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Study of human embryonic stems cells identifies bottlenecks restricting formation of colonies

A time-lapse study of human embryonic stems cells has identified bottlenecks restricting the formation of colonies, a discovery that could lead to improvement in their use in regenerative medicine.

13 Jun 2014

INTEGRA's VIAFLO 96 handheld multichannel pipette improves efficiency of genetic screening

The Institute of Genetics and Development of Rennes, France reports on how, using a VIAFLO 96 handheld multichannel pipette from INTEGRA, they have been able to improve the efficiency and speed with which they replicate yeast strain collections and perform genetic screens in 96 well plates.

From INTEGRA Biosciences 5 Jun 2014

NCCN receives $2M grant to evaluate effectiveness of volasertib in treatment of hematologic malignancies

The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) has been awarded a $2-million grant from Boehringer Ingelheim Pharmaceuticals, Inc.

23 May 2014

Phase I study reveals abemaciclib drug shows evidence of single-agent activity in NSCLC patients

Abemaciclib, an oral drug administered twice daily, currently in development by Eli Lilly and Company (NYSE: LLY), has shown evidence of single-agent activity in patients with advanced non-small cell lung cancer in a Phase I study released ahead of the American Society of Clinical Oncology (ASCO) Annual Meeting to be held in Chicago, Ill.

15 May 2014

Nimotuzumab enhances chemo-radiosensitivity by promoting autophagic cell death in ESCC cells

A study which will be published in the May 2014 issue of Experimental Biology and Medicine was aimed at determining whether an EGFR-targeted therapy combined with chemo-radiotherapy can improve local tumor control effectively, compared to cytotoxic agents or irradiation alone.

14 May 2014

Phasefocus invited to present a two day workshop on label-free cell imaging at CATIM

Phase Focus Ltd (Phasefocus), the company that is revolutionising microscopy and imaging with the Phasefocus Virtual Lens®, has been invited to present a two day workshop on label-free cell imaging at CATIM – the Centre for Alternative Testing and In-vitro Monitoring on Tuesday 24th and Wednesday 25th June. The meeting will take place at the Frenchay Campus of the University of the West of England, Bristol.

From Phase Focus Limited 6 May 2014

Virginia researchers develop new combination therapy that could potentially treat multiple myeloma

Each year, more than 25,000 Americans are diagnosed with multiple myeloma, a form of blood cancer that often develops resistance to therapies.

2 May 2014

Two internationally known scholars join Huntsman Cancer Institute

Two internationally known scholars, one in the field of cancer prevention and the other in the field of molecular biology, will join Huntsman Cancer Institute (HCI) at the University of Utah as early as Sept. 1.

29 Apr 2014

Researcher to recieve 2014 EMBO Gold Medal at FEBS-EMBO Meeting

EMBO today announced Sophie Martin of the University of Lausanne, Switzerland, as the winner of the 2014 EMBO Gold Medal. The award acknowledges her work to understand the molecular events that define the organization and development of the cell.

25 Apr 2014

Oxygen-rich postnatal atmosphere results in cell cycle arrest of cardiomyocytes

Scientific research at UT Southwestern Medical Center previously discovered that the newborn animal heart can heal itself completely, whereas the adult heart lacks this ability. New research by the same team today has revealed why the heart loses its incredible regenerative capability in adulthood, and the answer is quite simple - oxygen.

25 Apr 2014

Highly advanced imaging method helps to monitor rapid changes in glutathione redox potentials in live cells

In the April issue of Experimental Biology and Medicine a multidisciplinary research team led by Drs. Rex Gaskins and Paul Kenis in the Institute of Genomic Biology (IGB) on the campus of the University of Illinois Urbana-Champaign describe their recent work on subcellular redox homeostasis.

21 Apr 2014

B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process.

18 Apr 2014

Boehringer grants volasertib 'orphan drug designation' for treatment of patients with AML

Boehringer Ingelheim announced today that the US Food and Drug Administration (FDA) and the European Commission have granted volasertib* 'orphan drug designation' for the treatment of patients with acute myeloid leukaemia (AML).

17 Apr 2014

Rice University research targets Parkinson's, Huntington's and other proteasomal diseases

Synthetic genetic circuitry created by researchers at Rice University is helping them see, for the first time, how to regulate cell mechanisms that degrade the misfolded proteins implicated in Parkinson's, Huntington's and other diseases.

9 Apr 2014

Nanostring Technologies launches nCounter PanCancer Pathways Panel

NanoString Technologies, Inc., (NASDAQ:NSTG) a provider of life science tools for translational research and molecular diagnostic products, today announced the launch of the nCounter® PanCancer Pathways Panel, a highly-multiplexed, digital gene expression assay that offers a unique way for translational researchers to investigate cancer biology across all major cancer pathways.

From NanoString Technologies 8 Apr 2014

Eli Lilly presents early-stage data from several targeted cancer therapies at AACR 2014

Eli Lilly and Company will present early-stage data from several targeted cancer therapies – including bemaciclib "beh meh sye' klib" (LY2835219), its oral, cell-cycle inhibitor of CDK4/6 – that make up its diverse clinical oncology pipeline during the American Association for Cancer Research (AACR) Annual Meeting 2014 held in San Diego, Calif. from April 5 – 9.

7 Apr 2014

Stowers team reports genome-wide analysis of genes that drive cell division in multicellular organism

In textbooks, the grand-finale of cell division is the tug-of-war fought inside dividing cells as duplicated pairs of chromosomes get dragged in opposite directions into daughter cells.

3 Apr 2014

IRB researchers identify dual role of p38 protein in colon cancer

A team headed by Angel R. Nebreda at the Institute for Research in Biomedicine identifies a dual role of the p38 protein in colon cancer. The study demonstrates that, on the one hand, p38 is important for the optimal maintenance of the epithelial barrier that protects the intestine against toxic agents, thus contributing to decreased tumour development.

28 Mar 2014

Protein known to promote cancer appears to give blood vessels strength and shape, researchers report

A protein known to promote cancer appears to give the blood vessels strength and shape, researchers report. When yes-associated protein, or YAP, is deleted from vascular smooth muscle cells during development, the protein makes thin-walled blood vessels that over-dilate in response to the usual pressure of blood flow, said Dr. Jiliang Zhou, vascular biologist at the Medical College of Georgia at Georgia Regents University.

25 Mar 2014

Researcher discover new chemical class that attacks two key cancer cell building block targets

Imagine cutting down the growth of cancer cells at their earliest stages to halt tumor growth. Research conducted by leading cancer metabolism researchers at Stony Brook University, Paul M. Bingham, PhD, and Zuzana Zachar, PhD, is showing promise in this approach with their clinical investigation of a new class of compounds that disrupt cancer cell mitochondrial metabolism.

14 Mar 2014