, Myriad Genetics reach agreement to end BRCA gene-patent litigation

Roche announces acquisition of Signature Diagnostics

Researchers develop quality assurance tool for genome editing

Research finding could help predict the next outbreak of plague

Preclinical testing of anti-Ebola antibodies can lead to universal flu vaccine

Leading medical societies jointly release new statement on using carrier screening in reproductive medicine

ECOG-ACRIN Cancer Research Group opens clinical trial for women with newly diagnosed DCIS

Alzheimer's brains commonly have many neurons with more DNA and genomic copies of APP gene

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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