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Study: Long-term endurance training alters epigenetic pattern in the human skeletal muscle

A new study from Karolinska Institutet in Sweden shows that long-term endurance training in a stable way alters the epigenetic pattern in the human skeletal muscle. The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation.

10 Dec 2014

Researchers test new nanopore DNA sequencing technology to detect cause of antibiotic resistance

New nanopore DNA sequencing technology on a device the size of a USB stick could be used to diagnose infection - according to new research from the University of East Anglia and Public Health England.

From Oxford Nanopore Technologies 9 Dec 2014

Case Western Reserve selected to lead $27.3 million international effort to identify causes of SUDEP

Case Western Reserve is one of two universities in the country selected to lead a $27.3 million international effort to identify the causes of a mysterious and deadly phenomenon that strikes people with epilepsy without warning.

9 Dec 2014

Most parents interested in newborn genomic testing, study reveals

A study published this week in Genetics in Medicine is the first to explore new parents' attitudes toward newborn genomic testing. The findings suggest that if newborn genomic testing becomes available, there would be robust interest among new parents, regardless of their demographic background.

5 Dec 2014

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

The Multiple Myeloma Research Foundation announced today that new data from the landmark CoMMpass Study is now available to researchers via the MMRF's Researcher Gateway, an online, open-access portal designed to make key genomic and clinical data publically available for additional study.

5 Dec 2014

Scientists uphold mouse model of human disease, but pinpoint vital differences in gene expression

Scientists at Penn State College of Medicine, working alongside an international team of researchers, have produced the most complete encyclopedia of functional elements in the mouse genome to date and compared it to the human genome.

5 Dec 2014

Researchers publish first comprehensive characterization of genetic diversity in Sub-Saharan Africa

Researchers from the African Genome Variation Project have published the first attempt to comprehensively characterise genetic diversity across Sub-Saharan Africa. The study of the world's most genetically diverse region will provide an invaluable resource for medical researchers and provides insights into population movements over thousands of years of African history.

4 Dec 2014

University of Chicago collaborates with NCI to set up Genomic Data Commons

The University of Chicago is collaborating with the National Cancer Institute to establish the nation's most comprehensive computational facility that stores and harmonizes cancer genomic data generated through NCI-funded research programs.

3 Dec 2014

Maternal age and successful egg freezing with PGS: an interview with Dr. Santiago Munné

The leading cause of of pregnancy loss or infertility is chromosomal abnormality or imbalance, where extra genetic material is present or some is missing - what’s called aneuploidy. This imbalance leads to the inability to produce viable embryos or pregnancy.

2 Dec 2014

Researchers explore how to turn on the activity of paternal gene

Most genes are inherited as two working copies, one from the mother and one from the father. However, in a few instances, a gene is imprinted, which means that one copy is silenced. This is called genomic imprinting. If the active copy is mutated, then disease results, even though the silenced gene copy may be normal.

2 Dec 2014

CCR5 receptor plays key role in driving prostate cancer metastases

Although prostate cancer can be successfully treated in many men, when the disease metastasizes to the bone, it is eventually lethal. In a study published online December 1st in the journal Cancer Research, researchers show that the receptor CCR5 best known for its role in HIV therapy, may also be involved in driving the spread of prostate cancer to the bone.

1 Dec 2014

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

One of the main obstacles to finding effective therapies for human diseases has been our limited understanding of disease pathogenesis: we lack detailed knowledge of the cellular and molecular mechanisms that lead to the development of disease.

30 Nov 2014

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Researchers at the Center for iPS Cell Research and Application, Kyoto University, show that induced pluripotent stem (iPS) cells can be used to correct genetic mutations that cause Duchenne muscular dystrophy (DMD).

27 Nov 2014

Researchers uncover easily detectable, 'pre-malignant' state in the blood

Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, and Harvard-affiliated hospitals have uncovered an easily detectable, "pre-malignant" state in the blood that significantly increases the likelihood that an individual will go on to develop blood cancers such as leukemia, lymphoma, or myelodysplastic syndrome.

27 Nov 2014

Genom Austria project to explore impact of genome sequencing on science and society

In many countries, genome sequencing technology is now starting to become available in the clinic, where it helps to diagnose rare Mendelian diseases and contributes to personalized cancer therapy. The analysis of personal genomes also creates unprecedented opportunities for predictive health counseling, ancestry research, and many more applications that are just starting to emerge.

26 Nov 2014

Researchers discover two common genetic variants associated with memory performance

In the largest study of the genetics of memory ever undertaken, an international researcher team including scientists from Boston University School of Medicine, have discovered two common genetic variants that are believed to be associated with memory performance.

25 Nov 2014

Researchers examine genomic landscapes of humans and mice

Looking across evolutionary time and the genomic landscapes of humans and mice, an international group of researchers has found powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress response - are so different from those in people. Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

23 Nov 2014

Researchers explore new ways to treat, prevent Streptococcus pneumoniae

Scientists from Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology have used the power of new genomic technology to discover that microbes that commonly infect the eye have special, previously unknown properties. These properties are predicted to allow the bacterium -- Streptococcus pneumoniae -- to specifically stick to the surface of the eye, grow, and cause damage and inflammation.

13 Nov 2014

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease. The findings resulted from two separate studies published in the peer-reviewed journal PLoS ONE and based on data from The Cancer Genome Atlas (TCGA), the world's largest public database on gene expression in different tumor types.

12 Nov 2014

Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

A diagnostic test based on chromosomal rearrangements can trace the lineage of lung cancer to determine whether two separate lung cancers in the same patient are independent tumors or a tumor that has spread to another region of the lung, a Mayo Clinic study has found. For patients with multiple tumors, that distinction could mean the difference between early stage cancer that may be cured by surgery and incurable late-stage disease.

12 Nov 2014

Genomic News and Research

Study: Long-term endurance training alters epigenetic pattern in the human skeletal muscle

Researchers test new nanopore DNA sequencing technology to detect cause of antibiotic resistance

Case Western Reserve selected to lead $27.3 million international effort to identify causes of SUDEP

Most parents interested in newborn genomic testing, study reveals

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

Scientists uphold mouse model of human disease, but pinpoint vital differences in gene expression

Researchers publish first comprehensive characterization of genetic diversity in Sub-Saharan Africa

University of Chicago collaborates with NCI to set up Genomic Data Commons

Maternal age and successful egg freezing with PGS: an interview with Dr. Santiago Munné

Researchers explore how to turn on the activity of paternal gene

CCR5 receptor plays key role in driving prostate cancer metastases

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Researchers uncover easily detectable, 'pre-malignant' state in the blood

Genom Austria project to explore impact of genome sequencing on science and society

Researchers discover two common genetic variants associated with memory performance

Researchers examine genomic landscapes of humans and mice

Researchers explore new ways to treat, prevent Streptococcus pneumoniae

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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