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New definitions can specify high-risk comorbidity combinations for older surgical patients

A new way to identify more specific, higher-risk groups of older surgical patients can help in clinical decision-making and accurately comparing the performance of one hospital to another, according to research published in the Journal of the American College of Surgeons.

16 Mar 2023

Diagnosis and treatment of food allergies using a molecular approach

Researchers discuss molecular methods for food allergy assessments, including diagnostic and prognostic markers, as well as existing therapies.

15 Mar 2023

The relationship between intestinal microbiome dysbiosis and atherosclerosis

Researchers investigate the impact of intestinal microbiota dysbiosis on atherosclerotic cardiovascular disease incidence.

15 Mar 2023

How does soy consumption affect the risk of type 2 diabetes and cardiovascular diseases?

A higher intake of plant protein could effectively improve metabolic health and lower CVD mortality. Recently, scientists in China reviewed existing literature and conducted a meta-analysis to understand the association between increased soy consumption and the risk of T2D and CVDs. This review is available in the journal Nutrients.

15 Mar 2023

Four COVID-19 booster doses most effective way to prevent critical Omicron BA.5

A study published in JAMA Network Open explores the protective efficacy of previous exposure to omicron subvariants and booster vaccination against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) omicron BA.5 infection.

15 Mar 2023

Malfunctioning of novel regulatory brain mechanism may be an early contributor of Alzheimer's disease

Researchers from Drexel University have uncovered a novel regulatory mechanism in the brain that is essential for making the right kinds of proteins that promote healthy brain function, and its malfunctioning may be an early contributor of the development of Alzheimer's disease.

15 Mar 2023

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. In this study, the authors identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and explored hub gene-mediated immune infiltration in atherosclerosis.

15 Mar 2023

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Patients with cystic fibrosis (CF) face difficulty breathing and a decline in lung function and are at risk of early death. CF is an inherited condition that results in thick mucus build-up, persistent infection and inflammation in the lungs.

15 Mar 2023

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly.

15 Mar 2023

Research uncovers a possible explanation for sex differences in pancreatic cancer

Immunotherapy is an effective form of therapy for different types of cancer. However, for pancreatic cancer, its effect is limited and differs between men and women.

15 Mar 2023

‘Glow-in-the-dark’ proteins could make disease diagnosis quicker and easier

Despite recent advancements, many highly sensitive diagnostic tests for viral diseases still require complicated techniques to prepare a sample or interpret a result, making them impractical for point-of-care settings or areas with few resources.

15 Mar 2023

Researchers design a virus-resistant, more useful E. coli bacteria

In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

15 Mar 2023

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Houston Methodist scientists reversed infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein, showing further evidence that links high cholesterol to female infertility.

15 Mar 2023

An emerging target for chronic kidney disease treatment - DNA-PKcs

A recent Nature Communications study suggested that DNA-PKcs could be a potential target for treating chronic kidney disease.

15 Mar 2023

A convergent coexpression approach identifies novel genes associated with autism

The current study analyzes transcriptional convergence across many autism risk genes.

14 Mar 2023

How does dietary intervention affect aging?

Aging is a process that includes multiple interwoven mechanisms that interact with lifestyle factors. A new review seeks to encapsulate the available information on the effect of diet on aging at the cellular level in humans.

14 Mar 2023

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs) - specialized molecules that can modulate RNA and alter protein production - directly injected into the cerebrospinal fluid, in the space around the brain and spinal cord.

14 Mar 2023

XBP1s plays a key role in controlling IL-15-mediated NK cell survival, study shows

A new study published in Science Immunology points to a promising therapeutic approach for future cancer treatments based on natural killer cells (NK), which are immune cells that bind to tumor cells and destroy them.

14 Mar 2023

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma - the deadliest type of primary brain cancer - and other solid tumors.

14 Mar 2023

Protein C News and Research

New definitions can specify high-risk comorbidity combinations for older surgical patients

Diagnosis and treatment of food allergies using a molecular approach

The relationship between intestinal microbiome dysbiosis and atherosclerosis

How does soy consumption affect the risk of type 2 diabetes and cardiovascular diseases?

Four COVID-19 booster doses most effective way to prevent critical Omicron BA.5

Malfunctioning of novel regulatory brain mechanism may be an early contributor of Alzheimer's disease

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

Research uncovers a possible explanation for sex differences in pancreatic cancer

‘Glow-in-the-dark’ proteins could make disease diagnosis quicker and easier

Researchers design a virus-resistant, more useful E. coli bacteria

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

An emerging target for chronic kidney disease treatment - DNA-PKcs

A convergent coexpression approach identifies novel genes associated with autism

How does dietary intervention affect aging?

New genetic animal model may inform potential therapeutic options for Down syndrome

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

XBP1s plays a key role in controlling IL-15-mediated NK cell survival, study shows

Correcting abnormalities in solid tumor's blood vessels can improve efficacy of CAR-T cell therapy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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