Efficacy News and Research

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Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques

A new study describes the partial protection against respiratory infection with SARS-CoV-2 following gut inoculation with a live attenuated virus.

16 Sep 2021

Novel combination therapy approach to keep leukemia at bay

In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients' symptoms, but cannot truly change the course of the disease.

16 Sep 2021

New modeling on efficacy of BioNTech-Pfizer's SARS-CoV-2 vaccine against variants

In order to address these issues, scientists from Xitific LTD and IDEAPharma in the UK proposed a novel approach to the framework of immune correlates, built upon the previous research. The framework formulated by the authors was developed for the mRNA-based vaccinations but could be applied to the other variations.

16 Sep 2021

Therapeutic potential of clinical-grade ACE2 for blocking SARS-CoV-2 variants

According to new research by an international team of scientists, all SARS-CoV-2 variants, including variants of concern (VOC) Alpha, Beta, Gamma, and Delta, exhibit enhanced affinity toward recombinant human soluble ACE2.

16 Sep 2021

Scientists develop predictive computer model to alert surges in COVID-19 infections and mortalities

A team of scientists from Nanyang Technological University, Singapore (NTU Singapore) has developed a predictive computer model that, when tested on real pandemic data, proposed strategies that would have reduced the rate of both COVID-19 infections and deaths by an average of 72 percent, based on a sample from four countries.

16 Sep 2021

Grants to promote COVID-19 vaccination among people with intellectual and developmental disabilities

Patients with intellectual and developmental disabilities (IDD) are three times more likely to die from COVID-19 than the general population. Their heightened risk is due to a variety of causes: pre-existing health conditions, such as respiratory problems or obesity; increased likelihood of living in group homes, taking shared transportation, and being exposed to people outside their households; and struggles with safety precautions like mask-wearing or social distancing.

16 Sep 2021

Study looks at exposure to different SARS-CoV-2 variants and immune response

Researchers compared the responses against several SARS-CoV-2 VoCs in sera from individuals exposed to variant infection, vaccination, or both.

15 Sep 2021

COVID mRNA vaccines display weakened immune response with age and diminish over time, according to new study

Researchers from Simon Fraser University in Canada decided to investigate the magnitude of immunity in mRNA vaccines for COVID-19.

15 Sep 2021

Natural SARS-CoV-2 infection induces more durable immunity than vaccination study suggests

Scientists from the USA have demonstrated that immunity induced by mRNA-based COVID-19 vaccines in previously SARS-CoV-2-infected people has the highest robustness and durability with cross-reactivity against different viral variants.

15 Sep 2021

Vaccination of children before school reopening may control COVID-19 pandemic

A team has recently explored the impact of non-pharmaceutical control measures and vaccination on the COVID-19 pandemic during school reopening in England.

15 Sep 2021

A sweet pill to swallow: oral nucleoside analog of Remdesivir improved SARS-CoV-2 pathogenesis in mice

A new study focused on in vitro antiviral activity in various cell models and in vivo therapeutic efficacy of oral GS-621763 in a mouse model of SARS-CoV-2 pathogenesis.

15 Sep 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Study highlights need to accelerate COVID-19 vaccination in the U.S.

Researchers in the United States have warned that as of July 15th this year (2021), the level of population immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – may still have been insufficient to contain infection outbreaks and safely return to pre-pandemic social behavior.

15 Sep 2021

Prior symptomatic COVID-19 enhances mRNA vaccine response

A new paper describes the antibody responses in people who have already been infected with SARS-CoV-2 and are vaccinated as compared to the naïve.

14 Sep 2021

Study explains confounding effects of different dosages and dosing protocols on COVID-19 vaccine efficacies

A recent study investigates the paradoxical effects of dosage and dosing interval on COVID-19 vaccine efficacy.

14 Sep 2021

mRNA BNT162b2 vaccine safe in immunocompromised patients

The clinical trial showed that about 72.2% of immunocompromised patients had detectable antibodies against SARS-CoV-2.

14 Sep 2021

How effective are COVID-19 vaccines against mild and severe disease?

A new paper in the New England Journal of Medicine reports on the effectiveness of the COVID-19 vaccines in a healthcare setting.

14 Sep 2021

Effectiveness of mRNA-1273 against asymptomatic infection, COVID-19 diagnosis, and severe outcomes

A Moderna phase 3 trial provides evidence that the RNA-1273 vaccine is highly effective in preventing disease following infection SARS-CoV-2.

14 Sep 2021

SARS-CoV-2 infections surged in England this summer, despite high vaccine uptake

Researchers in the UK have warned that England experienced a rapid exponential increase this summer in the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – despite high rates of vaccination uptake.

14 Sep 2021

A review of mesenchymal stem cell therapy for severe COVID-19

Researchers find that MSC treatment is highly tolerated and effective in reducing lung damage in COVID-19 patients and improving their chances of recovery.

13 Sep 2021

Efficacy News and Research

Live oral SARS-CoV-2 vaccine provides partial protection in Rhesus Macaques

Novel combination therapy approach to keep leukemia at bay

New modeling on efficacy of BioNTech-Pfizer's SARS-CoV-2 vaccine against variants

Therapeutic potential of clinical-grade ACE2 for blocking SARS-CoV-2 variants

Scientists develop predictive computer model to alert surges in COVID-19 infections and mortalities

Grants to promote COVID-19 vaccination among people with intellectual and developmental disabilities

Study looks at exposure to different SARS-CoV-2 variants and immune response

COVID mRNA vaccines display weakened immune response with age and diminish over time, according to new study

Natural SARS-CoV-2 infection induces more durable immunity than vaccination study suggests

Vaccination of children before school reopening may control COVID-19 pandemic

A sweet pill to swallow: oral nucleoside analog of Remdesivir improved SARS-CoV-2 pathogenesis in mice

Drug accumulation alters gut bacterial metabolism and composition

Study highlights need to accelerate COVID-19 vaccination in the U.S.

Prior symptomatic COVID-19 enhances mRNA vaccine response

Study explains confounding effects of different dosages and dosing protocols on COVID-19 vaccine efficacies

mRNA BNT162b2 vaccine safe in immunocompromised patients

How effective are COVID-19 vaccines against mild and severe disease?

Effectiveness of mRNA-1273 against asymptomatic infection, COVID-19 diagnosis, and severe outcomes

SARS-CoV-2 infections surged in England this summer, despite high vaccine uptake

A review of mesenchymal stem cell therapy for severe COVID-19

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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