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Northwestern scientists continue to advance the understanding of COVID-19

As the COVID-19 pandemic enters its third year, Northwestern Medicine scientists continue to help advance the understanding of the disease and its impact, from investigating antibody protection against COVID-19 reinfection to elevating women in academic research and highlighting racial and ethnic disparities in COVID-19 hospital mortality in Illinois.

28 Mar 2022

Study evaluates receptor-binding domain antibodies for their ability to bind and neutralize Omicron

Researchers evaluated the ability of RBD antibodies to bind to and neutralize SARS-CoV-2 Omicron variant.

28 Mar 2022

Tuberculosis infection protects mice against COVID-19

To study if prior Mtb infection affects the response to CoV2 infection, K18-hACE2 (ACE2) and C57BL/6 (B6) mice were infected with Mtb, and post thirty days, were exposed to CoV2.

27 Mar 2022

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

A new study has focussed on screening and identification of possible SMIs of this PPI for COVID-19.

25 Mar 2022

Study explores macrophage susceptibility to SARS-CoV-2 virions

A new study investigated the susceptibility of macrophages to SARS-CoV-2 virions.

25 Mar 2022

Topologically designed antibody candidates for SARS-CoV-2 and cancer therapies

A recent study presented topologically engineered fragment crystallizable-fusion proteins and antibodies as therapeutic options for diseases like human coronaviruses infections and cancers.

25 Mar 2022

Study evaluates the clinical accuracy of two FDA-approved rapid antigen tests across SARS-CoV-2 variants

Researchers evaluated clinical accuracy and analytical detection capabilities of the two US Food and Drug Administration-approved rapid antigen tests across SARS-CoV-2 variants.

25 Mar 2022

Model for investigating the effect of mutations on the binding affinity of the SARS-CoV-2 RBD-ACE2 complex

Researchers used a CNN regression model to investigate the effect of mutations on the binding affinity of the SARS-CoV-2 RBD-ACE2 complex.

25 Mar 2022

A novel mRNA vaccine encoding delta RBD induces high neutralizing antibody titers

A team of international scientists has developed an mRNA-based coronavirus disease 2019 (COVID-19) vaccine encoding the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant. The vaccine candidate has shown high efficacy in inducing neutralizing antibodies and protecting against delta infection in mice. The study is currently available on the bioRxiv* preprint server.

24 Mar 2022

Breast milk components show potent in vitro SARS-CoV-2 inhibition

Human breastmilk contains substances that can inhibit infection by SARS-CoV-2 and its variants, as well as prevent its replication.

24 Mar 2022

U of A researcher receives $436,642 from NIH to study effects of SARS-COV-2 on the aortic valve

The National Institute of Health awarded $436,642 to associate professor of biomedical engineering, Kartik Balachandran, to study the downstream effects of acute respiratory syndrome coronavirus 2 on the aortic valve.

24 Mar 2022

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Researchers evaluated the stability and expression of mutations in the spike protein of SARS-CoV-2.

24 Mar 2022

$Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties$

ACE2 News and Research

Northwestern scientists continue to advance the understanding of COVID-19

Study evaluates receptor-binding domain antibodies for their ability to bind and neutralize Omicron

Tuberculosis infection protects mice against COVID-19

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

Study explores macrophage susceptibility to SARS-CoV-2 virions

Topologically designed antibody candidates for SARS-CoV-2 and cancer therapies

Study evaluates the clinical accuracy of two FDA-approved rapid antigen tests across SARS-CoV-2 variants

Model for investigating the effect of mutations on the binding affinity of the SARS-CoV-2 RBD-ACE2 complex

A novel mRNA vaccine encoding delta RBD induces high neutralizing antibody titers

Breast milk components show potent in vitro SARS-CoV-2 inhibition

U of A researcher receives $436,642 from NIH to study effects of SARS-COV-2 on the aortic valve

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties

Uptake of SARS-CoV-2 spike protein in human cerebrovascular cells

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Study discovers potent and selective human monoclonal antibodies against Omicron variant of SARS-CoV-2

Umbrella analysis of the effect of renin-angiotensin-aldosterone system inhibitors on COVID-19 related outcomes

Novel monoclonal antibody found to have substantial neutralizing capacity against SARS-CoV-2 Omicron variant

Importance of Numb-associated kinases in SARS-CoV-2 infection

Study reveals differences in SARS-CoV-2 and SARS-CoV-1 spike protein conformational changes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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